Publications by authors named "Li-Chen Chang"
Article Synopsis
- An updated meta-analysis investigated the effects of intravenous iron supplementation on reducing red blood cell (RBC) transfusion risk in adult patients after cardiac surgery, incorporating recent data from 14 randomized controlled trials with a total of 2,043 subjects.
- Results revealed that intravenous iron significantly decreased the likelihood of RBC transfusions (relative risk 0.77) and improved postoperative hemoglobin levels and iron status compared to control groups.
- The findings suggest that integrating intravenous iron supplementation into perioperative care could enhance patient outcomes in blood management without increasing mortality risk.
Article Synopsis
- This meta-analysis investigates how effective a single dose of intravenous steroids is for enhancing postoperative recovery quality in adult surgery patients, using validated QoR scales.
- The study included eleven randomized controlled trials with 951 patients and measured various outcomes, including overall recovery scores and pain management.
- Results show that intravenous steroids significantly improved recovery scores and reduced pain and nausea compared to placebo, suggesting they are beneficial for postoperative care.*
Article Synopsis
- It included seven randomized controlled trials with a total of 622 patients, revealing that magnesium sulfate significantly improved overall recovery scores and specific aspects like pain and physical comfort compared to a placebo
- Additionally, magnesium sulfate also reduced the need for opioids during surgery and lowered instances of postoperative nausea and vomiting, indicating its potential benefits for pain management and patient recovery.
Association between high-dose molnupiravir and COVID-19 mortality rate.
Int J Antimicrob Agents
March 2024
In advanced prostate cancer, CREB (cAMP-responsive element-binding protein) binding protein (CBP) and its homolog EP300 are highly expressed; targeting the bromodomain of CBP is a new strategy for the treatment of prostate cancer. In the current study we identified Y08197, a novel 1-(indolizin-3-yl) ethanone derivative, as a selective inhibitor of CBP/EP300 bromodomain and explored its antitumor activity against prostate cancer cell lines in vitro. In the AlphaScreen assay, we demonstrated that Y08197 dose-dependently inhibited the CBP bromodomain with an IC value at 100.
View Article and Find Full Text PDFLattice Boltzmann simulations of incompressible liquid-gas systems on partial wetting surfaces.
Philos Trans A Math Phys Eng Sci
June 2011
A three-dimensional Lattice Boltzmann two-phase model capable of dealing with large liquid and gas density ratios and with a partial wetting surface is introduced. This is based on a high density ratio model combined with a partial wetting boundary method. The predicted three-dimensional droplets at different partial wetting conditions at equilibrium are in good agreement with analytical solutions.
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