Chondrocyte autophagy mechanism and therapeutic prospects in osteoarthritis.

Osteoarthritis (OA) is the most common type of arthritis characterized by progressive cartilage degradation, with its pathogenesis closely related to chondrocyte autophagy. Chondrocytes are the only cells in articular cartilage, and the function of chondrocytes plays a vital role in maintaining articular cartilage homeostasis. Autophagy, an intracellular degradation system that regulates energy metabolism in cells, plays an incredibly important role in OA.

K63 Ubiquitination of P21 Can Facilitate Pellino-1 in the Context of Chronic Obstructive Pulmonary Disease and Lung Cellular Senescence.

Chronic obstructive pulmonary diseases (COPD) is a kind of age-related, airflow-obstruction disease mostly caused by cigarette smoke. However, the relationship between COPD and lung cellular senescence is still not fully understood. Here, we found silencing Pellino-1 could inhibit the protein level of P21.

[Anterior cervical discectomy and fusion in the treatment of Hangman's fracture].

Objective: To evaluate the efficacies and features of treating Hangman's fracture by anterior cervical discectomy and fusion (ACDF).

Methods: Since June 2005 to December 2008, 36 cases with Hangman's fracture were analyzed with their clinical data including history, symptoms, signs, radiological findings and treatments. According to the classification system designed by Levine and Edwards depending on the radiological manifestations of Hangman's fractures, they were subdivided into type I (n = 9) (conservative therapy), type II (n = 17) and type IIA (n = 10).

[Correlations of extrocellular matrix metalloproteinase inducer and microvessel density to invasiveness of ameloblastoma].

Background & Objective: Matrix metalloproteinases (MMPs) are involved in local invasion of ameloblastomas. This study was to evaluate the role of matrix metalloproteinase inducer (EMMPRIN) in angiogenesis in ameloblastomas by analyzing EMMPRIN expression and microvessel density (MVD) in ameloblastomas and odontogenic cysts.

Methods: EMMPRIN expression and MVD in 41 specimens of ameloblastoma and 40 specimens of odontogenic cyst were examined by SP immuno-histochemistry.

[Clinical observation on effects of acupuncture at Dazhui (GV 14) for abating fever of common cold].

Objective: To explore the therapeutic effect of acupuncture at Dazhui (GV 14) for abating fever of common cold.

Methods: Two hundred and sixty-one cases were randomly assigned to a treatment group of 133 cases and a control group of 128 cases. The treatment group were treated with electroacupuncture at Dazhui (GV 14) and the control group with antondine injection.

Cellular toxic effects of combination of low dose of cisplatin and interstitial injection of 32P glass microspheres on mouse solid tumor S180.

Background: Although 32P-glass microspheres (32P-GMS) have been used in internal radiotherapy for malignant tumors, it has been one of the key obstacles to improve the effect of radiotherapy. We investigated the cellular and hypersensitive effect of combined use of low dose of cisplatin and interstitial injection of 32P-GMS on mouse solid tumor S180.

Methods: The mice with solid tumor S180 were randomly divided into four groups (controls, cisplatin therapy, 32P-GMS therapy and combination therapy).