Development and application of a nomogram model for predicting the risk of central precocious puberty in obese girls.

Objective: The purpose of this study is to develop and assess a nomogram risk prediction model for central precocious puberty (CPP) in obese girls.

Methods: We selected 154 cases of obese girls and 765 cases of non-obese girls with precocious puberty (PP) who underwent the gonadotropin-releasing hormone stimulation test at the Jiangxi Provincial Children's Hospital. Univariate analysis and multivariate analysis were conducted to identify predictors of progression to CPP in girls with PP.

A Clinical Study of Girls With Idiopathic Central Precocious Puberty and Psychological Behavior Problems.

To understand the psychological effects on behavior of girls with idiopathic central precocious puberty (ICPP) and to explore the role of gonadotropin-releasing hormone analog (GnRHa) in the reversal or blocking of the negative psychological effects on behaviors of girls with ICPP. A total of 100 girls with ICPP diagnosed at the Department of Endocrinology of Jiangxi Children's Hospital were divided into the treatment group and observation group with 50 cases in each group. The control group consisted of 50 healthy girls examined at our hospital during the same period.

Characteristics and karyotype analysis of a patient with turner syndrome complicated with multiple-site tumors: A case report.

Turner syndrome (TS) is a congenital chromosomal abnormality that affects approximately 1 in 2,500 people. Both in China and abroad, few studies exist on the incidence of tumors in patients with TS. Most reported cases are complicated with gonadal germ cell tumors, and extragonadal tumors are rare, with the latter not yet being reported in China.

Effectiveness of Mobile Medical Apps in Ensuring Medication Safety Among Patients With Chronic Diseases: Systematic Review and Meta-analysis.

Background: Along with the rapid growth of the global aging society, the mobile and health digital market has expanded greatly. Countless mobile medical apps (mmApps) have sprung up in the internet market, aiming to help patients with chronic diseases achieve medication safety.

Objective: Based on the medication safety action plans proposed by the World Health Organization, we aimed to explore the effectiveness of mmApps in ensuring the medication safety of patients with chronic diseases, including whether mmApps can improve the willingness to report adverse drug events (ADEs), improve patients' medication adherence, and reduce medication errors.

Present situation and analysis of factors affecting perimenopausal syndrome among clinical nurses-a cross-sectional survey.

Background: The quality of life of women is seriously affected by perimenopausal symptoms and related diseases. Clinical nurses often suffer from job burnout due to high pressure and intensity of work and life, which is easy to induce and aggravate perimenopausal syndrome. Nursing occupational environment varies greatly in different economic regions, but relevant studies are limited to northern cities, and are often confined to the second and third grade hospitals or a hospital in a certain region, lacking multi-center studies on hospitals of different grades.

Novel mutation of type-1 insulin-like growth factor receptor (IGF-1R) gene in a severe short stature pedigree identified by targeted next-generation sequencing.

Insulin-like growth factor receptor (IGF-1R) deficiency is a rare form of short stature, and is difficult to clinically diagnose. Targeted next-generation sequencing (NGS) allows for the rapid and inexpensive assessment of short stature. We identified mutations in the pedigree of a Chinese boy with severe short stature using targeted NGS; we then assessed the clinical characteristicsand evaluated the efficacy of growth hormone therapy.

Construction of Nursing Quality Control Information System in Large Hospitals.

Based on the process and framework of nursing quality management in the "Third-level General Ho Accreditation Criteria", with the help of computer and mobile information technology, development of nursing quality control informatics system computer operation and mobile operating. The system has implanted PDCA several scientific management tools into the mobile applications, insteads of replace traditional paper methods, improve working efficiency in process control and Data Operation.

Structural elucidation of galactomannan from seeds of Crotalaria mucronata Desv. by atomic force microscopy.

A non-ionic water-soluble galactomannan, isolated from the seed endosperm of Crotalaria mucronata Desv., may be an ideal thickener to increase food viscosity. The present study hypothesized that the viscous property of Crotalaria galactomannan may be associated with its spatial structure.

Body mass index is inversely associated with arterial stiffness in Chinese adults with primary hypertension: results from the China Stroke Primary Prevention Trial (CSPPT).

Background: This study aimed to elucidate the relationship between body mass index (BMI) and the presence of arterial stiffness in rural-dwelling Chinese adults with primary hypertension.

Methods: Primary hypertension patients (n = 19,375) receiving an average of 4.5 years of antihypertension therapy were selected from the Chinese Stroke Primary Prevention Trial (mean age: 64.

[Association between single nucleotide polymorphism of insulin-like growth factor receptor gene and idiopathic short stature].

Objective: To study the association between single nucleotide polymorphism (SNP) of insulin-like growth factor I receptor (IGF-IR) gene and idiopathic short stature (ISS).

Methods: A total of 804 children with ISS and 575 normal controls were recruited from 2008 to 2011. IGF-IR gene SNP was genotyped using the Snapshot Multiplex System.

[Study on extraction and purification process of total ginsenosides from Radix Ginseng].

Objective: To optimize the technological parameters of the extraction and purification process of total ginsenosides from Radix Ginseng.

Methods: With the contents of ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1, the orthogonal design was adopted to optimize the extraction process. The purification process was studied by optimizing the elutive ratio of total ginsenosides as the marker.

Retention time reproducibility in comprehensive two-dimensional gas chromatography using cryogenic modulation an intralaboratory study.

A survey was conducted to determine the reproducibility of retention times in both the first (D1) and second dimension (D2) axes of the two-dimensional separation space, in the comprehensive two-dimensional gas chromatographic analysis of an essential oil sample using cryogenic modulation. The retention times in the two dimensions for a number of individual components comprising hydrocarbon, alcohol, ester and ketone chemical classes in a Melaleuca alternifolia essential oil were recorded from replicate analyses using four separate column sets and two identical gas chromatographs. Run-to-run, day-to-day, instrument-to-instrument, and column set-to-column set reproducibility were demonstrated from the experimental design.