Clinical analysis of 2790 children with retinoblastoma: a single-center experience in China.

Background: In this study, we aimed to analyze the clinical characteristics and prognosis of children with retinoblastoma (RB) in a single center in China with a large sample collection spanning 17 years.

Methods: The clinical data of 2790 children with RB treated in Beijing Tongren Hospital from 2005 to 2021 were collected, and a retrospective analysis was conducted.

Results: The median age of the participants was 28.

Cryptococcal antigen testing of lung tissue homogenate improves pulmonary cryptococcosis diagnosis: Two case reports.

Background: Pulmonary cryptococcosis (PC) is an opportunistic infectious disease of the respiratory system. Lung tissue biopsies, culture of respiratory samples (., sputum, lung tissue, pleural fluid, and bronchoalveolar lavage fluid), and cryptococcal antigen (CrAg) testing are helpful for a definitive diagnosis.

Prognosis Analysis and Clinical Features of Orbital Cavernous Venous Malformations With Refractory Insidious Onset.

Objective: The present study aims to analyse the clinical presentation, treatment and prognosis of a group of patients with orbital cavernous venous malformation (OCVM) with an insidious onset.

Method: The clinical data of 35 patients with OCVM treated at our centre between 2003 and 2020 were retrospectively analysed. The OCVMs were classified as one of six types (I-VI) according to the orbital position of the tumour.

Value of eosinophil count in bronchoalveolar lavage fluid for diagnosis of allergic bronchopulmonary aspergillosis: A case report.

Background: An immediate hypersensitive immune response to antigens is one of the main characteristic features of allergic bronchopulmonary aspergillosis (ABPA). As ABPA is an allergic respiratory disease, immunoglobulin E and peripheral-blood eosinophilia have been used as diagnostic indicators. However, eosinophilia in bronchoalveolar lavage fluid (BALF) has not been considered in the diagnostic criteria for ABPA.

Chronic myeloid leukemia following repeated diagnostic X-ray exposure for the treatment of recurrent spontaneous pneumothorax in a patient with ankylosing spondylitis: A case report and literature review.

Previous studies have indicated that X-ray irradiation may increase the risk of chronic myeloid leukemia (CML), and the incidence of spontaneous pneumothorax in patients with ankylosing spondylitis (AS) is higher than in the general population. Patients with AS usually develop spontaneous pneumothorax several years after the diagnosis of AS. The present study reports the unusual case and complicated clinical history of a 29-year-old man with recurrent pneumothorax and AS, who developed CML following repeated exposure to low doses of radiation via diagnostic X-rays and chest computed tomography imaging.

Hepatitis B virus upregulates host expression of α-1,2-mannosidases the PPARα pathway.

Aim: To assess the effects of hepatitis B virus (HBV) on the expression of host α-1,2-mannosidases and determine the underlying mechanisms.

Methods: We measured the expression levels of MAN1A1, MAN1A2, MAN1B1, and MAN1C1 in cell lines HepG2.2.

CONGENITAL CONTRACTILE PERIPAPILLARY STAPHYLOMA WITH RHEGMATOGENOUS RETINAL DETACHMENT.

Purpose: To describe the occurrence of a congenital contractile peripapillary staphyloma in association with a rhegmatogenous retinal detachment.

Methods: The clinical course of a 17-year-old patient with a contractile peripapillary staphyloma and undergoing pars plana vitrectomy for repair of an associated retinal detachment was studied.

Results: The left eye showed a peripapillary staphyloma which during the ophthalmoscopical examination revealed contractile movements after the presentation of a light stimulus to either eye.

Chronic myeloid leukaemia following repeated exposure to chest radiography and computed tomography in a patient with pneumothorax: A case report and literature review.

It is well known that radioactive rays may cause damage to the human body. Progress in modern medicine has led to an increased risk of therapeutic and diagnostic radiation exposure of patients. Although clear evidence of a radiation dose-dependent risk of chronic myeloid leukaemia, particularly for patients exposed to radiation at a young age, has been established, it is not known whether radiation exposure during diagnostic imaging also increases the risk of cancer.

Neuroprotective Effect of Compound Anisodine in a Mouse Model with Chronic Ocular Hypertension.

Background: Compound anisodine (CA) is a compound preparation made from hydrobromide anisodine and procaine hydrochloride. The former is an M-choline receptor blocker with the function of regulating the vegetative nervous system, improving microcirculation, and so on. The latter is an antioxidant with the activities of neuroprotection.

Surgical Indications of Exploring Optic Canal and Visual Prognostic Factors in Neurosurgical Treatment of Tuberculum Sellae Meningiomas.

Background: Tuberculum sellae meningiomas (TSMs) present a special symptom because of the adherence and compression to the optic nerve, optic artery, and the chiasm. A significant number of patients with TSMs appear visual deficits. This study aimed to investigate the surgical indications of exploring the optic canal and visual prognostic factors in the neurosurgical treatment of TSMs.

[Clinical analysis of acute zonal occult outer retinopathy masquerading as optic neuropathy].

Objective: To analyze the clinical features of acute zonal occult outer retinopathy (AZOOR) and the reasons for misdiagnosing as optic neuropathy or intracranial lesions.

Methods: Case series study. Twenty patients (23 eyes) who were all initially diagnosed as optic neuropathy or intracranial lesions were recruited in the ophthalmologic department of Beijing Tongren Hospital from November 2003 to June 2012, but they were ultimately diagnosed as AZOOR after the examinations including regular eye examination, fundus fluorescein angiography (FFA), optical coherence tomography (OCT), automatic perimetry, flash electroretinogram (F-ERG),multifocal electroretinogram (mfERG),systemic rheumatism immunological examination and neuroimaging.

Clinical features of retinal diseases masquerading as retrobulbar optic neuritis.

Background: Managements of optic neuritis (ON) included high-dose corticosteroids or combined with systemic immunomodulatory agents. It was important to make a correct diagnosis of ON before initiation of treatment. The purpose of the study was to report and analyze the clinical features of retinal diseases in patients who were misdiagnosed as having retrobulbar ON.

[Pyopneumothorax caused by Salmonella choleraesuis: a case report and review of the literature].

Objective: To improve understanding of the clinical features, diagnosis and treatment of pyopneumothorax caused by Salmonella choleraesuis.

Methods: One case of pyopneumothorax caused by Salmonella choleraesuis diagnosed and treated in our hospital in 2010 was reported and the related literatures were reviewed. As of May 2011, the literature review was carried out with "Salmonella choleraesuis" and "thoracic empyema" as the search terms in Wanfang Med Online and Pubmed Database.

[Clinical analysis of occult macular dystrophy].

Objective: To report the clinical features of occult macular dystrophy (OMD).

Methods: It was a retrospective case series study. 9 cases (14 eyes) with 3 males, 6 females, mean age 36 (7 to 53) years, were examined with vision acuity, fundus ophthalmoscope, fundus fluorescein angiography (FFA), electroretinogram (ERG), visual evoked potential (VEP), multifocal electroretinogram (mfERG) and optical coherence tomography (OCT).

[The impact of right ventricular dysfunction on the clinical outcome of normotensive patients with pulmonary embolism].

Objective: To investigate the prevalence and clinical outcome of right ventricular (RV) dysfunction among normotensive PE patients.

Methods: Inclusion criteria included: (1) Confirmed PE at Sir Run Run Shaw Hospital from January 2001 to December 2004. (2) Normotensive.

[Pulmonary cryptococcosis: analysis of nine cases].

Objective: To investigate the diagnosis and treatment of pulmonary cryptococcosis.

Methods: A total of 9 cases of pulmonary cryptococcosis, diagnosed at Sir Run Run Shaw Hospital of Zhejiang University from January 2002 to August 2004, identified by pathological examinations, were retrospectively studied.

Results: The patients consisted of 7 males and 2 females aged from 28 to 69 years.