Publications by authors named "Li-Ling Xu"
Lymphography is a useful technique in the diagnosis of lymphatic diseases. Conventional lymph node imaging methods, such as subcutaneous and footpad injections, are invasive and unable to visualize mesenteric lymph nodes. Liposomes have the potential to increase the oral bioavailability of poorly bioavailable hydrophilic drugs and promote their lymphatic transport in the intestinal lymph.
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- The study examines how effective machine learning, particularly the Random Forest Classifier, is in predicting thyroid-specific autoantibodies in patients with Primary Sjogren's syndrome (pSS) based on clinical data.
- A total of 96 pSS patients were analyzed through thyroid function tests to categorize them by the presence of autoantibodies, leading to the exploration of various risk factors using four different machine learning algorithms.
- The Random Forest Classifier yielded the best results (AUC = 0.755), highlighting age, IgG levels, complement C4, and dry mouth as significant predictors for autoimmune thyroiditis in these patients.
Article Synopsis
- - Dyspnea-related kinesiophobia is a common issue among older adults with chronic obstructive pulmonary disease (COPD), causing them to avoid activities due to the fear of shortness of breath, highlighting the need to identify subgroups affected by this phenomenon.
- - The study aimed to explore the different levels of kinesiophobia among older adults with COPD through a questionnaire survey, analyzing factors like sociodemographics and health status that may influence these subgroups.
- - Results revealed two distinct groups of kinesiophobia: a low-level group (59.9%) and a high-level group (40.1%). Key findings indicated that those in the high-level group were less active, had lower income, and often faced various
Background Purpose: Rituximab (RTX),an anti-CD20 monoclonal antibody can effectively treat minimal change disease (MCD),with low toxicity and a reduced steroid dosage. The optimal dosage of RTX for treating MCD remains unclear. This study aimed to investigate the efficacy of an ultra-low-dose regimen of RTX (100 mg per week for 4 weeks) for treating MCD.
View Article and Find Full Text PDFPurpose: Children with acute leukemia have suffered from a considerable symptom burden during chemotherapy. However, few studies have focused on exploring the mechanisms among symptoms in children with acute leukemia. Our study aims to explore core symptoms and describe the interrelationships among symptoms in children with acute leukemia during chemotherapy.
View Article and Find Full Text PDFBackground: Previous studies have examined symptom clusters in children with acute leukemia, yet a knowledge gap persists regarding central symptom clusters and their influencing factors. By identifying these central clusters and associated factors, healthcare providers can enhance their understanding and effective management of symptoms. Our study seeks to address this gap by identifying symptom clusters, exploring central clusters, and investigating the demographic and health-related factors associated with these clusters in children with acute leukemia undergoing chemotherapy.
View Article and Find Full Text PDFDried blood spot (DBS) based PCR was considered an inexpensive and feasible method for detecting pathogens in the blood. The DBS carrier filter paper and PCR kits are crucial for accurate diagnosis. We evaluated 4 types of filter papers and 20 PCR kits for DBS samples.
View Article and Find Full Text PDFThe aim of this study was to describe radiography, computed tomography (CT), and magnetic resonance imaging (MRI) findings of enzootic nasal tumors in goats infected with enzootic nasal tumor viruses. Five of six goats with a mean age of 2 years, showed clinical signs of respiratory disease. Head radiographs showed increased density of the unilateral or bilateral nasal cavity in four goats, and a CT scan showed that the space-occupying lesion of the nasal cavity originated from the ethmoid bone and was enhanced homogeneously postcontrast in all goats.
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- Intrauterine hypoxia (IUH) negatively affects the growth and cognitive development of offspring, with varying impacts based on sex; female rats showed motor and cognitive deficits at 2 months, while male rats experienced more severe effects at 4 months.
- The study assessed the cognitive and motor functions of IUH-affected rats, revealing that IUH did not alter specific protein levels in the brain but increased Tau5 protein in females at 2 months.
- Spermidine (SPD) treatment helped prevent weight loss and reversed cognitive declines in IUH-affected female offspring, suggesting that SPD could mitigate some of the cognitive impairments caused by IUH.
Organic pesticides are one of the main environmental pollutants, and how to reduce their environmental risks is an important issue. In this contribution, we disclose the molecular basis for the resistance of American sloughgrass to aryloxyphenoxypropionic acid pesticides using site-directed mutagenesis and molecular modeling and then construct an effective screening model. The results indicated that the target-site mutation (Trp-1999-Leu) in acetyl-coenzyme A carboxylase (ACCase) can affect the effectiveness of the pesticides (clodinafop, fenoxaprop, cyhalofop, and metamifop), and the plant resistance to fenoxaprop, clodinafop, cyhalofop, and metamifop was found to be 564, 19.
View Article and Find Full Text PDFAdvanced live cell imaging studies suggested that B cell activation is initiated by the formation of BCR microclusters and subsequent B cell IS upon BCR and antigen recognition. PKC family member PKC is highly expressed in B cells and plays an important role in the initiation of B cell activation. Here, we reported an inhibitory function of PKC through a negative-feedback manner in B cell activation.
View Article and Find Full Text PDF[Quality of life of patients with arthritis in China].
Zhonghua Liu Xing Bing Xue Za Zhi
December 2003
Objective: To evaluate the quality of life of arthritis patients in China.
Methods: Patients (n = 1 344) were selected by stratified random sampling according to the economic conditions and the ranking of hospitals, and asked to complete the arthritic self-reported questionnaire of quality of life.
Results: The scores of quality of life were not different between male arthritis and female arthritis in different age groups (P > 0.