Publications by authors named "Li-Hong Ao"
Advances in macrophage-myofibroblast transformation in fibrotic diseases.
Front Immunol
October 2024
Article Synopsis
- Macrophage-myofibroblast transformation (MMT) is a key process in the development of organ fibrosis after damage, as macrophages turn into myofibroblasts and contribute to fibrosis formation.
- Recent research has focused on understanding how MMT occurs, including the origins of myofibroblasts and the specific mechanisms involved in fibrotic diseases affecting various organs.
- This article summarizes important findings related to MMT, aiming to shed light on the mechanisms of fibrosis and potentially inform the development of new treatments for fibrotic diseases.
Excessive exposure to manganese in the environment or workplace is strongly linked to neurodegeneration and cognitive impairment, but the precise pathogenic mechanism and preventive measures are still not fully understood. The study aimed to investigate manganese -induced oxidative damage in the nervous system from an epigenetic perspective, focusing on the H3K36ac-dependent antioxidant pathway. Additionally, it sought to examine the potential of curcumin in preventing manganese-induced oxidative damage.
View Article and Find Full Text PDFSilicon dioxide nanoparticles (SiNPs) are one of the major forms of silicon dioxide and are composed of the most-abundant compounds on earth. Based on their excellent properties, SiNPs are widely used in food production, synthetic processes, medical diagnostics, drug delivery, and other fields. The mass production and wide application of SiNPs increases the risk of human exposure to SiNPs.
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