Effects of microRNA-29a on retinopathy of prematurity by targeting AGT in a mouse model.

Background: This study aimed to explore the effects of microRNA-29a (miR-29a) on retinopathy of prematurity (ROP) by targeting angiotensinogen (AGT) expression in a mouse model.

Methods: Ninety-six C57BL/6J mice were selected and divided into the normal control group (n = 12) and the oxygen-induced retinopathy (OIR) group (n = 84). All the mice in the OIR group were assigned to the following seven groups (12 mice in each group): the blank, miR-29a mimics, miR-29a inhibitors, empty plasmid, miR-29a mimics + si-AGT, miR-29a inhibitors + si-AGT and si-AGT groups.

Refractive status and optical components of premature babies with or without retinopathy of prematurity at 3-4 years old.

Purpose: To investigate the refractive status and optical components of premature babies with or without retinopathy of prematurity (ROP) at 3-4 years old, and to explore the influence of prematurity and ROP on the refractive status and optical components.

Methods: Premature babies receiving fundus examination were recruited into ROP group and non-ROP group, with age-matched full-term babies as controls.

Results: The incidence of myopia was the highest in ROP (3/59, 5.