Influence of Body Mass Index on the Clinicopathological Features of Papillary Thyroid Carcinoma in a Chinese Population.

Previous studies suggested a relationship between obesity and a high risk of thyroid cancer. However, the association between high body mass index (BMI) and the aggressiveness of papillary thyroid carcinoma (PTC) is controversial. In this study, we aimed to investigate the impact of excess BMI on histopathologic aggressiveness of PTC in a Chinese population.

Developing Topics.

Background: To investigate the effects of 40 Hz high-definition transcranial alternating current stimulation (HD-tACS) on subjective sleep quality and domain-specific cognitive functions in mild neurocognitive disorders due to Alzheimer's disease (NCD-AD).

Method: This study was a double blind, sham-controlled randomized clinical trial. Ninety-nine mild NCD-AD patients were randomly assigned to receive a 4-week course treatment of either 40 Hz HD-tACS, HD transcranial direct current stimulation (HD-tDCS), or sham transcranial current stimulation (HD-tCS).

Gallic acid alleviates exercise-induced muscle damage by inhibiting mitochondrial oxidative stress and ferroptosis.

Background: Skeletal muscle injury caused by excessive exercise is one of the most commonly seen clinical diseases. It is indispensable to explore drugs for treating and relieving skeletal muscle injury. Gallic acid (GA) is a polyphenolic extract that has anti-inflammatory and antioxidant biological activities.

PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [F]TZ4877 in Nonhuman Primates.

Purpose: The sphingosine-1-phosphate receptor-1 (S1PR) is involved in regulating responses to neuroimmune stimuli. There is a need for S1PR-specific radioligands with clinically suitable brain pharmcokinetic properties to complement existing radiotracers. This work evaluated a promising S1PR radiotracer, [F]TZ4877, in nonhuman primates.

Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia-reperfusion injury via Wnt/β-catenin pathway modulation.

Anchusa italica Retz. (AIR), a traditional herbal remedy, is commonly applied in managing heart and brain disorders. However, its specific function and mechanism in acute cerebral ischemia-reperfusion injury (CIRI) are not fully understood.

Loss-of-function mutations of microRNA-142-3p promote expression to induce immune evasion and hepatocellular carcinoma progression.

Background: Hepatocellular carcinoma (HCC) has been a pervasive malignancy throughout the world with elevated mortality. Efficient therapeutic targets are beneficial to treat and predict the disease. Currently, the exact molecular mechanisms leading to the progression of HCC are still unclear.

Prediction of acute kidney injury in intensive care unit patients based on interpretable machine learning.

Objective: Acute kidney injury (AKI) poses a lethal risk in intensive care unit (ICU) patients, where early detection is challenging. This study was to establish a prediction model for AKI 24 hours in advance for ICU patients and to help clinicians monitor patients at an early stage by key features.

Methods: In this study, the Medical Information Mart for Intensive Care (MIMIC) databases were used to construct a dataset of critically ill patients.

Improving Generalizability of Drug-Target Binding Prediction by Pre-trained Multi-view Molecular Representations.

Motivation: Most drugs start on their journey inside the body by binding the right target proteins. This is the reason that numerous efforts have been devoted to predicting the drug-target binding during drug development. However, the inherent diversity among molecular properties, coupled with limited training data availability, poses challenges to the accuracy and generalizability of these methods beyond their training domain.

PRMT1-mediated BRD4 arginine methylation and phosphorylation promote partial epithelial-mesenchymal transformation and renal fibrosis.

Bromodomain-containing protein 4 (BRD4) plays a vital role in fibrosis of various organs. However, the underlying mechanism of BRD4 in renal fibrosis remains unclear. To construct in vitro and in vivo models of renal fibrosis, TCMK-1 cells were subjected to TGF-β1 treatment and mice were subjected to UUO surgery and adenine induction.

Multi-dimensional analyses identify genes of high priority for pancreatic cancer research.

Pancreatic ductal adenocarcinoma (PDAC) is a drug resistant and lethal cancer. Identification of the genes that consistently show altered expression across patients' cohorts can expose effective therapeutic targets and strategies. To identify such genes, we separately analyzed five human PDAC microarray datasets.

Factors influencing preformed metal crowns and prefabricated zirconia crowns.

Backgound: Preformed metal crowns (PMCs) and zirconia crowns (ZCs) are commonly used for the treatment of primary molar caries. However, there have been no reports on factors influencing parental awareness, willingness to use these treatments, and the associated discomfort after crown placement in children.This study is the first to report factors influencing preformed crowns, providing a reference for the prevention and treatment of deciduous carious teeth.

The Effect of Low-dose Aspirin on Disease Activity in Pregnant Individuals with Inflammatory Bowel Disease.

Objectives: Low-dose aspirin (LDA) is recommended for pregnant individuals at elevated risk for hypertensive disorders of pregnancy (HDP). However, regular aspirin use may raise concerns of increased disease activity in patients with inflammatory bowel disease (IBD). We aimed to evaluate the prevalence of LDA use in pregnant IBD patients and the effect of LDA on IBD disease activity.

A Lightweight and Small Sample Bearing Fault Diagnosis Algorithm Based on Probabilistic Decoupling Knowledge Distillation and Meta-Learning.

Rolling bearings play a crucial role in industrial equipment, and their failure is highly likely to cause a series of serious consequences. Traditional deep learning-based bearing fault diagnosis algorithms rely on large amounts of training data; training and inference processes consume significant computational resources. Thus, developing a lightweight and suitable fault diagnosis algorithm for small samples is particularly crucial.

Folic Acid Prevents High-Fat Diet-Induced Postpartum Weight Retention in Rats, Which Is Associated with a Reduction in Endoplasmic Reticulum Stress-Mediated Hepatic Lipogenesis.

Background: Proactively preventing postpartum weight retention (PPWR) is one of the effective intervention strategies to reduce the occurrence of obesity in women. Population studies have shown that serum folate levels are closely related to body weight. The regulation of folic acid on lipid metabolism has been fully confirmed in both in vivo and in vitro studies.

Adaptive Control of Pressure Difference in Abrasive Flow Machining for Inner Hole with High Depth/Diameter Ratio.

To address the issue of uneven pressure distribution in the abrasive flow field within the inner hole of components with a large depth/diameter ratio, an adaptive control strategy for regulating flow field pressure difference is proposed in this paper. The strategy was based on the effects of pressure fluctuations at the abrasive flow inlet and outlet on pressure distribution patterns and pressure changes within the inner hole flow field, as derived from numerical simulations. An adaptive control fixture was also designed, enabling dynamic adjustments to the fixture gap, which significantly reduced the pressure difference in the flow field.

The Neural Palette of Heme: Altered Heme Homeostasis Underlies Defective Neurotransmission, Increased Oxidative Stress, and Disease Pathogenesis.

Heme, a complex iron-containing molecule, is traditionally recognized for its pivotal role in oxygen transport and cellular respiration. However, emerging research has illuminated its multifaceted functions in the nervous system, extending beyond its canonical roles. This review delves into the diverse roles of heme in the nervous system, highlighting its involvement in neural development, neurotransmission, and neuroprotection.

Obesity Prevalence and Associated Factors in Captive Asian Elephants () in China: A Body Condition Assessment Study.

Obesity is a prevalent health issue among captive wildlife, but the obesity status of captive Asian elephants () in China has not been systematically investigated. This study assessed obesity in 204 captive Asian elephants across 43 facilities by recording seven potentially relevant variables: sex, age, daily feed supply, proportion of high-calorie feed, outdoor enclosure area, outdoor time, and foot disorders. Body condition was evaluated using visual scoring, revealing a high prevalence of overweight and obesity, particularly in zoo-kept elephants.

Mitochondria: a crucial factor in the progression and drug resistance of colorectal cancer.

Colorectal cancer (CRC), as one of the malignant tumors with the highest incidence and mortality rates worldwide in recent years, originating primarily from the mucosal tissues of the colon or rectum, and has the potential to rapidly develop into invasive cancer. Its pathogenesis is complex, involving a multitude of factors including genetic background, lifestyle, and dietary habits. Early detection and treatment are key to improving survival rates for patients with CRC.

Identification and experimental validation of diagnostic and prognostic genes CX3CR1, PID1 and PTGDS in sepsis and ARDS using bulk and single-cell transcriptomic analysis and machine learning.

Background: Sepsis is an uncontrolled reaction to infection that causes severe organ dysfunction and is a primary cause of ARDS. Patients suffering both sepsis and ARDS have a poor prognosis and high mortality. However, the mechanisms behind their simultaneous occurrence are unclear.

Single-cell RNA sequencing highlights the unique tumor microenvironment of small cell neuroendocrine cervical carcinoma.

Small cell neuroendocrine cervical carcinoma is a highly aggressive tumor characterized by early metastasis, a high recurrence rate, and poor prognosis. This study represents the first instance of single-cell sequencing conducted on small cell neuroendocrine carcinoma of the cervix worldwide. Analysis of gene expression regulatory networks revealed that the transcription factor TFF3 drived up-regulation of ELF3.

Research progress on the synthesis, performance regulation, and applications of Prussian blue nanozymes.

Nanocatalytic medicine offers a novel solution to address the issues of low efficacy, potential side effects, and the development of drug resistance associated with traditional therapies. Therefore, developing highly efficient and durable nanozymes is of great significance for treating diseases related to oxidative stress. In recent years, prussian blue nanoparticles (PBNPs) have been demonstrated to possess multiple enzyme-like catalytic activities and are thus referred to as prussian blue nanozymes (PBNZs).

Residue depletion and withdrawal time estimation of tilmicosin in black-bone silky fowls after administration via drinking water.

In this study, residue depletion and withdrawal time estimation of tilmicosin were examined in Taihe black-bone silky fowls (TBSFs) after oral administration for three consecutive days at a dose of 75 mg/L in water. The tilmicosin concentrations in liver, kidney, muscle, and skin/fat of TBSFs collected from different time points (0.16, 1, 3, 5, 7, 9, 12, 20, 30, 40 days after last administration) were determined by UPLC-MS/MS.

Knowledge, Attitudes and Willingness of Caregivers of Preterm Infants Toward Autism: A Cross-Sectional Study.

Background: To examine the knowledge, attitudes and willingness of caregivers of preterm infants toward autism spectrum disorder (ASD).

Methods: This cross-sectional study was conducted from September to December 2022 at the Hospital and enrolled the caregivers of preterm infants. The final questionnaire, developed by the authors, included four dimensions: demographic data, knowledge (16 items), attitudes (10 items) and willingness (seven items).

Case report: Treatment of a rare primary cerebellum histiocytic sarcoma with surgery and radiotherapy.

Background: Histiocytic sarcoma originates in various tissues, including the skin, lymph nodes, gastrointestinal tract, lungs, bone marrow, and central nervous system. Primary central nervous system histiocytic sarcoma (PCNSHS) is exceptionally rare, known for its aggressive behavior and poor prognosis. This report describes a case of PCNSHS in the cerebellum treated with surgery and radiotherapy.