Publications by authors named "Li-Fan Dong"
Article Synopsis
- This study investigates how calcium deposits in human saphenous veins relate to endothelial function and demographic risk factors, using samples collected during coronary artery bypass graft surgery.
- Out of 54 vein segments studied, 29.6% showed calcium deposits, which were linked to greater intimal thickness and compromised endothelial relaxation compared to non-calcified veins.
- Significant patient risk factors for calcium deposition included older age and higher preoperative serum creatinine levels, suggesting a need for further research on how vein calcification affects graft success over time.*
Background: Injury to saphenous vein grafts during surgical preparation may contribute to the subsequent development of intimal hyperplasia, the primary cause of graft failure. Surgical skin markers currently used for vascular marking contain gentian violet and isopropanol, which damage tissue and impair physiologic functions. Brilliant blue FCF (FCF) is a nontoxic dye alternative that may also ameliorate preparation-induced injury.
View Article and Find Full Text PDFImportance: Surgical skin markers are used off-label to mark human saphenous veins (HSVs) to maintain orientation before implantation as aortocoronary or peripheral arterial bypass grafts. These surgical skin markers impair functional responses of the HSV tissue.
Objectives: To investigate the effect of brilliant blue dye 1 (brilliant blue FCF [for food coloring]; hereinafter, FCF) as a nontoxic alternative marking dye and to determine whether FCF has pharmacological properties.
A systemic analysis on pemetrexed in treating patients with breast cancer.
Asian Pac J Cancer Prev
March 2015
Background: This systemic analysis was conducted to evaluate the efficacy and safety of pemetrexed based chemotherapy in treating patients with metastatic breast cancer as first or second line chemotherapy.
Methods: Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for patients with breast cancer were identified using a predefined search strategy. Pooled response rate (RR) of treatment were calculated.
Article Synopsis
- - The long-term success of using human saphenous veins (HSVs) as grafts for coronary artery bypass surgeries is hindered by a high rate of vein graft failure, which can lead to serious health issues such as heart attacks and additional surgeries.
- - This study explored if applying controlled pressure during vein preparation causes endothelial damage and intimal thickening and whether a pressure release valve (PRV) can help maintain endothelial function.
- - Results indicated that pressure distension of HSVs led to significantly reduced endothelial relaxation, suggesting that without pressure control, vein grafts may be more prone to complications post-surgery.
Introduction: Human saphenous vein (HSV) is the most widely used bypass conduit for peripheral and coronary vascular reconstructions. However, outcomes are limited by a high rate of intimal hyperplasia (IH). HSV undergoes a series of ex vivo surgical manipulations prior to implantation, including hydrostatic distension, marking, and warm ischemia in solution.
View Article and Find Full Text PDFBackground: Intimal hyperplasia is a complex process thought to be initiated by injury and is the leading cause of vein graft failure. In the present investigation, we hypothesized that the basal intimal thickness in the human saphenous vein is a predictor of endothelial dysfunction and, potentially, intimal hyperplasia.
Methods: Human saphenous veins were obtained during coronary artery bypass surgery.
The aim of this retrospective study was to evaluate a sacroplasty technique, using three-dimensional C-arm CT reformation combined with fluoroscopic guidance for patients with severe painful sacral metastases. We studied the data of seven patients (average age 55.7 years) treated through trans-sacroiliac joint approach with the technique.
View Article and Find Full Text PDFObjective: To evaluate effects of vertebroplasty on restoration of vertebral body height and wedge angle and relief from pain in patients with osteoporotic compression fractures.
Methods: A retrospective study of 156 patients (232 levels) who had undergone vertebroplasty was conducted. Treated vertebrae with cleft included 49 patients (49 levels) and that without cleft 107 patients (183 levels).
Background: Recently, bilateral transpedicular kyphoplasty with a single balloon was performed for osteoporotic vertebral body compression fractures (OVCFs) to reduce the fees of the operation, but the time of operation and radiation exposure are longer. The aim of this study was to determine the safety and effectiveness of a single balloon cross-midline expansion via unipedicular approach in kyphoplasty for OVCFs.
Methods: Thirty-six patients with painful OVCFs (61 vertebrae) were enrolled in this research.
Objective: To evaluate the clinical efficacy of percutaneous bipediculary kyphoplasty with double or single balloon I treatment of osteoporosis vertebral compressive fractures.
Methods: Fifty-one patients with painful osteoporotic vertebral compressive fracture involving 69 vertebrae. 19 males and 32 females, aged 72.
Objective: To explore the effects of coronary abnormalities on reconstruction of right ventricular outflow tract in patients with complex congenital heart disease.
Methods: Eighty patients, including tetralogy of Fallot 14 cases and double outlet right ventricle (DORV) 4 cases with anomalous coronary artery, underwent surgical treatment from April 1989 to May 2004. The coronary diseases included single left or right coronary artery in 11 cases, left anterior descending coronary artery originating from right coronary artery in 6 cases, vascular plexus on right outflow tract in 1 case.