LncRNA AL645608.3 mediates malignant progression of acute myeloid leukemia.

Objective: To investigate the role of lncRNA AL645608.3 in the malignant progression of acute myeloid leukemia (AML) cells and explore relevant molecular mechanisms.

Methods: The expression level of AL645608.

Fluorescence quenching study of 2,6-bis(5-(4-methylphenyl)-1-H-pyrazol-3-yl)pyridine with metal ions.

A novel bispyrazole derivative 2,6-bis(5-(4-methylphenyl)-1-H-pyrazol-3-yl)pyridine was synthesized and its structure was confirmed by (1)H NMR, FTIR, MS techniques and elemental analysis. The binding interactions of BMPP with Cd(2+), Co(2+), Pb(2+) and Cu(2+) ions were investigated in MeOH-H2O solution by fluorescence quenching technique at two temperatures (25 and 35°C). Their quenching constants KSV, binding constants K, binding sites n and thermodynamic parameters (ΔH, ΔG and ΔS) were determined.