Steroid-resistant nephrotic syndrome caused by nuclear pore gene NUP133 variation.

Partially enlarged structure of NUP133: wild-type (upper) and mutant p.Lys966Asn (lower).

[Summary on 's experience in clinical treatment of spasmodic torticollis].

The thinking and experience of professor - in the treatment of spasmodic torticollis under the guidance of 's academic thoughts are introduced. In pathogenesis, spasmodic torticollis is related to the obstruction of circulation and malnutrition of tendons and vessels. "Promoting and benefiting " is considered as the main treating principle.

[Analysis of Clinical Characteristics of Acute B Lymphoblastic Leukemia with EP300-ZNF384 Fusion Gene Positive].

Objective: To investigate the clinical manifestations and laboratory features of B-ALL patients with EP300-ZNF384 fusion gene positive, so as to improve the understanding of this subtype disease.

Methods: The clinical data of 3 B-ALL patients with EP300-ZNF384 fusion gene positive admitted in Department of Hematology, the first medical center of Chinese PLA general hospital from February 2017 to February 2018 were collected and analyzed retrospectively. The clinical and laboratory characteristics as well as the therapentic outcome in B-ALL patients with EP300-ZNF384 fusion gene positive were analyzed.

Carboxylated carbon nanospheres as solid-phase extraction adsorbents for the determination of perfluorinated compounds in water samples by liquid chromatography-tandem mass spectrometry.

This work demonstrates the extraction potential of carboxylated carbon nanospheres (CNSs-COOH) for solid-phase extraction of perfluoroalkyl acids (PFAAs) for the first time. Six PFAAs, including perfluorohexanesulfonate (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorooctanoic sulfonic (PFOS), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA), were quantitatively adsorbed on a CNSs-COOH-packed cartridge; then, the PFAAs retained on the adsorbent were quantitatively eluted with an optimized volume of acetone (pH = 10). Finally, the desorbed PFAAs were determined by liquid chromatography-tandem mass spectrometry.

[Zhu Lian's characteristics and experiences in clinical practice of acupuncture and moxibustion].

This paper aims at discussing the clinical characteristics and experiences of ZHU Lian, the renowned contemporary acupuncture master from the following three aspects: "characteristics of clinical manipulations and techniques", "thoughts on diagnosis and treatment" and "examples of clinical cases". The study has shown that ZHU Lian invented the slow insertion technique by rotating needle and the embedding needle technique, improved moxibustion technique with moxa roll and proposed the three keys on the treatment with acupuncture and moxibustion, as well as discovered new acupoints for treatment. The pioneering and distinguished achievements she con tributed play the great demonstrating and driving role in the development of clinical study and practice of acupuncture and moxibustion.

Silicon-based bulky group-induced remote control and conformational preference in the synthesis and application of isolable atropisomeric amides with secondary alcohol or amine moieties.

Remote stereocontrol through conformational transmission along a carbon chain is highly important in synthetic systems and molecular architectures. In this work, the interactional reactivity between a remote silicon-based bulky group and an O-/N-containing functional group has been revealed and determined by lateral lithiation-substitution, desilylation, as well as desilylation-olefination with benzaldehyde. The results suggest considerable information transmission and steric hindrance that can be exploited for the controllable synthesis of atropisomeric molecules.

Ionic liquid/ionic liquid dispersive liquid-liquid microextraction.

In this article, a novel and simple microextraction method, termed ionic liquid/ionic liquid dispersive liquid-liquid microextraction (IL/IL-DLLME), has been designed and developed for the rapid enrichment and analysis of environmental pollutants. Instead of using hazardous organic solvents, two kinds of ILs, hydrophobic IL and hydrophilic IL, were used as extraction solvent and disperser solvent in IL/IL-DLLME step, respectively. Permethrin and biphenthrin, two of the often-used pyrethroid pesticides, were used as model compounds.

[Brief introduction of academic thought of ZHU Lian, an expert in modern acup-moxibustion science].

ZHU Lian studied medicine from 17 years old and studied acup-moxibustion from October 1944. She raised the principle of acupuncture and moxibustion treating diseases in the middle period of the last century, "Acupuncture-moxibustion mainly stimulates and regulates human nerve system, particularly, regulative function and control function of high central nerve system including the cerebral cortex, so as to cure diseases". Also, she first put forward 3 keys of acupuncture-moxibustion treating diseases, stressed aseptic manipulation, and originated a safe needle-retaining method, finger-pressure therapy and maxo roll moxibustion; she found 19 new acupoints.