Publications by authors named "Li-Ou Huang"
Article Synopsis
- Mitochondria play a key role in septic shock and inflammatory responses, prompting the need to study immune-mitochondrial genes in this condition. !* -
- The study analyzed a dataset to identify 44 mitochondrial-related genes (MitoDEGs) related to septic shock, utilizing various bioinformatics techniques and machine learning to validate four diagnostic genes: PGS1, C6orf136, THEM4, and EPHX2. !* -
- Results indicated that these MitoDEGs have significant diagnostic potential and are associated with immune cell infiltration, particularly with neutrophils being the most abundant in septic shock cases. !*
Background: Antimicrobial de-escalation refers to starting the antimicrobial treatment with broad-spectrum antibiotics, followed by narrowing the drug spectrum according to culture results. The present study evaluated the effect of de-escalation on ventilator-associated pneumonia (VAP) in trauma patients.
Methods: This retrospective study was conducted on trauma patients with VAP, who received de-escalation therapy (de-escalation group) or non-de-escalation therapy (non-de-escalation group).