Publications by authors named "Li-Lan Liu"
Objective: Phthalates (PEs) could cause reproductive harm to males. A mixture of three widely used PEs (MPEs) was used to investigate the ameliorative effects of zinc (Zn) and vitamin E (VE) against male reproductive toxicity.
Methods: Fifty male SD rats were randomly divided into five groups (n = 10).
Phthalates (PEs), such as di(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and butyl benzyl phthalate (BBP) could cause reproductive and developmental toxicities, while human beings are increasingly exposed to them at low-doses. Phytochemical quercetin (Que) is a flavonoid that has estrogenic effect, anti-inflammatory and anti-oxidant effects. This study was conducted to assess the alleviative effect of Que.
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- Phthalates are chemicals used in plastic that can harm male reproductive health, and this study looked at how a plant chemical called quercetin might help protect against that harm.
- Male rats were tested to see how these chemicals affected their bodies over 91 days, and results showed that the rats exposed to phthalates had issues like lower weight of reproductive organs and badly damaged cells.
- The addition of quercetin helped restore the rats' hormone levels and improve their reproductive health, suggesting that it may help counteract the negative effects of phthalates.
Protective effect of quercetin against phthalates induced hepatotoxicity in rats.
Toxicol Res (Camb)
October 2022
Article Synopsis
- This study examines how commonly used phthalates (like BBP, DBP, and DEHP), which are plasticizers, can lead to liver damage in rats, especially by inducing oxidative stress.
- Male Sprague-Dawley rats were given a 30-day treatment with a mix of these phthalates, showing significant liver damage as indicated by various biochemical markers and liver tissue analysis.
- However, the introduction of quercetin, a phytochemical, at different doses helped reduce the liver damage and oxidative stress caused by phthalates, likely by neutralizing free radicals and restoring important liver protective pathways.
Background: Phthalates (PEs), such as butyl benzyl phthalate, dibutyl phthalate and di(2-ethylhexyl) phthalate, are one of the most widely used plasticizers, and humans are increasingly exposed to them. Phytochemical quercetin (Que) is a typical flavonoid with several biological effects, such as antioxidative and anti-inflammatory. The present study was designed to explore the effect of Que on testicular toxicity caused by the mixture of three commonly used PEs (MPEs), and the underlying mechanism.
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