The study investigates the impact of total coumarins from Urtica dentata on colitis induced by dextran sulfate sodium in mice.
Mice treated with total coumarins experienced less weight loss, lower levels of inflammation markers IL-6 and IFN-gamma, and increased anti-inflammatory cytokines IL-10 and TGF-beta1.
The findings suggest that total coumarins have an anti-inflammatory effect, improving colitis symptoms by modulating inflammatory protein expressions and cytokine levels.