Publications by authors named "Li-Na Chen"

The mere token strategy, which adds a small reward (token) to an option to increase attractiveness, is widely used in the consumer field. However, we conducted six studies that seek to confirm the 'token undermining effect', where adding a small token to a sooner and smaller reward (SS) paired with a later and larger reward (LL) decreases the preference for the SS. The results showed that the effect persists across various choice sets, participant populations, reward amounts, delays, outcome properties and regardless of whether the scenarios are incentivized.

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  • * The increasing prevalence of MRMP, particularly noted in East Asia since 2000, results in extended hospitalization, poor treatment responses, and higher use of glucocorticoids and alternative antibiotics.
  • * A group of 29 experts from China developed the first global consensus on diagnosing and treating pediatric MRMP pneumonia, emphasizing the importance of early identification and appropriate treatment strategies based on current evidence.
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Numerous studies have highlighted the emergence of coronavirus disease (COVID-19) symptoms reminiscent of Kawasaki disease in children, including fever, heightened multisystem inflammation, and multiorgan involvement, posing a life-threatening complication. Consequently, extensive research endeavors in pediatric have aimed to elucidate the intricate relationship between COVID-19 infection and the immune system. COVID-19 profoundly impacts immune cells, culminating in a cytokine storm that particularly inflicts damage on the pulmonary system.

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The microenvironment and cell populations within the myometrium play crucial roles in maintaining uterine structural integrity and protecting the fetus during pregnancy. However, the specific changes occurring at the single-cell level in the human myometrium between nonpregnant (NP) and term pregnant (TP) states remain unexplored. In this study, we used single-cell RNA sequencing (scRNA-Seq) and spatial transcriptomics (ST) to construct a transcriptomic atlas of individual cells in the myometrium of NP and TP women.

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Malaria, one of the major global public health events, is a leading cause of mortality and morbidity among children and adults in tropical and subtropical regions(mainly in sub-Saharan Africa), threatening human health. It is well known that malaria can cause various complications including anemia, blackwater fever, cerebral malaria, and kidney damage. Conventionally, cardiac involvement has not been listed as a common reason affecting morbidity and mortality of malaria, which may be related to ignored cases or insufficient diagnosis.

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Imidazolinones were obtained in good yields by intramolecular hydroamination of -alkoxy ureas in the presence of an organic photocatalyst and an inorganic base. In this reaction, the -alkoxy urea anion generated by deprotonation undergoes photocatalyzed single-electron-transfer oxidation to generate the corresponding radical, which cyclizes to afford the imidazolinone ring. This new protocol grants access to an array of complex molecules containing a privileged imidazolinone core.

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The purpose of this study is to explore the associations among dry eye disease (DED), air pollution, and meteorological conditions in the cold region of a northeastern Chinese metropolis (i.e., Changchun).

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Background: Cyclin-dependent kinase inhibitor 1C () is a cell proliferation inhibitor that regulates the cell cycle and cell growth through G1 cell cycle arrest. mutations can lead to IMAGe syndrome ( allele gain-of-function mutations lead to intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenital, and genitourinary malformations). We present a Silver-Russell syndrome (SRS) pedigree that was due to a missense mutation affecting the same amino acid position, 279, in the gene, resulting in the amino acid substitution p.

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Background: Norovirus is a leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution of the norovirus ORF2. These characteristics were found in hospital-based symptomatic infections, whereas, asymptomatic infections are frequent and contribute significantly to transmission.

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As a classic prescription, Wuji Pills is composed of Coptidis Rhizoma, Euodiae Fructus Preparata, and stir-fried Paeo-niae Radix Alba at the ratio of 6∶1∶6. The practical application of it is limited compared with other famous Chinese medicine prescriptions. Only one company produces Wuji Pills in China.

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Introduction: Heat shock protein 40 (HSP40) is a vaccine adjuvant candidate for Streptococcus pneumoniae. The mechanism by which HSP40 activates the human dendritic cells (DCs) is unclear.

Methods: DCs were isolated from human peripheral blood and their markers (HLA-DR, CD86, CD83, and CD80) were detected by flow cytometry.

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Background: Brain tumors are the most common solid tumors in children and comprise 25% of all malignancies in children. Common presentations include headache, nausea and vomiting, gait abnormality, papilledema, and epileptic seizure; however, some symptoms can be very insidious, with atypical and misleading manifestations.

Case Summary: Here, we report a 7-year-old boy who presented with recurrent cyanosis and tachypnea after exercise for 2 years.

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To report 2 successfully managed cases of graft rejection with acellular porcine corneal stroma (APCS) transplantation in patients with fungal corneal ulcer. Two patients were diagnosed with fungal corneal ulcer and received APCS transplantation. Graft rejection developed due to the lost follow-up during the period of coronavirus disease 2019 outbreak.

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SOX11 is a transcription factor belonging to the sex determining region Y-related high-mobility group box family that plays a vital role in early embryogenesis and neurogenesis. variants in have been initially reported to cause a rare neurodevelopmental disorder, mainly referred to Coffin-siris syndrome 9 (CSS9, OMIM# 615866) which is characterized with growth deficiency, intellectual disability (ID), microcephaly, coarse facies, and hypoplastic nails of the fifth fingers and/or toes. A recent large-scale cohort study suggests that variation would result in a clinically and molecularly distinct disease from CSS.

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Herbivore-induced defense responses are often specific, whereas plants could induce distinct defense responses corresponding to infestation by different herbivorous insects. Brown plant hopper (BPH) , a phloem-feeding insect, and rice leaf folder (LF) , a chewing insect, are both specialist herbivores on rice. To characterize the distinct resistance primed by prior damage to these two specialist herbivores, we challenged rice plants with two herbivores during vegetative growth of parent plants and assessed plant resistance in subsequent ratoons.

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Background: Pulmonary lymphomatoid granulomatosis (PLG) is a lymphoproliferative disease associated with Epstein-Barr viral infection occurring mainly in adults and rarely in children. It is characterized by multiple pulmonary nodules. Its diagnosis depends on lung biopsy findings.

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Article Synopsis
  • * The G8 strains identified were DS-1-like and derived from human sources, indicating they did not directly transmit from animals but likely arose from genetic reassortment.
  • * Whole genome sequencing of these strains was conducted, revealing significant genetic variation, and further research is needed to determine their clinical and epidemiological impacts.
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CO poisoning of Pt-group metal catalysts is a long-standing problem, particularly for hydrogen oxidation reaction in proton exchange membrane fuel cells. Here, we report a catalyst of Ru oxide-coated Ru supported on TiO (Ru@RuO/TiO), which can tolerate 1-3% CO, enhanced by about 2 orders of magnitude over the classic PtRu/C catalyst, for hydrogen electrooxidation in a rotating disk electrode test. This catalyst can work stably in 1% CO/H for 50 h.

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An efficient N-centered radical intramolecular cyclization reaction of alkenyl amides induced by visible light was described. In this process, an alkenyl amide underwent / cyclization to selectively yield two critical alkaloid structures, namely isoindolinones and isoquinolinones.

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  • Noroviruses are RNA viruses that cause acute gastroenteritis and have many diverse genotypes, complicating vaccine development.
  • A study analyzed NoV sequences from an extended period, identifying genotypes that could evade immunity, and selected key strains for potential vaccine candidates.
  • The research highlighted 16 distinct GII.4 variants showing a clear evolutionary pattern, with specific variants identified as prime targets for future NoV vaccines.
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The present study examined how resveratrol affects cell growth and MAGEA12/Akt signaling pathway in OSCC cells. Cal-27 cells were transiently transfected with a plasmid encoding , and the effects of overexpression were assessed in terms of cell viability, colony formation and the epithelial-mesenchymal transition. Cal-27 cells and -overexpressing cells were treated with resveratrol, then the cell viability and colony formation were also assessed by CCK8 assay and microscope, respectively.

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Corona virus disease 2019(COVID-19) has brought untold human sufferings and economic tragedy worldwide. It causes acute myocardial injury and chronic damage of cardiovascular system, which has attracted much attention from researchers. For the immediate strategy for COVID-19, "drug repurposing" is a new opportunity for developing drugs to fight COVID-19.

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PARK7 mutations are accountable for the inherited Parkinson's disease. An induced pluripotent stem cell (iPSC) line FJMUUHi001-A was generated by expressing five reprogramming factors, OCT3/4, SOX2, c-MYC, KLF4 and BCL-XL, in peripheral blood mononuclear cells from a 32-year old patient carrying a homozygous mutation of c.189dupA in PARK7.

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  • Rotaviruses are the main cause of severe diarrhea in kids, and certain genetic factors in humans, known as histo-blood group antigens (HBGAs), may influence how these viruses attach and cause infections.
  • A study conducted in rural Hebei province, China, analyzed saliva and serum from children to understand the relationship between HBGA secretor status and RV infection risk.
  • The findings revealed that a higher percentage of children with RV infections were HBGA secretors compared to non-infected controls, suggesting potential genetic susceptibility and highlighting the need for a universal rotavirus vaccination program in China.
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