Clopidogrel delays and can reverse diabetic nephropathy pathogenesis in type 2 diabetic mice.

Background: Diabetic nephropathy (DN) is the principal cause of end-stage renal disease. Previous studies have shown that clopidogrel can prevent the early progression of renal injury.

Aim: To elucidate whether clopidogrel is beneficial against DN by using a / mouse model.

Effects and Mechanism of Polysaccharides in the Treatment of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats.

polysaccharides (GLP) have renal protection effect but there was no study on the diabetic nephropathy. This study was designed to investigate its effect and mechanism using a diabetic rat model induced by streptozotocin (50 mg/kg, i.p.

Effects of spore powder of ganoderma lucidum on CaSR and apoptosis-related proteins in hippocampus tissue of epilepsy following dementia: A protocol of systematic review.

Background: This study will investigate the effects of Spore Powder of Ganoderma Lucidum (SPGL) on CaSR and apoptosis-related proteins (ARP) in hippocampus tissue of epilepsy following dementia.

Methods: This study will retrieve all potential studies from both electronic databases (Cochrane Library, EMBASE, MEDLINE, CINAHL, AMED, and CNKI) and other literature sources to assess the effects of SPGL on CaSR and ARP in hippocampus tissue of epilepsy following dementia. We will search all literature sources from the inception to the present.

Can cervical vascular ultrasound combined with transcranial Doppler ultrasound accurately diagnose cerebral infarction?: A protocol for a systematic review and meta-analysis.

Background: The purpose of this study is to investigate the impact of cervical vascular ultrasound (CVU) combined transcranial Doppler ultrasound (TDU) in the diagnosis of cerebral infarction (CI).

Methods: The following electronic databases will be sought from PUBMED, EMBASE, Cochrane Library, PSYCINFO, Web of Science, Allied and Complementary Medicine Database, WANGFANG, VIP database, and China National Knowledge Infrastructure. The search period will cover from the initial indexing to March 1, 2020 without restrictions of language and publication status.

Impact of early diagnosis of carotid artery stenosis by carotid ultrasound: A protocol of systematic review and meta-analysis.

Background: The purpose of this study is to explore the impact of carotid ultrasound (CU) for early diagnosis of carotid artery stenosis (CAS).

Methods: Literatures will be sought from the following electronic databases: MEDLINE, EMBASE, Cochrane Library, PSYCINFO, Web of Science, Allied and Complementary Medicine Database, and China National Knowledge Infrastructure. The search will cover from the start of indexing to the present without any limitations of language and publication status.

Spore powder of Ganoderma lucidum for Alzheimer's disease: A protocol for systematic review.

Background: Previous studies have reported that spore powder of Ganoderma lucidum (SPGL) may be effective for the treatment of Alzheimer's disease (AD). However, its efficacy is still inconclusive. Thus, this systematic review will aim to assess its efficacy and safety for AD.

Spore powder of Ganoderma lucidum for the treatment of Alzheimer disease: A pilot study.

Background: This study explored the feasible efficacy and safety of the Spore Powder of Ganoderma Lucidum (SPGL) for treating patients with Alzheimer disease (AD).

Methods: Forty-two eligible patients with AD were recruited. These patients were randomly allocated to an intervention group and a control group equally.

[Effect of electroacupuncture pre-treatment on myocardial enzyme levels in recurrent myocardial ischemia rabbits].

Objective: To observe the effect of electroacupuncture (EA) preconditioning of "Neiguan" (PC 6) on myocardial enzyme levels in acute recurrent myocardial ischemia rabbits so as to study its mechanisms underlying protection of ischemic myocardium.

Methods: A total of 40 healthy rabbits were randomized into normal control, myocardial ischemia (MI) model, EA preconditioning (EA-P), recurrent MI (RMI), EA-P+ RMI groups. MI model was duplicated by auricular intravenous administration of Posterior Pituitary Injection (PPI, 0.

Investigation of morphological change of green tea polysaccharides by SEM and AFM.

The objective of this study is to investigate the morphological structure and its change of green tea polysaccharides (GTPS) before and after enzyme reaction by scanning electron microscope (SEM) and atomic force microscope (AFM). Before enzyme reaction, with the novel sample preparation method SEM images of GTPS have obtained many branches and network structures. After enzyme reaction, the morphological structure of GTPS changed, and surface roughness increased.

DsRNA-free transmissible hypovirulence associated with formation of intra-hyphal hyphae in Botrytis cinerea.

A spontaneous mutant CanBc-3HV and its parental strain CanBc-3 of Botrytis cinerea were investigated in terms of pathogenicity, colony morphology, hypovirulence transmissibility, presence of double-stranded RNA (dsRNA), and formation of intra-hyphal hyphae (IH). Results showed that inoculation of CanBc-3HV on detached leaves of Brassica napus did not produce any visible necrotic lesions (20°C, 72h), whereas inoculation of CanBc-3 caused necrotic leaf lesions. Compared to CanBc-3, CanBc-3HV grew slowly, formed numerous mycelial sectors, sporulated sporadically and failed to produce sclerotia on potato dextrose agar (PDA) (20°C, 15d).

[Periodic fluctuation features of air temperature, precipitation, and aboveground net primary production of alpine meadow ecosystem on Qinghai-Tibetan Plateau].

With Mexican Hat function as mother function, a wavelet analysis was conducted on the periodic fluctuation features of air temperature, precipitation, and aboveground net primary production (ANPP) in the Alpine Meadow Ecosystem Research Station, Chinese Academy of Sciences from 1980 to 2007. The results showed that there was a main period of 13 years for the annual fluctuations of air temperature, precipitation, and ANPP. A secondary period of 2 years for the annual fluctuations of air temperature and ANPP had lesser influence, whereas that of 4 years for the annual fluctuation of precipitation had greater effect.

Role of secondary structures in the gelation of porcine myosin at different pH values.

Secondary structures, gelation properties and their relationships in porcine myosin were studied by circular dichroism, dynamic rheological measurement and scanning electron microscopy. Gelling of porcine myosin involved a change in myosin conformation with protein-protein and protein-water interactions. The gelation properties were strongly pH and temperature dependent.

[Comparison of two surgical approach for cardiac cancer].

Objective: To explore the preferable surgical approach for cardiac cancer.

Methods: One hundred and sixty patients with cardiac cancer underwent operation in two surgical approaches (epigastrium and left chest). Analysis was conducted on lymph nodes resected, stump positive rate, radical resectability rate, perioperative mortality, surgical complication rate, postoperative hospital days, survival rate between the two groups.

Vulnerability of synaptic plasticity in the complexin II knockout mouse to maternal deprivation stress.

The alterations in brain function and structure seen in schizophrenia are mediated by genetics as well as vulnerability due to environmental factors. Postmortem studies in schizophrenic patients have shown that expression of complexin II, which is involved in neurotransmitter release at central nervous system synapses, is decreased in the brain. We examined the physiological characteristics of complexin II gene-deficient mice subjected to maternal deprivation stress to determine whether psychological stress during the early stage of life affected the development of brain function.

[Exploration on the mother edition of Wang Bing's annotated Su wen (Plain questions)].

According to Wang Bing's preface, when arranging Su wen (Plain Questions), he applied different editions of the book. But, he didn't indicate which edition was applied as the mother edition. By analyzing materials from Wang's preface, newly produced Plain Questions, etc.