Tumor-Targeted Magnetic Micelles for Magnetic Resonance Imaging, Drug Delivery, and Overcoming Multidrug Resistance.

Nasopharyngeal carcinoma (NPC) is prevalent in Southern China. Unfortunately, current treatments encounter multidrug resistance (MDR). Overexpression of P-glycoprotein (P-gp), resulting in the efflux of chemotherapy drugs, is one of the significant mechanisms causing MDR.

Prediction of cervical lymph node metastasis in solitary papillary thyroid carcinoma based on ultrasound radiomics analysis.

Objective: To assess the utility of predictive models using ultrasound radiomic features to predict cervical lymph node metastasis (CLNM) in solitary papillary thyroid carcinoma (PTC) patients.

Methods: A total of 570 PTC patients were included (456 patients in the training set and 114 in the testing set). Pyradiomics was employed to extract radiomic features from preoperative ultrasound images.

Aprotic Lithium-Oxygen Batteries Based on Nonsolid Discharge Products.

Aprotic lithium-oxygen (Li-O) batteries are considered to be a promising alternative option to lithium-ion batteries for high gravimetric energy storage devices. However, the sluggish electrochemical kinetics, the passivation, and the structural damage to the cathode caused by the solid discharge products have greatly hindered the practical application of Li-O batteries. Herein, the nonsolid-state discharge products of the off-stoichiometric LiO in the electrolyte solutions are achieved by iridium (Ir) single-atom-based porous organic polymers (termed as Ir/AP-POP) as a homogeneous, soluble electrocatalyst for Li-O batteries.

Accelerated Confined Mass Transfer of MoS 1D Nanotube in Photo-Assisted Metal-Air Batteries.

Applying solar energy into energy storage battery systems is challenging in achieving green and sustainable development, however, the efficient progress of photo-assisted metal-air batteries is restricted by the rapid recombination of photogenerated electrons and holes upon the photocathode. Herein, a 1D-ordered MoS nanotube (MoS-ONT) with confined mass transfer can be used to extend the lifetime of photogenerated carriers, which is capable of overcoming the challenge of rapid recombination of electron and holes. The tubular confined space cannot only promote the orderly separation and migration of charge carriers but also realize the accumulation of charge and the rapid activation of oxygen molecules.

Intrinsic Stress-strain in Barium Titanate Piezocatalysts Enabling Lithium-Oxygen Batteries with Low Overpotential and Long Life.

Rechargeable lithium-oxygen (Li-O ) batteries with high theoretical energy density are considered as promising candidates for portable electronic devices and electric vehicles, whereas their commercial application is hindered due to poor cyclic stability caused by the sluggish kinetics and cathode passivation. Herein, the intrinsic stress originated from the growth and decomposition of the discharge product (lithium peroxide, Li O ) is employed as a microscopic pressure resource to induce the built-in electric field, further improving the reaction kinetics and interfacial Lithium ion (Li ) transport during cycling. Piezopotential caused by the intrinsic stress-strain of solid Li O is capable of providing the driving force for the separation and transport of carriers, enhancing the Li transfer, and thus improving the redox reaction kinetics of Li-O batteries.

Polymers with Intrinsic Microporosity as Solid Ion Conductors for Solid-State Lithium Batteries.

Solid-state electrolytes (SSEs) with high ionic conductivity and superior stability are considered to be a key technology for the safe operation of solid-state lithium batteries. However, current SSEs are incapable of meeting the requirements for practical solid-state lithium batteries. Here we report a general strategy for achieving high-performance SSEs by engineering polymers of intrinsic microporosity (PIMs).

Efficacy and safety of Tuina and intermediate frequency electrotherapy for frozen shoulder: MRI-based observation evidence.

Background: Tuina and Intermediate Frequency (IF) electrotherapy are commonly used treatments for frozen shoulder (FS). This study aimed to compare the clinical efficacy of Tuina and IF electrotherapy in the treatment of stage II frozen shoulder and to provide evidence-based treatment for FS.

Methods: The FS patients were randomized into two groups, the observation group, which received Tuina, and the control group, which received IF electrotherapy.

Metal-Organic Framework-Based Mixed Conductors Achieve Highly Stable Photo-assisted Solid-State Lithium-Oxygen Batteries.

The demand for high-energy sustainable rechargeable batteries has motivated the development of lithium-oxygen (Li-O) batteries. However, the inherent safety issues of liquid electrolytes and the sluggish reaction kinetics of existing cathodes remain fundamental challenges. Herein, we demonstrate a promising photo-assisted solid-state Li-O battery based on metal-organic framework-derived mixed ionic/electronic conductors, which simultaneously serve as the solid-state electrolytes (SSEs) and the cathode.

Aerobic exercise reverses the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin to alleviate post-stroke depression.

Background: Post-stroke depression (PSD) is one of the most common and serious sequelae of stroke. The pathogenesis of PSD involves both psychosocial and biological mechanisms, and aerobic exercise is a potential therapeutic target. We conducted an in-depth exploration of the protective mechanisms of aerobic exercise in a PSD mouse model.

Unraveling the Mechanism of Field-Induced Li Concentration for Improved Kinetics in Rechargeable Li-CO Batteries.

The design of highly efficient electrocatalysts is a promising strategy to improve the electrochemical kinetics of Li-CO batteries. However, electrocatalysts usually aim to reduce the energetic barrier for the corresponding electrochemical reactions; little attention has been given to modulating the kinetics that directly determine the local concentration of reaction molecules surrounding catalysts. Herein, we present a systematic study on the role of Li reunion on the improvement of reaction kinetics in Li-CO batteries with a Cu cone cathode.

All-Solid-State Photo-Assisted Li-CO Battery Working at an Ultra-Wide Operation Temperature.

At present, photoassisted Li-air batteries are considered to be an effective approach to overcome the sluggish reaction kinetics of the Li-air batteries. And, the organic liquid electrolyte is generally adopted by the current conventional photoassisted Li-air batteries. However, the superior catalytic activity of photoassisted cathode would in turn fasten the degradation of the organic liquid electrolyte, leading to limited battery cycling life.

LncRNA NEAT1 alleviates ischemic stroke via transcriptional inhibition of NLRP3 mediated by the miR‑10b‑5p/BCL6 axis.

Cerebral ischemic stroke (CIS) is a significant cause of disability and death. Inflammation usually occurs after CIS and accelerates cellular damage. NLRP3 plays a key role in the formation of CIS‑associated inflammasome.

Two new bibenzyls from (Rolfe) Rolfe and their antioxidant activity.

Two new bibenzyls ( and ) were isolated from the pseudobulbs of (Rolfe) Rolfe along with six known compounds, including isoarundinin I (), isoarundinin II (), bulbocodin D (), batatasin III (), 5,3'-dihydroxy- 4-(-hydroxybenzyl)-3-methoxybibenzyl () and shancigusin F (). Their structures were established on the basis of spectroscopic methods. These compounds showed potent DPPH free radical scavenging effects with IC values ranging from 49.

Oxygen Vacancy-Mediated Growth of Amorphous Discharge Products toward an Ultrawide Band Light-Assisted Li-O Batteries.

Photoassisted electrochemical reaction is regarded as an effective approach to reduce the overpotential of lithium-oxygen (Li-O ) batteries. However, the achievement of both broadband absorption and long term battery cycling stability are still a formidable challenge. Herein, an oxygen vacancy-mediated fast kinetics for a photoassisted Li-O system is developed with a silver/bismuth molybdate (Ag/Bi MoO ) hybrid cathode.

LncRNA NEAT1 ameliorate ischemic stroke via promoting Mfn2 expression through binding to Nova and activates Sirt3.

Background: Recent studies revealed that long non-coding RNAs (lncRNAs) have significant roles in regulating the pathogenesis of ischemia stroke, and oxygen-glucose deprivation/reoxygenation (OGD/R)-induced cell apoptosis. Aberrant expression of NEAT1 was found after the injury of ischemia-reperfusion, but the mechanism was not fully understood.

Methods: The expression of NEAT1 and Mfn2 were detected in BV-2 and N2a cell with or without OGD/R-induced by qRT-PCR.

Magnetic and Optical Field Multi-Assisted Li-O Batteries with Ultrahigh Energy Efficiency and Cycle Stability.

The photoassisted lithium-oxygen (Li-O ) system has emerged as an important direction for future development by effectively reducing the large overpotential in Li-O batteries. However, the advancement is greatly hindered by the rapidly recombined photoexcited electrons and holes upon the discharging and charging processes. Herein, a breakthrough is made in overcoming these challenges by developing a new magnetic and optical field multi-assisted Li-O battery with 3D porous NiO nanosheets on the Ni foam (NiO/FNi) as a photoelectrode.

A Renewable Light-Promoted Flexible Li-CO Battery with Ultrahigh Energy Efficiency of 97.9.

Directly converting and storing abundant solar energy in next-generation energy storage devices is of central importance to build a sustainable society. Herein, a new prototype of a light-promoted rechargeable and flexible Li-CO battery with a TiO /carbon cloth (CC) cathode is reported for the direct utilization of solar energy to promote the kinetics of the carbon dioxide reduction reaction and carbon dioxide evolution reaction (CO ER). Under illumination, photoelectrons are generated in the conduction band of TiO /CC, followed by the enhancing diffusion of electrons and lithium ions during the discharge process.

Driving Oxygen Electrochemistry in Lithium-Oxygen Battery by Local Surface Plasmon Resonance.

Although the lithium-oxygen (Li-O) battery brings hope for the improvement of high-energy rechargeable batteries, the sluggish oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) kinetics become the major stumbling block. Herein, the incorporation of a plasmonic silver cathode as an advanced strategy to promote ORR and OER kinetics due to strong local surface plasmon resonance (LSPR) is introduced. Chronoamperometry results revealed that the highly energetic electrons and holes excited by LSPR of silver nanostructure facilitated ORR and OER kinetics ascribe to the emission of hot carriers in femtosecond time scale.

Visceral and subcutaneous adipose tissue, which one induced thyroid dysfunction in patients with morbid obesity.

Background: Thyroid dysfunction in patients with morbid obesity usually resolves after bariatric surgery. However, the role of diverse types of adipose tissue in the process remains unknown.

Objectives: We aim to investigate the effects of visceral and subcutaneous fat on thyroid function in a Chinese population with morbid obesity who underwent sleeve gastrectomy (SG).

Real-world data on the use of secukinumab as treatment for moderate-to-severe psoriasis in Chinese patients.

Background: The efficacy and safety of secukinumab, an interleukin-17 inhibitor, as systemic treatment for patients with moderate-to-severe psoriasis have been demonstrated, but real-world data pertaining to this is limited in China.

Objective: To evaluate the efficacy and safety of secukinumab in clinical practice in Chinese psoriasis patients with or without psoriatic arthritis (PsA) and identify potential baseline factors that affect the response of patients to secukinumab treatment.

Materials & Methods: Data from 81 patients treated with secukinumab for at least 16 weeks were analysed in a retrospective observational study.

Light/Electricity Energy Conversion and Storage for a Hierarchical Porous In S @CNT/SS Cathode towards a Flexible Li-CO Battery.

A photoinduced flexible Li-CO battery with well-designed, hierarchical porous, and free-standing In S @CNT/SS (ICS) as a bifunctional photoelectrode to accelerate both the CO reduction and evolution reactions (CDRR and CDER) is presented. The photoinduced Li-CO battery achieved a record-high discharge voltage of 3.14 V, surpassing the thermodynamic limit of 2.

Ozone alleviates ischemia/reperfusion injury by inhibiting mitochondrion-mediated apoptosis pathway in SH-SY5Y cells.

Cerebral ischemia/reperfusion (I/R) injuries are common and often cause severe complications. Ozone has been applied for protecting I/R injury in animal models of several organs including cerebra, but the detailed mechanism remains unclear. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and lactate dehydrogenase measurement were used to determine the influence of ozone on cell activity and damage of SH-SY5Y cells.

Iatrogenic crystalline lens injury during intravitreal injection of triamcinolone acetonide: A report of two cases.

Background: Intravitreal injection has become an efficient approach for delivering drugs at therapeutic levels to the posterior segment in retinal diseases. However, the increased frequency and number of intravitreal injections have raised concerns about their side effects. As manipulation during surgery is relatively simple, details of the procedure are easily overlooked.