Publications by authors named "Li-Ping Ning"
Article Synopsis
- Type II complex is linked to both invasive and non-invasive infections in humans, with 11 strains identified from samples collected in China using advanced laboratory techniques.
- Whole genome sequencing was performed to analyze genotypes, revealing high minimum inhibitory concentrations (MICs) to amphotericin B and one isolate showing extreme resistance to 5-flucytosine.
- These findings suggest that the strains primarily pose a risk to patients with weakened immune systems, and the resistance to key antifungal treatments could complicate clinical management.
First two fungemia cases caused by in China with emerged antifungal resistance.
Front Microbiol
November 2022
Article Synopsis
- A rare fungal variant has been linked to human infections, necessitating accurate identification through DNA sequencing techniques, specifically targeting the rDNA internal transcribed spacer (ITS) region.
- This study involved collecting two strains from a Chinese hospital to compare the identification capabilities of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and VITEK 2 YST ID biochemical methods against conventional ITS sequencing.
- Results showed that both strains were misidentified at the species level by the MS methods and exhibited significant drug resistance, highlighting the emergence of drug-resistant fungal species in China that pose a risk for invasive diseases.
Objective: To explore the function and mechanism of microRNA-155 to regulate the angiogenesis after the cerebral infarction of rats through the angiotensin II receptor 1 (AT1R)/vascular endothelial growth factor (VEGF) signaling pathway.
Methods: Female SD rats were chosen for the construction of cerebral infarction model of rats using the modified right middle cerebral artery occlusion. The real-time PCR (RT-PCR) method was employed to detect the expression of microRNA-155 in each group at different time points after the cerebral infarction (1 h, l d, 3 d and 7 d).
The role of actin filaments in allodynia induced by chronic compression of the dorsal root ganglion (DRG) (CCD) and the effects of microfilaments dynamics on transient receptor potential vanilloid 4 (TRPV4) were investigated in this study. Anti-microfilaments agents resulted in dose-dependent and partial reduction in CCD-induced allodynia, which could be prevented by the prior stabilizer administration. In association with the reduction of allodynia by microfilaments' disruption, TRPV4-mediated currents were inhibited by disruptors.
View Article and Find Full Text PDFThe aim of this study was to test the hypothesis that nuclear factor-kappa B (NF-κB) is involved in TRPV4-NO pathway in thermal hyperalgesia following chronic compression of the dorsal root ganglion (DRG) (the procedure hereafter termed CCD) in rat. Intrathecal administration of two NF-κB inhibitors, pyrrolidine dithiocarbamate (PDTC; 10(-1) to 10(-2)M) and BAY (100-50 μM), both induced significantly dose-dependent increase in the paw withdrawal latency (PWL) and decrease in nitric oxide (NO) content in DRG when compared with control rats. Pretreatment with 4α-phorbol 12,13-didecanoate (4α-PDD, transient receptor potential vanilloid 4 (TRPV4) synthetic activator, 1 nm) attenuated the suppressive effects of PDTC (10(-1)M) and BAY (100 μM) on CCD-induced thermal hyperalgesia and NO production.
View Article and Find Full Text PDFThe aim of the present study was to test the hypothesis that the TRPV4-NO-cGMP-PKG cascade is involved in the maintenance of thermal hyperalgesia following chronic compression of the dorsal root ganglion (DRG) (the procedure hereafter termed CCD) in rats. CCD rats showed thermal hyperalgesia and increased nitrite production. Intrathecal administration of ruthenium red (TRPV4 antagonist, 0.
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