Virtual Position Guided Strategy for Particle Swarm Optimization Algorithms on Multimodal Problems.

Premature convergence is a thorny problem for particle swarm optimization (PSO) algorithms, especially on multimodal problems, where maintaining swarm diversity is crucial. However, most enhancement strategies for PSO, including the existing diversity-guided strategies, have not fully addressed this issue. This paper proposes the virtual position guided (VPG) strategy for PSO algorithms.

Inhibitory Effect of PPARδ Agonist GW501516 on Proliferation of Hypoxia-induced Pulmonary Arterial Smooth Muscle Cells by Regulating the mTOR Pathway.

Objective: This study aimed to investigate the effects of the peroxisome proliferator-activated receptor δ (PPARδ) agonist GW501516 on the proliferation of pulmonary artery smooth muscle cells (PASMCs) induced by hypoxia, in order to search for new drugs for the treatment and prevention of pulmonary vascular remodeling.

Methods: PASMCs were incubated with different concentrations of GW501516 (10, 30, 100 nmol/L) under the hypoxic condition. The proliferation was determined by a CCK-8 assay.

[Expression Changes of Hypoxia-Inducible Factor-1α in G-CSF Induced Hematopoietic Stem Cell Mobilization].

Objective: To investigate the expression and its relative mechanism of hypoxia-inducible factor-1α(HIF-1α) in bone marrow(BM) of mice during G-CSF mobilization of hematopoietic stem cells (HSC) .

Methods: Flow cytometry was used to detect the proportion of LinSca-1 c-kit (LSK) cells in peripheral blood of C57BL/6J mice before and after G-CSF mobilization. And the expression of HIF-1α and osteocalcin (OCN) mRNA and protein were detected by RQ-PCR and immunohistochemistry.

[Pollution Characteristics and Health Risk Assessment of Heavy Metals in PM of Different Air Masses During Heating Season in Tianjin].

In order to explore the pollution characteristics and health risks of heavy metals in PM in Tianjin, heavy metal samples (Pb, Cd, Cr, As, Zn, Mn, Co, Ni, Cu, and V) in PM were analyzed from November 2020 to March 2021 using the Xact-625 heavy metal online analyzer. The spatial and temporal distribution characteristics were analyzed using the HYSPLIT model, and the health risks of heavy metals were analyzed using the US EPA risk assessment model. The results indicated that the average total concentration of the 10 heavy metal elements was (261.

Five-year remission without disease progression in a patient with relapsed/refractory multiple myeloma with extramedullary disease treated with LCAR-B38M chimeric antigen receptor T cells in the LEGEND-2 study: a case report.

Background: Multiple myeloma remains incurable despite treatment advancements over the last 20 years. LCAR-B38M Cells in Treating Relapsed/Refractory Multiple Myeloma was a phase 1, first-in-human, investigator-initiated study in relapsed/refractory multiple myeloma conducted at four sites in China. The study used LCAR-B38M chimeric antigen receptor-T cells expressing two B-cell maturation antigen-targeting single-domain antibodies designed to confer avidity, and a CD3ζ signaling domain with a 4-1BB costimulatory domain to optimize T-cell activation and proliferation.

The J-Protein AtDjC5 Facilitates Thermotolerance Likely by Aiding in the ER Stress Response.

AtDjC5 belongs to the J-protein family in . Its biological functions remain unclear. In this study, we examined the roles of AtDjC5 in resisting heat stress using reverse genetic analysis.

Neural network-based event-triggered data-driven control of disturbed nonlinear systems with quantized input.

This paper is devoted to design an event-triggered data-driven control for a class of disturbed nonlinear systems with quantized input. A uniform quantizer reconstructed with decreasing quantization intervals is employed to reduce the quantization error. A neural network-based estimation strategy is proposed to estimate both the pseudo partial derivative and disturbances.

Cavernous hemangioma of the ileum in a young man: A case report and review of literature.

Background: Small intestinal cavernous hemangioma is a rare disease, especially in the ileum. It is difficult to accurately diagnose due to its hidden location and nonspecific clinical symptoms. Here, we reported a case of ileal cavernous hemangioma with chronic hemorrhage in a 20-year-old man and review the literature to gain a better understanding of this disease.

Laparoscopic versus Conventional Open Surgery Approach of Tunica Vaginalis for Palpable Cryptorchidism.

Objective: To evaluate the advantages of the laparoscopic approach of tunica vaginalis in the treatment of palpable cryptorchidism.

Study Design: Randomised clinical comparative study.

Place And Duration Of Study: Department of Urology Surgery, Baoding Children's Hospital, Baoding, Hebei, China, from July 2019 to June 2020.

Microplastics contamination in groundwater of a drinking-water source area, northern China.

Although the contamination of microplastics (MPs) in groundwater has been anticipated, their occurrence, distribution, and composition require further understanding. In this study, the occurrence and distributions of MPs were investigated in shallow groundwater from an important water source district in Tianjin city of northern China. The abundance, the physical morphology, the chemical composition, and the potential correlations of the determined MPs with human activities were thoroughly characterized.

cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity.

Porcine reproductive and respiratory syndrome virus (PRRSV) is an RNA virus that causes great economic losses globally to the swine industry. Innate immune RNA receptors mainly sense it during infection. As a DNA sensor, cyclic GMP-AMP synthase (cGAS) plays an important role in sensing cytosolic DNA and activating innate immunity to induce IFN-I and establish an antiviral cellular state.

Characteristics of Retained Foreign Bodies in the Tongue: A Retrospective Study of 35 Cases.

Purpose: There are only a few case reports of foreign bodies (FBs) in the tongue. Delayed diagnosis or misdiagnosis is commonly reported. The purpose of this study was to identify the demographic, clinical, and radiological features that might facilitate the diagnosis of retained FBs in the tongue.

Reduced Plasma Estradiol Levels are Associated with Sleep Apnea in Depressed Peri- and Post-Menopausal Women.

Objective: This study aimed at investigating the correlation between estradiol and sleep apnea among women with major depressive disorders during the perimenopausal and postmenopausal periods.

Methods: A total of 84 perimenopausal and postmenopausal women diagnosed with depression, and who had been subjected to whole-night polysomnography (PSG) were retrospectively studied. They were assigned into two groups based on the presence of OSA (apnea-hypopnea index (AHI)≥5) (OSA vs non-OSA).

A Qualitative Exploration of the Psychological Experience of Patients Hospitalized With COVID-19.

This qualitative study describes the psychological experience of patients hospitalized with COVID-19. These patients went through 3 psychological stages: extremely uncertainties during the initial diagnostic stage, complicated feelings of negativity during the treatment stage, and positive growth in the recovery stage. It is important for nurses to provide holistic care.

Influence on denitrifying community performance by the long-term exposure to sulfamethoxazole and chlortetracycline in the continuous-flow EGSB reactors.

The response of the denitrification community to long-term antibiotic exposure requires further investigation. Here, the significantly altered denitrifying community structure and function were observed by continuous exposure to 1 mg/L sulfamethoxazole (SMZ) or chlortetracycline (CTC) for 180 d in the expanded granular sludge bed reactors. Thaurea, positively correlated with SMZ and NO removal efficiency (NrE), was highly enriched in the SMZ-added reactor, while, Comamons and Acinetobacter were largely inhibited.

[Extinction Characteristics of Aerosols and the Contribution of Pollution Sources to Light Extinction During Three Heavy Pollution Episodes in the Winter of 2020 in Tianjin].

This study examined high-resolution online monitoring data from January to February 2020 to study the extinction characteristics and sources of heavy pollution episodes during winter in Tianjin. Heavy pollution episodes occurred during this period from January 16 to 18 (episode Ⅰ), from January 24 to 26 (episode Ⅱ), and from February 9 to 10 (episode Ⅲ). The results showed that the concentrations of PM during the three heavy pollution episodes were (229±52), (219±48), and (161±25) μg·m, respectively, with NO, SO, NH, OC, EC, Cl, and K comprising the main species.

An Effective Swarm Intelligence Optimization Algorithm for Flexible Ligand Docking.

In general, flexible ligand docking is used for docking simulations under the premise that the position of the binding site is already known, and meanwhile it can also be used without prior knowledge of the binding site. However, most of the optimization search algorithms used in popular docking software are far from being ideal in the first case, and they can hardly be directly utilized for the latter case due to the relatively large search area. In order to design an algorithm that can flexibly adapt to different sizes of the search area, we propose an effective swarm intelligence optimization algorithm in this paper, called diversity-controlled Lamarckian quantum particle swarm optimization (DCL-QPSO).

[Characteristics and Sources of VOCs at Different Ozone Concentration Levels in Tianjin].

To further study the effect of volatile organic compounds (VOCs) on ozone pollution, the characteristics and sources of VOCs at different ozone (O) concentration levels were analyzed, using high-resolution online monitoring data obtained from Tianjin in the summer of 2019. Results showed that VOCs concentrations were 32.94, 38.

[Formation and Prevention of Secondary Nitrate in PM in Tianjin].

To study the formation and approaches to controlling secondary nitrate in PM, the ionic compositions of PM, pH of aerosols, variations in NH-NH and HNO-NO concentrations, and the joint NH/HNO sensitivity regime map of ammonium nitrate were investigated based on high-resolution online monitoring data for an urban site in central Tianjin from 2018 to 2019. The results showed that the average concentration of PM was 58μg·m, and the main ionic compositions of PM were nitrate (NO), ammonium (NH), sulfate (SO), Cl, and K with corresponding mass percentages of 18.4%, 11.

[Size Distribution of Aerosol Hygroscopic Growth Factors in Winter in Tianjin].

Aerosol hygroscopic growth factors[(RH)] are key for evaluating aerosol light extinction and direct radiative forcing. The hygroscopic tandem differential mobility analyzer (HTDMA) was utilized to measure the size-resolved (RH) under different polluted conditions in winter in Tianjin. Furthermore, based on the size distribution of aerosol water-soluble ions, the (RH) across a wide size range (60 nm to 9.

[Characterization and Source Apportionment of Atmospheric VOCs in Tianjin in 2019].

The characterization and source apportionment of atmospheric volatile organic compounds (VOCs) in Tianjin in 2019 were investigated based on high-resolution online monitoring data observed at an urban site in Tianjin. The results showed that the average annual concentration of VOCs was 48.9 μg·m, and seasonal concentrations followed with winter (66.

[Characterization and Source Apportionment of PM Based on the Online Observation in Tianjin].

To study the characterization and source apportionment of PM in Tianjin, based on high-resolution online monitoring data from 2017 to 2019, the concentrations and its chemical compositions and sources of PM were analyzed. The results showed that the average concentration of PM was 61 μg ·m. The primary chemical compositions of PM were nitrate, organic carbon (OC), ammonium, sulfate, elemental carbon (EC), and Cl and their corresponding mass percentages to PM were 17.

[Characteristics of Secondary Organic Particles and the Potential Formation of SOA from VOCs During Wintertime Heavy Pollution Episodes in Tianjin].

The characteristics of secondary organic reactions were studied based on supersite monitoring data from January to March, 2019, in Tianjin. During heavy pollution episodes, SOC (secondary organic carbon) accounted for between 3.1% and 3.