Publications by authors named "Li-Kun Gao"
Article Synopsis
- This study aimed to highlight the effectiveness of contrast-enhanced computed tomography (CECT) in distinguishing between bladder paraganglioma (BPG) and bladder cancer.
- Researchers analyzed medical records from 19 patients with BPG and 56 patients with bladder cancer, focusing on imaging results from both unenhanced and contrast-enhanced CT scans.
- Key findings revealed significant differences in patient age, tumor characteristics, and specific CT values, indicating that certain CECT measurements can effectively help differentiate between BPG and bladder cancer, particularly in the corticomedullary phase.
Metastasis is the most common cause of death in ovarian cancer patients but remains largely untreated. Epithelial‑mesenchymal transition (EMT) is critical for the conversion of early‑stage ovarian tumors into metastatic malignancies. Thus, investigating the signaling pathways promoting EMT may identify potential targets for the treatment of metastatic ovarian cancer.
View Article and Find Full Text PDFInvasive micropapillary carcinoma (IMPC) is a rare type of malignant tumor of breast with a poor prognosis. There is controversy in the identification of mucinous variant of IMPC with mucinous carcinoma. In the past, it always be diagnosed as micropapillary variant of mucinous carcinoma, but in this study, the author has a different opinion.
View Article and Find Full Text PDFThis work was aimed at fabricating and characterizing poly(vinyl alcohol) films that were reinforced by nanofibrillated corn husk celluloses using a combination of chemical pretreatments and ultrasonication. The obtained nanofibrillated celluloses (NFCs) possessed a narrow width ranging from 50 to 250 nm and a high aspect ratio (394). The crystalline type of NFC was cellulose I type.
View Article and Find Full Text PDFDexmedetomidine alleviates pulmonary edema by upregulating AQP1 and AQP5 expression in rats with acute lung injury induced by lipopolysaccharide.
J Huazhong Univ Sci Technolog Med Sci
October 2015
This study aims to elucidate the mechanisms by which dexmedetomidine alleviates pulmonary edema in rats with acute lung injury induced by lipopolysaccharide (LPS). Male Wistar rats were randomly divided into five groups: normal saline control (NS) group, receiving intravenous 0.9% normal saline (5 mL/kg); LPS group, receiving intravenous LPS (10 mg/kg); small-dose dexmedetomidine (S) group, treated with a small dose of dexmedetomidine (0.
View Article and Find Full Text PDF[MicroRNA383 regulates expression of PRDX3 in human medulloblastomas].
Zhonghua Bing Li Xue Za Zhi
August 2012
Objective: To investigate the effects of microRNA-383 (miR-383) on PRDX3 gene expression, cell proliferation and apoptosis of human medulloblastma.
Methods: PRDX3 and miR-383 RNA expression was detected by real-time quantitative RT-PCR in human medulloblastoma tumor tissue samples, Daoy cell line and normal brain tissue samples. Western blot was used to detect protein expression of PRDX3.
Article Synopsis
- - The study aimed to investigate how an antisense oligonucleotide targeting microRNA-21 (miR-21) affects cervical cancer cells (SiHa) by testing it in both lab settings (in vitro) and in living organisms (in vivo).
- - Results showed that the antisense miR-21 led to a significant reduction in miR-21 levels, inhibiting cell growth, colony formation, and promoting cell apoptosis more effectively compared to control groups.
- - The study concluded that targeting miR-21 with antisense oligonucleotides successfully suppresses cervical cancer cell growth and increases apoptosis, indicating potential for therapeutic applications.