Early expression of tumor necrosis factor α and nuclear factor kappa B after Descemet stripping endothelial keratoplasty in rabbits.

Purpose: To investigate immune rejection after Descemet stripping endothelial keratoplasty (DSEK) compared with that after penetrating keratoplasty (PKP) in New Zealand rabbit eyes and to identify the relationship between tumor necrosis factor alpha (TNF-α) and nuclear factor kappa B (NFκB) and evaluate their involvement in graft rejection.

Methods: Sixty-nine New Zealand rabbits were divided into 3 groups: group A comprised the control group, which did not undergo either of the procedures; group B underwent DSEK; and group C underwent PKP. Twenty-three Chinese rabbits (46 eyes) were used as donors.

[Experimental research of small-incision Descemet's stripping endothelial keratoplasty].

Objective: To investigate the surgical procedure, clinical efficacy, complications, density of endothelial cells and histological changes after Descemet's stripping endothelial keratoplasty (DSEK) surgery.

Methods: It was a experimental study. Twenty four New Zealand rabbits were divided into 3 groups, 8 rabbits per group.