Publications by authors named "Li-Mei Wen"
Article Synopsis
- This study investigates the effects of Panax notoginseng saponins (PNS) on diabetic kidney disease (DKD) using network pharmacology, molecular docking, and animal experiments.
- Key targets identified for PNS include AKT1, STAT3, and others, with relevant pathways related to cancer and signaling highlighted in the analysis.
- Animal trials showed that PNS significantly lowered blood glucose levels and improved kidney damage in diabetic mice, indicating its potential therapeutic effect on DKD.
Article Synopsis
- - Nonalcoholic fatty liver disease (NAFLD), particularly nonalcoholic steatohepatitis (NASH), is a common chronic liver condition, and the Yanxiao Di'naer formula (YXDNE) from Uyghur traditional medicine has been used historically to treat liver issues, though its effectiveness and mechanisms in NASH remain poorly defined.
- - This study aimed to evaluate the effectiveness of YXDNE for treating NASH using a high-fat, high-cholesterol diet and carbon tetrachloride in mice, alongside detailed analysis of its components and mechanisms involving various metabolic pathways.
- - Results indicated that YXDNE significantly improved NASH in mice by influencing fatty acid metabolism and activating key signaling
Ethnopharmacological Relevance: Ischemic stroke (IS) has both high morbidity and mortality. Previous research conducted by our group demonstrated that the bioactive ingredients of the traditional medicinal and edible plant Cistanche tubulosa (Schenk) Wight (CT) have various pharmacological effects in treating nervous system diseases. However, the effect of CT on the blood-brain barrier (BBB) after IS are still unknown.
View Article and Find Full Text PDFBackground: Recent evidence has shown that prophylactic antibiotic treatment in patients with acute pancreatitis is not associated with a significant decrease in mortality or morbidity. The use and efficacy of prophylactic antibiotic treatment in acute pancreatitis remain controversial. This meta-analysis was conducted to assess whether antibiotic prophylaxis is beneficial in patients with acute pancreatitis.
View Article and Find Full Text PDFThe use of combination drugs is considered to be a promising strategy to control complex diseases such as ischemic stroke. The detection of metabolites has been used as a versatile tool to reveal the potential mechanism of diverse diseases. In this study, the levels of 12 endogenous AAs were simultaneously determined quantitatively in the MCAO rat brain using RRLC-QQQ method.
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