Publications by authors named "Li-Duan Tan"
Article Synopsis
- Bone is a major site for breast cancer metastasis, with cancer cells mimicking bone-forming cells (osteoblasts) by expressing specific bone-related genes (BRGs).
- This mimicry occurs through a transformation process involving epithelial-mesenchymal transition (EMT) and stimulation by bone morphogenetic protein-2 (BMP2).
- The transcription factor RUNX2 plays a crucial role in regulating the expression of BRGs, impacting the cancer cells' ability to migrate, adhere, proliferate, and resist drugs in a bone-like environment.
Human epidermal growth factor receptor 2 (HER2) is one of the most important prognostic and predictive factors for breast cancer patients. Recently, serum HER2 ECD level of patients detected by enzyme-linked immunoabsorbent assay (ELISA) has been shown to predict tumor HER2 status and reveal its association with tumor progression, recurrence and poor prognosis. In this study, we established a new method, dot blot assay, to measure the serum HER2 level in breast cancer patients and further to evaluate the clinical value for monitoring breast cancer progression.
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