[Puerarin Inhibits the Proliferation,Invasion,and Migration of Non-small Cell Lung Cancer Cells through Regulating miR-490/Denticleless E3 Ubiquitin Protein Ligase].

Objective To explore the mechanism of puerarin inhibiting the proliferation,invasion,and migration of non-small cell lung cancer cells. Methods A549 cells were cultured and treated with different concentrations of puerarin.The inhibition rate (IR) on cell proliferation was detected by CCK-8,and qRT-PCR was performed to detect the mRNA levels of miR-490 and denticleless E3 ubiquitin protein ligase(DTL).

An integrated optimization mode for multi-type aircraft flight scheduling and routing problem.

This paper proposes an optimization model for the integrated aircraft flight scheduling and routing problem, which allows a simultaneous determination of the departure time of each flight trip and assignment of a set of aircraft located at different airports to perform all flight trips. The proposed model envisages that each flight trip is covered by its own particular aircraft type or a larger airplane. Further, departure and arrival times of each flight trip are within a flexible time window in its aircraft's route and origin/destination airports, and the number of airplanes firstly distributed in the base airports is fully accounted for in the model.

Two ,'-bis-(pyridin-4-yl)pyridine-2,6-dicarboxamide coordination compounds.

The molecular structures of tetra-aqua-[,'-bis-(pyridin-4-yl)pyridine-2,6-dicar-boxamide]-sulfatomanganese(II) dihydrate, [Mn(SO)(CHNO)(HO)]·2HO or [Mn(H)(SO)(HO)]·2HO, (I), and tetra-aqua-bis[,'-bis-(pyridin-4-yl)pyridine-2,6-dicar-boxamide]cadmium(II) sulfate tetra-hydrate, [Cd(CHNO)(HO)]SO·4HO or [Cd(HO)(H)]·SO·4HO, (II), both contain a central metal atom in a distorted octa-hedral geometry coordinated equatorially by four oxygen atoms from water mol-ecules. In (I), the axial positions are occupied by a nitro-gen atom from H and an oxygen atom from the sulfate anion, whereas in (II), the axial positions contain two nitro-gen atoms from two different H ligands and the sulfate anion acts as the charge-balancing ion. π-π stacking between pyridine rings and a network of hydrogen bonds involving the water molecules and the sulfate anions play a crucial role in the mol-ecular self-assembly of the two structures.

The CCND1 G870A gene polymorphism and leukemia or non-Hodgkin lymphoma risk: a meta-analysis.

Unlabelled: In recent years, mounting evidence has indicated that the CCND1 G870A gene polymorphism, which impacts the mitotic cell cycle, may influence leukemia or non-Hodgkin lymphoma risk. Unfortunately, the previous results were inconsistent. Therefore, a meta-analysis was performed to obtain a more precise estimation of any association.

The CCND1 G870A gene polymorphism and brain tumor risk: a meta-analysis.

Background: In recent years, numerous studies have been performed to investigate the CCND1 G870A gene polymorphism impact on brain tumors susceptibility. Unfortunately, the results of previous studies were inconsistent. Therefore, we performed a meta-analysis to derive a more precise estimation of any association.

Design and in vivo evaluation of an indapamide transdermal patch.

The aim of the present study was to develop and evaluate a novel drug-in-adhesive transdermal patch system for indapamide. Initial in vitro experiments were conducted to optimize formulation parameters prior to transdermal delivery in rats. The effects of the type of adhesive and the content of permeation enhancers on indapamide transport across excised rat skin were evaluated.