Publications by authors named "Li-Chao Ye"
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-mediated primary inflammatory myelinopathy of the central nervous system that primarily affects the optic nerve and spinal cord. The aquaporin 4 antibody (AQP4-Ab) is a specific autoantibody marker for NMOSD. Most patients with NMOSD are seropositive for AQP4-Ab, thus aiding physicians in identifying ways to treat NMOSD.
View Article and Find Full Text PDFParkinson's disease (PD) is a common age-related neurodegenerative disorder characterized by damage to nigrostriatal dopaminergic neurons. Key pathogenic mechanisms underlying PD include alpha-synuclein misfolding and aggregation, impaired protein clearance, mitochondrial dysfunction, oxidative stress, and neuroinflammation. However, to date, no study has confirmed the specific pathogenesis of PD.
View Article and Find Full Text PDFArticle Synopsis
- Parkinson's disease (PD) is a widespread neurodegenerative disorder marked by the loss of dopaminergic neurons, leading to both motor symptoms (like tremors and stiffness) and non-motor symptoms (such as cognitive issues and fatigue).
- Metabolic syndrome (MetS) encompasses various health conditions like obesity, hypertension, and diabetes, which are linked to chronic diseases and share several biological processes with PD, including oxidative stress and inflammation.
- Recent studies suggest that MetS increases the risk of developing PD, and certain metabolic therapies may offer promising preventative and therapeutic benefits for those at risk.
Parkinson's disease (PD) has become the second largest neurodegenerative disease after Alzheimer's disease, and its incidence is increasing year by year. Traditional dopamine replacement therapy and deep brain stimulation can only alleviate the clinical symptoms of patients with PD but cannot cure the disease. In recent years, stem cell therapy has been used to treat neurodegenerative diseases.
View Article and Find Full Text PDF[Clinical Features of Neuromyelitis Optica Spectrum Disorders with Connective Tissue Diseases].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
April 2021
Objective To investigate the clinical features of neuromyelitis optica spectrum disorders(NMOSD)with connective tissue diseases(CTD). Methods Clinical data of 16 NMOSD-CTD patients and 54 NMOSD patients admitted to the Second Affiliated Hospital of Fujian Medical University from January 2015 to February 2020 were collected.The initial symptom,intracranial lesion,spinal cord lesion,laboratory examination and treatment response were compared between the two groups.
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