Publications by authors named "Li-Juan Lei"
Article Synopsis
- - PCSK9 is a protein that binds to LDLR in the liver and causes its degradation, leading to higher cholesterol levels; targeting PCSK9 can help manage cholesterol levels and reduce conditions like hypercholesterolemia and atherosclerosis.
- - A new compound called E28362 was identified as a potential PCSK9 inhibitor through virtual screening, showing promise in increasing LDLR levels and reducing LDL cholesterol in lab tests and animal models.
- - In studies with hamsters and mice on high-fat diets, E28362 effectively lowered cholesterol and triglyceride levels and decreased atherosclerotic lesions, indicating its potential as a treatment for cholesterol-related diseases.
In this paper, we present the discovery of a novel salicylic acid derivative, moldavica acid A (), and a new natural dibenzo[b,f]oxepin, moldavica acid B (), together with four known phenylpropionic acids (-) and protocatechuic acid () that were isolated from L. Their structures were elucidated by comprehensive spectroscopic methods, including infrared and nuclear magnetic resonance. Compound is the first example of salicylic acid linking a carboxylated -pyrone via an ethyl bridge.
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