Publications by authors named "Li-Hsuan Li"
Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization.
Hsin-Huei Chang Lung-Chun Lee Tsu Hsu Yi-Hui Peng Chih-Hsiang Huang Li-Mei Lin Li-Hsuan Li Ling Chang
J Med Chem
December 2024
Article Synopsis
Article Synopsis
- * The study focused on CD44-ICD, a molecule linked to inflammatory responses, to determine its impact on liver inflammation during sepsis induced by lipopolysaccharide (LPS) in mice.
- * Inhibiting CD44-ICD before LPS exposure led to reduced liver damage and inflammation, suggesting that CD44-ICD is critical in regulating liver inflammation during sepsis.
Colorectal cancer (CRC) is the fourth leading cause of cancer mortality worldwide. Aberrant activation of WNT/β-catenin signaling present in the vast majority of CRC cases is indispensable for CRC initiation and progression, and thus is a promising target for CRC therapeutics. Hispolon is a fungal-derived polyphenol with a pronounced anticancer effect.
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