pH-sensitive nano-drug delivery systems dual-target endothelial cells and macrophages for enhanced treatment of atherosclerosis.

Atherosclerosis (AS) is a chronic inflammatory disease characterized by vascular endothelial dysfunction. In the early stage of the disease, endothelial cell injury induces the infiltration of inflammatory macrophages, which secrete large amounts of inflammatory factors, further aggravating endothelial cell dysfunction and exacerbating the disease. Therefore, it is promising for co-targeting endothelial cells and macrophages further regulating the inflammatory microenvironment and endothelial cell function for effective treatment.

Psychological resilience, dyadic coping, and dyadic adjustment in couples dealing with cervical cancer in Northwest China: A cross-sectional study.

Purpose: To examine the relationship between dyadic coping and dyadic adjustment in patients with cervical cancer and their spouses in northwest China, and explore the mediating role of psychological resilience in this relationship.

Methods: A cross-sectional study was conducted from June to October 2024 in two tertiary hospitals in Xinjiang Province, China; 260 patients with cervical cancer and their spouses were enrolled. Participants independently completed demographic and clinical questionnaires as well as Chinese versions of the Resilience Scale, Dyadic Coping Inventory, and Locke-Wallace Marital Adjustment Scale.

Mg-B-O Coated P2-Type Hexagonal NaMnNiO as a High-Performance Cathode for Sodium-Ion Batteries.

P2-type NaMnNiO as the cathode for sodium-ion batteries, has a relatively high theoretical specific capacity, but its unstable crystal structure and undesirable phase transitions lead to rapid capacity decay. In this work, Mg-B-O coated NaMnNiO microspheres have been synthesized via a liquid-phase method based on solvothermal synthesized NaMnNiO. The Mg-B-O coating layer significantly improves the electrochemical performance, including specific capacity, rate capability, and cycle stability.

Establishment and maturation of gut microbiota in White King pigeon squabs: role of pigeon milk.

Background: Pigeons are significant economic animals in China; however, research regarding the establishment and influencing factors of gut microbiota in squabs remains limited. Understanding how the gut microbiota develops in pigeons, particularly in relation to pigeon milk, is importance in pigeon production. This study aims to elucidate the establishment characteristics of the gut microbiota in White King pigeon squabs and explore the role of pigeon milk in this process.

Polyphenylalanine-Baicalein Nanomicelles Reduce Nerve Cell Apoptosis and Inflammation to Enhance Neuroprotection and Poststroke Rehabilitation.

Cerebral ischemic stroke, neuronal death, and inflammation bring difficulties in neuroprotection and rehabilitation. In this study, we developed and designed the ability of natural lactoferrin-polyethylene glycol-polyphenylalanine-baicalein nanomicelles (LF-PEG-PPhe-Bai) to target and reduce these pathological processes, such as neurological damage and cognitive impairment in the stages of poststroke. Nanomicelles made from biocompatible materials have improved bioavailability and targeted distribution to afflicted brain areas.

Comparative efficacy of robot-assisted therapy associated with other different interventions on upper limb rehabilitation after stroke: A protocol for a network meta-analysis.

Introduction: Post-stroke movement disorders are common, especially upper limb dysfunction, which seriously affects the physical and mental health of stroke patients. With the continuous development of intelligent technology, robot-assisted therapy has become a research hotspot in the upper limb rehabilitation of stroke patients in recent years. Many scholars have also integrated robot-assisted therapy with other interventions to improve rehabilitation outcomes.

β2-Adrenergic Receptor Agonist Clenbuterol Protects Against Acute Ischemia/Reperfusion-Induced Arrhythmia by Regulation of Akt/eNOS/NO/Cx43 Signaling Pathway.

Ventricular arrhythmias induced by ischemia/reperfusion injury limits the therapeutic effect of early reperfusion therapy for acute myocardial infarction. This study investigated the protective effects of the β2-adrenergic receptor (β2-AR) agonist clenbuterol against ischemia/reperfusion-induced arrhythmias and the underlying mechanism. Anesthetized rats were subjected to 10-min left coronary artery occlusion and 10-min reperfusion in vivo.

Antibiotic susceptibility and molecular characterization based on whole-genome sequencing of Staphylococcus aureus causing invasive infection in children and women living in Southwest China during 2018-2023.

Background: Staphylococcus aureus is one of the most common pathogens that colonizes human skin/mucous membranes, where it causes local infection that can progress to invasive infection, resulting in high morbidity and mortality worldwide. This study aimed to investigate the antibiotic susceptibility and molecular characteristics of invasive S. aureus in children and women in Southwest China from 2018 to 2023 to provide novel insights helpful in preventing and treating S.

Natural variation in MdNAC5 contributes to fruit firmness and ripening divergence in apple.

Fruit firmness is an important trait for characterizing the quality and value of apple. It also serves as an indicator of fruit maturity, as it is a complex trait regulated by multiple genes. Resequencing techniques can be employed to elucidate variations in such complex fruit traits.

Mitochondrial genome of : features, RNA editing, and insights into male sterility.

Introduction: Mitochondria are essential organelles that provide energy for plants. They are semi-autonomous, maternally inherited, and closely linked to cytoplasmic male sterility (CMS) in plants. , a widely used medicinal plant from the Caprifoliaceae family, is rich in chlorogenic acid (CGA) and its analogues, which are known for their antiviral and anticancer properties.

Moderating effects of screen time on the relationship between family functioning and negative emotions in Chinese children with cancer.

Purpose: To explore whether screen time moderates the relationship between family functioning and negative emotions in Chinese children with cancer.

Methods: Between November 2023 and May 2024, 206 children with cancer were recruited from a pediatric oncology ward at a tertiary hospital. Negative emotions, family functioning, and screen time were assessed using the Depression Anxiety Stress Scale-21, Family Adaptability and Cohesion Evaluation Scales, Second Edition, Chinese Version, and Screen Time Questionnaire, respectively.

Cellulose/covalent organic framework aerogel for efficient removal of Cr(VI): Performance and mechanism study.

Cellulose composites have exceptional qualities, particularly in removing heavy metal ions. Nevertheless, these materials' poor mechanical qualities and the restricted exposure of surface-active sites reduce the effectiveness of their removal. The removal efficiency of adsorbent materials largely depends on their macroscopic structural characteristics.

Dynamic cycles between brain states during creative storytelling.

Many theories suggest that creative thinking involves a dynamic transition between different mental states, yet empirical evidence supporting this notion remains scarce. The dual process model proposes that spontaneous thinking and deliberate thinking drive the dwell in and the transitions between different mental states during creative thinking, but there is a debate over whether the two types of thinking operate in parallel or in sequence. To address these gaps, we conducted a functional magnetic resonance imaging (fMRI) study in 41 college students during a creative storytelling task.

A mobile interactive cognitive self-assessment scale for screening cognitive impairment due to Alzheimer's disease.

Background: A mobile cognition scale for community screening in cognitive impairment with rigorous validation is in paucity. We aimed to develop a digital scale that overcame low education for community screening for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and AD.

Methods: A mobile cognitive self-assessment scale (CogSAS) was designed through the Delphi process, which is feasible for the older population with low education.

Nanoformulation of Polymyxin E Through Complex Coacervation: A Pharmacokinetic Analysis.

Polymyxin E (PME), a polymyxin antibiotic, serves as a final resort against antibiotic resistance. Nephrotoxicity is the primary concern when employing PME. To alleviate this issue, researchers have explored strategies including dosing adjustments and innovative formulations.

Metabolomic Profiling Reveals Potential Biomarkers and Prominent Features in HIV/AIDS Patients Co-Infected with SARS-CoV-2.

The underlying mechanisms and diagnostic biomarkers for the progress of COVID-19 in HIV patients have not been fully elucidated. In this study, the aim is to analyze the metabolomic profiles of HIV/AIDS patients co-infected with SARS-CoV-2 and to identify biomarkers indicative of co-infection. In this study, we conducted a retrospective cohort analysis of peripheral blood samples collected from 30 HIV/AIDS patients co-infected with SARS-CoV-2 (pc group) and 30 patients without SARS-CoV-2 (nc group).

Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice.

The visceral organ-brain axis, mediated by vagal sensory neurons, is essential for maintaining various physiological functions. Here, we investigate the impact of liver-projecting vagal sensory neurons on energy balance, hepatic steatosis, and anxiety-like behavior in mice under obesogenic conditions. A small subset of vagal sensory neurons innervate the liver and project centrally to the nucleus of the tractus solitarius, area postrema, and dorsal motor nucleus of the vagus, and peripherally to the periportal areas in the liver.

Boosting CO2 Hydrogenation by Synergistic Incorporation of Pure Slica Silicalite-1 Zeolite and CeO2 into Cu Catalysts.

Chemical conversion of CO2 is providing an opportunity to mitigate the global warming induced by the overconsumption of fossil fuel. Cu has been regarded as one of the most powerful contenders in catalyzing CO2 conversion, yet the precise manipulation of its surface state and the nearby chemical environment continues to pose a formidable challenge. In this work, we report a high-efficiency catalyst by utilizing CeO2 and pure silicon zeolite (S1) to co-activate Cu species.

Calycosin extracted from Astragali Radix reduces NETs formation to improve renal fibrosis via TLR4/NF-κB pathway.

Ethnopharmacological Relevance: Astragali Radix (A. Radix) is the dry root of the leguminous plants Astragalus membranaceus (Fisch) Beg. var.

Bacteriophage LDT325 enhances tolerance by improving antioxidant defense in tea plant [ (L.) O. Kuntze].

Bud blight caused by is a serious disease affecting tea plants and causing severe damage to production output and quality. Phages play an important role in controlling the development of bacterial diseases in plants. Previous studies have shown that the tolerance of phage-treated tea plants to bud blight was notably greater compared with that of the control group.

Microsomal glutathione transferase 1 confers cisplatin resistance of non-small cell lung cancer via interaction with arachidonate lipoxygenase 5 to repress ferroptosis.

Objectives: Cisplatin (DDP) resistance remains a primary cause of chemotherapy failure and recurrence of non-small cell lung cancer (NSCLC). Abnormal high microsomal glutathione transferase 1 (MGST1) expression has been found in DDP-resistant NSCLC cells. This study aimed to explore the function and mechanism of MGST1 in DDP resistance of NSCLC cells.

Sulfone-Embedded NIR Fluorophore with Large Stokes Shift for Monitoring Viscosity Changes during NAFLD-Induced Ferroptosis.

The accumulation of lipids in hepatocytes in nonalcoholic fatty liver disease (NAFLD) leads to an increase in reactive oxygen species and changes in the intracellular microenvironment, while ferroptosis is the result of the accumulation of iron-dependent lipid peroxidation. Studies have shown that ferroptosis plays an important role in the pathogenesis of NAFLD. Herein, we have developed a viscosity-sensitive fluorescence probe PTSO with near-infrared emission and a large Stokes shift, which were achieved by introducing the sulfone group into the dioxothiochromen-malononitrile fluorophore as an electron-withdrawing group.

Parallel Chart Writing and Resilience Impact the Narrative Competence of Medical Staff in China: A Cross-Sectional Study.

Background And Aims: Narrative competence is essential for good communication between medical staff and patients. It is a powerful instrument for the delivery of holistic healthcare. However, little research focuses on the influencing factors of narrative competence and the relationships among resilience, self-efficacy, and narrative competence.

Bibliometric analysis of metformin as an immunomodulator (2013-2024).

Background: Metformin, the frontline treatment for diabetes, has considerable potential as an immunomodulator; however, detailed bibliometric analyses on this subject are limited.

Methods: This study extracted 640 relevant articles from the Web of Science (WOS) Core Collection and conducted visual analyses using Microsoft Excel, VOSviewer, and CiteSpace.

Results: The findings showed that research on the immunomodulatory function of metformin has grown steadily since 2017, with China and the United States being the leading contributors.

Global burden, trends, and disparities in kidney cancer attributable to smoking from 1990 to 2021.

Purpose: Smoking is a well-established risk factor for kidney cancer. Analyzing the latest global spatio-temporal trends in the kidney cancer burden attributable to smoking is critical for informing effective public health policies.

Methods: Using data from the 2021 GBD database, we examined deaths, disability-adjusted life years (DALYs), and age-standardized rate (ASR) of kidney cancer attributable to smoking across global, regional, and national levels.