Effect of Hepatocyte Growth Factor-Transfected Human Umbilical Cord Mesenchymal Stem Cells on Hepatic Stellate Cells by Regulating Transforming Growth Factor-β1/Smads Signaling Pathway.

Studies have shown that human umbilical cord mesenchymal stem cells (hUCMSCs) could ameliorate liver fibrosis (LF) through inhibiting the activation of hepatic stellate cells (HSCs). However, the specific mechanisms have not been studied clearly. The purpose of this study was to explore the possible mechanism of hepatocyte growth factor (HGF)-transfected hUCMSCs in inhibiting the proliferation and activation of HSCs-T6.

Effect of Human Umbilical Cord Mesenchymal Stem Cells Transfected with HGF on TGF-β1/Smad Signaling Pathway in Carbon Tetrachloride-Induced Liver Fibrosis Rats.

The research on human umbilical cord-derived mesenchymal stem cells (hUCMSCs) suggests promising therapeutic strategy for ameliorating liver fibrosis and it can be an effective alternative method of orthotopic liver transplantation. Hepatocyte growth factor (HGF) is the most basic cytokine involved in the inhibition of liver fibrosis and promotion of hepatocyte proliferation and regeneration. The objective of this study was to determine the possible mechanism about how the microencapsulated hUCMSCs made by alginate-poly-lysine-alginate (A-P-A) transfected with HGF could ameliorate liver fibrosis through the TGF-β1/Smad signaling pathway.

[Epidemic situation of malaria in Dalian City from 2005 to 2016].

Objective: To describe and analyze the epidemiological characteristics of malaria in Dalian City, so as to provide the evidence for adjusting and formulating malaria control strategy and measures, being in accordance with the practical situation in Dalian City.

Methods: The data of malaria cases in Dalian City from 2005 to 2016 were collected from China Diseases Surveillance Information Reporting Management System (DSIRMS), to describe and analyze the epidemiologic characteristics of malaria in Dalian City.

Results: A total of 143 malaria cases were reported in Dalian from 2005 to 2016, including 115 laboratory diagnosed cases, 27 clinically diagnosed cases, and 1 suspected diagnosed case.