Publications by authors named "Li-Huan Huang"
Pedigree-based study to identify GOLGB1 as a risk gene for bipolar disorder.
Transl Psychiatry
September 2022
Article Synopsis
- Bipolar disorder (BD) shows strong genetic links, and finding new risk genes can help understand how the disease develops.
- A study analyzed a Chinese family with BD, identifying a significant mutation in the GOLGB1 gene, linked to other cases of BD.
- Experiments on neonatal mice showed that a lack of GOLGB1 affects behavior, leading to varied symptoms resembling both manic and depressive states found in BD patients, and impacts key brain signaling pathways.