SUMOylation of TP53INP1 is involved in miR-30a-5p-regulated heart senescence.

Heart senescence is critical for cardiac function. This study aimed to characterize the role and mechanism of action of miR-30a-5p in cardiac senescence. miR-30a-5p was downregulated in aged mouse hearts and neonatal rat cardiomyocytes (NRCMs).

Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis.

Context: Concanavalin A (Con A) exhibited multiple roles in cancer cells. However, the role of Con A in endothelial cells was not reported.

Objective: Our present study investigated the potential angiogenic role of Con A in endothelial cells and ischaemic hind-limb mice.

Ubiquitinated ligation protein NEDD4L participates in MiR-30a-5p attenuated atherosclerosis by regulating macrophage polarization and lipid metabolism.

MiR-30a-5p plays an important role in various cardiovascular diseases, but its effect in atherosclerosis has not been reported. Apolipoprotein E-deficient (Apo E) mice were used to investigate the role of miR-30a-5p in atherosclerosis, and the underlying mechanism was investigated and . The fluorescence hybridization test revealed that miR-30a-5p was expressed in Apo E mice lesions.

Regional scalable priorities for national biodiversity and carbon conservation planning in Asia.

To achieve the goals of the post-2020 global biodiversity framework, we must identify representative targets that effectively protect biodiversity and can be implemented at a national level. We developed a framework to identify synergies between biodiversity and carbon across the Asian region and proposed a stepwise approach based on scalable priorities at regional, biome, and national levels that can complement potential Convention on Biological Diversity targets of protecting 30% land in the post-2020 global biodiversity framework. Our targets show that 30% of Asian land could effectively protect over 70% of all assessed species relative to only 11% now (based on analysis of 8932 terrestrial vertebrates), in addition to 2.

Pretreatment of cardiac progenitor cells with bradykinin attenuates HO-induced cell apoptosis and improves cardiac function in rats by regulating autophagy.

Background: Previous studies have demonstrated that human cardiac c-Kit progenitor cells (hCPCs) can effectively improve ischemic heart disease. However, the major challenge in applying hCPCs to clinical therapy is the low survival rate of graft hCPCs in the host heart, which limited the benefit of transplanted hCPCs. Bradykinin (BK) is a principal active agent of the tissue kinin-kallikrein system.

The association between adiponectin gene rs182052 polymorphism and cancer risk: a meta-analysis.

Background: The evidence for an association between the adiponectin gene (ADIPOQ) polymorphism rs182052 and cancer risk is inconsistent. We performed a meta-analysis to obtain more precise conclusions.

Methods: The PubMed, Embase, and Web of Science databases were searched until July 11, 2019.

The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis.

Background: The rs2057482 polymorphism in the hypoxia inducible factor 1 subunit alpha (HIF1A) gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitively confirmed. We performed this meta-analysis to determine whether rs2057482 is associated with overall cancer risk.

Methods: The PubMed, Embase, and Web of Science databases were searched for the potential studies about the association between the rs2057482 and cancer risk.

Circulating miRNA-302 family members as potential biomarkers for the diagnosis of acute heart failure.

Aim: To explore circulating miRNA-302 family members for acute heart failure (AHF) diagnosis.

Methods: Three groups of subjects, in other words, AHF patients, AHF free patients and healthy controls were recruited. Circulating levels of miR-302 family members were measured and analyzed for AHF diagnosis.

Tape-Based Photodetector: Transfer Process and Persistent Photoconductivity.

We report a facile transfer method to fabricate flexible photodetectors directly on tape, wherein the films formed by different processes were integrated together. The tape-based photodetectors with CdS nanowire (NW) active layers exhibited good performances as those fabricated by conventional processes. The obvious persistent photocurrent in our device was eliminated by introducing a conductive polymer poly(3,4-ethylenedioxythiophene)polystyrene sulfonate (PEDOT:PSS) onto the CdS NW layer.

Monodisperse Mesoporous Carbon Nanoparticles from Polymer/Silica Self-Aggregates and Their Electrocatalytic Activities.

In our quest to make various chemical processes sustainable, the development of facile synthetic routes and inexpensive catalysts can play a central role. Herein we report the synthesis of monodisperse, polyaniline (PANI)-derived mesoporous carbon nanoparticles (PAMCs) that can serve as efficient metal-free electrocatalysts for the hydrogen peroxide reduction reaction (HPRR) as well as the oxygen reduction reaction (ORR) in fuel cells. The materials are synthesized by polymerization of aniline with the aid of (NH4)2S2O8 as oxidant and colloidal silica nanoparticles as templates, then carbonization of the resulting PANI/silica composite material at different high temperatures, and finally removal of the silica templates from the carbonized products.

A high surface area flower-like Ni-Fe layered double hydroxide for electrocatalytic water oxidation reaction.

Layered double hydroxide has been used in a variety of areas, including but not limited to catalysis, energy storage, drug or gene delivery, water treatment, etc. Herein, we report a new simple hydrothermal method to prepare a high surface area flower-like Ni-Fe layered double hydroxide (LDH) assembled by nanosheets by using nickel alkoxide and FeSO4 as the only starting materials. It is free of alkaline solution and other additives for directing or supporting in the synthesis procedure.

Reduced TiO2 rutile nanorods with well-defined facets and their visible-light photocatalytic activity.

Stable reduced TiO2 rutile nanorods with well-defined facets were prepared by a solvothermal route in the presence of Zn powder. The oxygen vacancy in the TiO2 nanorods, which can be tuned by the amount of Zn, results in a narrow band gap and visible-light photocatalytic activity.

Nanoporous Sr-rich strontium titanate: a stable and superior photocatalyst for H2 evolution.

A synthetic route to prepare nanoporous Sr-rich strontium titanate (Sr : Ti ≈ 1.03) with a high surface area is reported. The as-obtained porous nanomaterial serves as a stable and superior photocatalyst for H2 evolution.

Precursor-mediated synthesis and sensing properties of wurtzite ZnO microspheres composed of radially aligned porous nanorods.

Wurtzite ZnO microspheres composed of radially aligned porous nanorods are prepared via a simple thermal treatment of a "pre-synthesized" zinc monoglycerolate precursor. The as-prepared hierarchical nanomaterial can serve as a highly sensitive sensing material for ethanol detection.

Facile hydrothermal preparation of graphene oxide nanoribbons from graphene oxide.

Graphene oxide nanoribbons (GONR) with regular edges have been prepared by a facile hydrothermal method. The relatively high yield and convenient preparation of GONR eventually make graphene nanoribbons (GNR) accessible in the field of composite materials where bulk quantities of nanoribbons are required.

Synthesis and photocatalytic activity of porous anatase TiO(2) microspheres composed of {010}-faceted nanobelts.

Porous anatase TiO(2) microspheres composed of {010}-faceted nanobelts were synthesized through simple thermal treatment of a titanium glycerolate precursor. The as-prepared TiO(2) nanomaterial was shown to serve as an efficient photocatalyst for H(2) evolution, and its activity was more than twice that of the benchmark P25 TiO(2).

A precursor route to single-crystalline WO3 nanoplates with an uneven surface and enhanced sensing properties.

A W-containing inorganic-organic nanohybrid with a plate-like morphology has been successfully prepared through a nonaqueous synthetic route using WCl(6) as the tungsten source and benzyl alcohol as the solvent. The as-prepared hybrid nanomaterial was used directly as an efficient precursor for the formation of WO(3) nanoplates via a simple thermal treatment process. The as-obtained WO(3) material maintains the plate-like morphology of the precursor and possesses a unique uneven surface structure.

Light-driven transformation of ZnS-cyclohexylamine nanocomposite into zinc hydroxysulfate: a photochemical route to inorganic nanosheets.

ZnS-CHA (CHA = cyclohexylamine) nanocomposite, a unique inorganic-organic hybrid semiconductor, has been prepared from a mild solvothermal reaction system. This material contains 2 nm-sized ZnS nanoparticles, and is photoactive toward UV light (≤300 nm). Under UV-irradiation, the ZnS-CHA nanocomposite is transformed to crystalline zinc hydroxysulfate nanosheets.

[Immediate implantation of an abutment tooth attached by a magnet in an overdenture: report of one case].

A female patient, aged 59 years old, underwent immediate implantation of the abutment tooth attached by a magnet in an overdenture. The tooth recovered to normal three months later. A denture was remade and the tooth was still attached by a magnet at the same time.

[Micro-tensile bond strength to sclerotic dentin in non-carious cervical lesions].

Objective: This in vitro study was to evaluate the micro-tensile bond strength (microTBS) of three adhesives to sclerotic dentin in non-carious cervical lesions.

Methods: The maxillary premolars extracted due to periodontitis and with non-carious cervical lesions were collected. The non-carious, natural cervical sclerotic lesions were bonded with a total-etching adhesive Scotchbond Multi-Purpose, a two-step self-etching adhesive Contax, and an all-in-one self-etching adhesive Adper Prompt L-Pop.

[Effect of acid etching time on bonding interface of non-carious cervical sclerotic dentin].

Objective: To examine the effect of acid etching time on the bonding interface of non-carious cervical sclerotic dentin.

Methods: Twenty extracted premolars with non-carious cervical lesions were randomly divided into two groups, the lesion surface was conditioned with Scotchbond Multi-Purpose Plus dentin bonding system. The etching time was 15 s and 30 s respectively.

[Ultrastructural study of a self-etching adhesive to sclerotic dentin in non-carious cervical lesions].

Objective: To examine, in vitro study, the ultrastructure of resin-infiltrated sclerotic dentine following the application of a two-step self-etching dentin adhesive.

Methods: Non-carious, natural cervical sclerotic lesions were bonded using Contax (DMG Hamburg, Germany), a self-etching dentin adhesive. Artificially prepared wedge-shaped lesions were also made in sound bicuspids and bonded using the same adhesive as controls.

[Ultrastructural study of sclerotic dentin in non-carious cervical lesions disposed by a total-etching dentin adhesive].

Objective: To examine the ultrastructure of resin-infiltrated sclerotic dentine following the application of a three-step total-etching dentin adhesive.

Methods: Naturally-occurring, non-carious cervical lesions on extracted premolars were bonded using a total-etching dentin adhesive-Scotchbond Multi-purpose. Artificially prepared wedge-shaped lesions were also made in sound premolars and restored using the same adhesive as control.