Diagnosis and treatment recommendations for glucose transporter 1 deficiency syndrome.

Background: Glucose transporter 1 deficiency syndrome (Glut1DS) was initially reported by De Vivo and colleagues in 1991. This disease arises from mutations in the SLC2A1 and presents with a broad clinical spectrum. It is a treatable neuro-metabolic condition, where prompt diagnosis and initiation of ketogenic dietary therapy can markedly enhance the prognosis.

Alantolactone suppresses the metastatic phenotype and induces the apoptosis of glioblastoma cells by targeting LIMK kinase activity and activating the cofilin/G‑actin signaling cascade.

Glioblastoma (GBM) is the most common aggressive brain tumor and is associated with an extremely poor prognosis, as the current standard of care treatments have limited efficacy. Natural compounds have attracted increasing attention as potential anticancer drugs. Alantolactone (ATL) is a natural small molecule inhibitor, that has antitumor properties.

[Effects of light intensity on growth and content of active components of Uncaria rhynchophyll].

The aim of this study was to study the effects of different light intensity on the growth,biomass accumulation and distribution,chlorophyll content and effective components of Uncaria rhynchophylla seedlings,and explore the suitable light intensity conditions for artificial cultivation of U. rhynchophylla seedlings. Three-year-old U.

Upper gastrointestinal hemorrhage and thoracic aortic aneurysm rupture as presenting signs of Behçet disease: A case report.

Introduction: Behçet disease (BD) is an autoimmune disorder characterized by oral aphthosis, genital aphthosis, ocular lesions, and arthritis. However, other fatal complications are often misdiagnosed, which implies that the early diagnosis of the disease is important for a good prognosis.

Patient Concerns: A 51-year-old man complained of hematemesis for 5 hours and syncope once.

Clinical Characteristics and Outcomes of Pediatric Cerebral Venous Sinus Thrombosis: An Analysis of 30 Cases in China.

Cerebral venous sinus thrombosis (CVST) in children is rare in a clinical setting. The aim of this study was to summarize the etiological, clinical, and imaging characteristics of CVST in children. We retrospectively analyzed the data of 30 patients with a diagnosis of CVST who were admitted to Children's Hospital of Fudan University from 2008 to 2018.

QED cascade saturation in extreme high fields.

Upcoming ultrahigh power lasers at 10 PW level will make it possible to experimentally explore electron-positron (ee) pair cascades and subsequent relativistic ee jets formation, which are supposed to occur in extreme astrophysical environments, such as black holes, pulsars, quasars and gamma-ray bursts. In the latter case it is a long-standing question as to how the relativistic jets are formed and what their temperatures and compositions are. Here we report simulation results of pair cascades in two counter-propagating QED-strong laser fields.

Six-month efficacy of the Ketogenic diet is predicted after 3 months and is unrelated to clinical variables.

Objective: The aim of this study was to evaluate the 6-month efficacy of a Ketogenic diet (KD) in children with drug-resistant epilepsy and to analyze the associated factors that affect the efficacy of a KD.

Methods: Eighty-seven pediatric patients with drug-resistant epilepsy who followed a KD for at least 6 months were included in this study. The efficacy of a KD was assessed based upon the seizure frequency, as recorded by parents and caregivers.

Tunable synchrotron-like radiation from centimeter scale plasma channels.

Synchrotron radiation (SR) sources are immensely useful tools for scientific researches and many practical applications. Currently, the state-of-the-art synchrotrons rely on conventional accelerators, where electrons are accelerated in a straight line and radiate in bending magnets or other insertion devices. However, these facilities are usually large and costly.

Prostate cancer identification: quantitative analysis of T2-weighted MR images based on a back propagation artificial neural network model.

Computer-aided diagnosis (CAD) systems have been proposed to assist radiologists in making diagnostic decisions by providing helpful information. As one of the most important sequences in prostate magnetic resonance imaging (MRI), image features from T2-weighted images (T2WI) were extracted and evaluated for the diagnostic performances by using CAD. We extracted 12 quantitative image features from prostate T2-weighted MR images.

Optimal contouring of seminal vesicle for definitive radiotherapy of localized prostate cancer: comparison between EORTC prostate cancer radiotherapy guideline, RTOG0815 protocol and actual anatomy.

Background: Intermediate- to-high-risk prostate cancer can locally invade seminal vesicle (SV). It is recommended that anatomic proximal 1-cm to 2-cm SV be included in the clinical target volume (CTV) for definitive radiotherapy based on pathology studies. However, it remains unclear whether the pathology indicated SV extent is included into the CTV defined by current guidelines.

[Changes of foliar delta13C value of Quercus fabric in different root underground habitat types in Karst area].

Selecting the dominant tree species Quercus fabric in three root underground habitat types (the dolomites of low oblique occurrence with multilayer space, middle oblique occurrence with multilayer space, and high oblique occurrence with multilayer space) in Karst area as test object, this paper studied the foliar delta13C value and its correlations with habitat soil conditions, and the plant water use efficiency. There existed remarkable differences in the foliar delta13C value of Q. fabric among the three habitat types, being decreased in the order of low oblique occurrence with multilayer space type (-26.

[Characteristics of soil microbial biomass carbon and soil water soluble organic carbon in the process of natural restoration of Karst forest].

By the method of taking space instead of time, an incubation test was conducted to study the characteristics of soil microbial biomass carbon and water soluble organic carbon in the process of natural restoration of Karst forest in Maolan Nature Reserve, Guizhou Province of Southwest China. The soil microbial biomass carbon content and soil basal respiration decreased with increasing soil depth but increased with the process of the natural restoration, soil microbial quotient increased with increasing soil depth and with the process of restoration, and soil water soluble organic carbon content decreased with increasing soil depth. In the process of the natural restoration, surface soil water soluble organic carbon content increased, while sublayer soil water soluble organic carbon content decreased after an initial increase.

[Characteristics of soil mineralizable carbon pool in natural restoration process of Karst forest vegetation].

By the method of taking space instead of time, an incubation test was conducted to study the characteristics of soil mineralizable carbon pool during the natural restoration of Karst forest vegetation in Maolan Nature Reserve, Guizhou Province of Southwest China. It was observed that the contents of soil total organic carbon (TOC) and mineralizable carbon (MC) as well as the carbon mineralization rate decreased with increasing soil depth but increased with the process of vegetation restoration. The amount of cumulative released carbon and the carbon release rate increased with the process of restoration, but the release rate decreased with increasing incubation time.

Influence of drought intensity on the response of six woody karst species subjected to successive cycles of drought and rewatering.

Tolerance to the effects of drought and subsequent recovery after a rainfall appear to be critical for plants in the karst regions of southwestern China, which are characterized by frequent but temporary drought events. This study investigated the effects of drought intensity and repetition on photosynthesis and photoprotection mechanisms of karst plants during successive cycles of drought and subsequent recovery. Leaf water potential, gas exchange, chlorophyll fluorescence and several associated metabolic processes were studied in six plant species, including Pyracantha fortuneana (PF), Rosa cymosa (RC), Broussonetia papyrifera (BP), Cinnamomum bodinieri (CB), Platycarya longipes (PL) and Pteroceltis tatarinowii (PT) during three cycles of drought treatments at four different intensities.

[Analysis of the clinical information of 1,066 cases undergoing prostate magnetic resonance examination].

Objective: To evaluate the variation of clinical data and referred purpose of prostate magnetic resonance (MR) examination in the past 12 years in Peking University First Hospital.

Methods: One thousand and sixty-six patients underwent prostate MR examination (1,296 exams) from May 1992 to Sept. 2004.