Curcumin suppresses metastasis, invasion, and proliferation in osteosarcoma cells by regulating the EGFR/Src signaling axis.

We explored the biological mechanisms by which curcumin (Cur) confronts osteosarcoma (OS) tumorigenesis and potential drug gene targets based on network pharmacology and in vitro cell experiments. Cur has been recognized for its significant role in combating various types of tumors. However, the intrinsic molecular mechanisms through which it affects OS remain uncharted.

F-CPI: A Multimodal Deep Learning Approach for Predicting Compound Bioactivity Changes Induced by Fluorine Substitution.

Fluorine (F) substitution is a common method of drug discovery and development. However, there are no accurate approaches available for predicting the bioactivity changes after F-substitution, as the effect of substitution on the interactions between compounds and proteins (CPI) remains a mystery. In this study, we constructed a data set with 111,168 pairs of fluorine-substituted and nonfluorine-substituted compounds.

Molecular imaging-guided diagnosis and treatment integration for brain diseases.

In practical clinical scenarios, improved diagnostic methods have been developed for the precise visualization of molecular targets using molecular imaging in brain diseases. Recently, the introduction of innovative molecular imaging modalities across both macroscopic and mesoscopic dimensions, with remarkable specificity and spatial resolution, has expanded the scope of applications beyond diagnostic testing, with the potential to guide therapeutic interventions, offering real-time feedback in the context of brain therapy. The molecular imaging-guided integration of diagnosis and treatment holds the potential to revolutionize disease management by enabling the real-time monitoring of treatment responses and therapy adjustments.

Candidatus Liberibacter asiaticus exploits cytoskeletal system of psyllid vector for circulative propagative infection.

The citrus disease Huanglongbing (HLB) in Asia and the US is caused by Candidatus Liberibacter asiaticus (CLas), which is primarily transmitted by Diaphorina citri, also known as Asian citrus psyllid in a persistent and propagative manner. However, the exact mechanisms underlying CLas circulation within D. citri remain largely unclear.

Gradient polaritonic surface with space-variant switchable light-matter interactions in 2D moiré superlattices.

Polaritons in two-dimensional (2D) materials provide unique opportunities for controlling light at nanoscales. Tailoring these polaritons via gradient polaritonic surfaces with space-variant response can enable versatile light-matter interaction platforms with advanced functionalities. However, experimental progress has been hampered by the optical losses and poor light confinement of conventionally used artificial nanostructures.

A novel all-in-one target-powered entropy-driven dynamic DNA networks to regulate the activity of CRISPR/AsCas12a for enhanced DNA detection.

Background: The non-enzyme autonomous DNA nanodevices have been developed to detect various analytes through the programmability of Watson-Crick base pairing. Nevertheless, by comparison with enzymatic biosensors, the usage of enzyme-free DNA networks to create biosensors for testing low amounts of targets is still subject to the finite number of cycles. Besides, these biosensors still require the incorporation of other amplification strategies to improve the sensitivity, which complicates the detection workflow and lacks of a uniform compatible system to respond to the target in one pot.

A post-modified lanthanide metal-organic frameworks as ratiometric luminescent sensor for the visual detection of 5-hydroxytryptamine.

5-Hydroxytryptamine (5-HT), a key neurotransmitter, is an important biomarker for carcinoid syndrome. We herein construct a ratiometric luminescent sensor by covalently coupling fluorescein 5-isothiocyanate (FITC) with lanthanide metal-organic frameworks (Ln-MOFs). In the presence of 5-HT, the emission of FITC increases while the emission of Eu decreases, accompanied by a distinct color change of emission from orange to green.

Impact of fertilization modes on the quality of japonica rice during storage under a rice-crab co-culture system.

This study investigated the impact of three different fertilization modes (traditional [FP1], one-time application of organic and inorganic fertilizer [FP2], and one-time application of inorganic fertilizer [OPT]) on the quality of japonica rice ( ) during storage under a rice-crab co-culture system. A field study was conducted, with rice samples collected every two months over a one-year storage period for quality analysis. The results showed that protein accumulated with increasing the amount of nitrogen fertilization, whereas amylose content and eating quality showed the opposite trend, further causing changes in rice quality during storage.

Association between different GLP-1 receptor agonists and acute pancreatitis: case series and real-world pharmacovigilance analysis.

Objective: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown notable advancements in managing blood sugar control. Nevertheless, there remains a gap in real-world data regarding the variation in acute pancreatitis (AP) risk among different GLP-1 RAs. Our study aimed to characterize and evaluate AP associated with different GLP-1 RAs (exenatide, lixisenatide, liraglutide, albiglutide, semaglutide, dulaglutide and tirzepatide) in a public adverse events database and to review the relevant case reports.

Construction methods and latest applications of kidney cancer organoids.

Renal cell carcinoma (RCC) is one of the deadliest malignant tumors. Despite significant advances in RCC treatment over the past decade, complete remission is rarely achieved. Consequently, there is an urgent need to explore and develop new therapies to improve the survival rates and quality of life for patients.

A low illumination target detection method based on a dynamic gradient gain allocation strategy.

Current target detection methods perform well under normal lighting conditions; however, they encounter challenges in effectively extracting features, leading to false detections and missed detections in low illumination environments. To address these issues, this study introduces an efficient target detection method for low illumination, named DimNet. This method optimizes the model through enhancements in multi-scale feature fusion, feature extraction, detection head, and loss function.

Tertiary lymphoid structures in the central nervous system.

Tertiary lymphoid structures (TLSs) frequently occur at sites of chronic inflammation. A more advanced stage of multiple sclerosis (MS) has been associated with certain TLSs. However, tumor-associated TLSs have been shown to correlate with a greater treatment response rate and a better prognosis in glioma mouse models.

Diode-pumped Kerr-lens mode-locked ytterbium-doped compositional mixed calcium aluminate laser.

A diode-pumped Kerr-lens mode-locked laser generating 25 fs pulses at 1080 nm is demonstrated with an Yb-doped compositional mixed calcium aluminate crystal. The Yb:Ca(Gd,Y)AlO laser, which operates at a repetition rate of 65.6 MHz via soft-aperture Kerr-lens mode-locking, is pumped by a spatially single-mode, fiber-coupled diode laser.

Dietary folate intake and all-cause mortality and cardiovascular mortality in American adults with non-alcoholic fatty liver disease: Data from NHANES 2003 to 2018.

Background: The relationship between dietary folate intake and prior mortality in adult patients with Non-alcoholic Fatty Liver Disease (NAFLD) has not been clearly studied. We aimed to examine the relationship between dietary folate intake and all-cause and cardiovascular (CVD) mortality in adult NAFLD patients in the US.

Methods: Using data from National Health and Nutrition Examination Survey (NHANES) 2003-2018 and associated mortality data we conducted a cohort study of US adult NAFLD subjects.

Organic Crystal with Anti-Stokes Photoluminescent Excitation and Thermally Activated Delayed Fluorescence Features.

Thermal activation process utilizes environmental thermal energy to help supplement energy for the nonspontaneous energy-consuming upconversion physical transitions with positive free energy change (ΔG>0). Reverse intersystem crossing (rISC) and hot band absorption are two kinds of thermal activation transitions. Thermally activated delayed fluorescence (TADF) materials with rISC have significantly propelled advancements in organic semiconductors.

Fabrication of clickable bamboo-sourced cellulose nanofibrils for diverse surface modifications: Hydrophobicity and fluorescence functionalities.

Surface functionalization of cellulose nanofibrils (CNF) is crucial for expanding their practical application. However, most functionalization processes are complicated and laborious. Herein, this work presents a facile surface engineering strategy to create a range of functionalized CNF via thiol-ene click reaction.

Glioma subtype prediction based on radiomics of tumor and peritumoral edema under automatic segmentation.

Comprehensive and non-invasive preoperative molecular diagnosis is important for prognostic and therapy decision-making in adult-type diffuse gliomas. We employed a deep learning method for automatic segmentation of brain gliomas directly from conventional magnetic resonance imaging (MRI) scans of the tumor core and peritumoral edema regions based on available glioma MRI data provided in the BraTS2021. Three-dimensional volumes of interest were segmented from 424 cases of glioma imaging data retrospectively obtained from two medical centers using the segmentation method and radiomic features were extracted.

A rapid, sensitive, and high-throughput pathogen detection method and application of identifying pathogens based on multiplex PCR technology combined with capillary electrophoresis.

Respiratory infections are one of the leading causes of death worldwide. Rapid and accurate detection of pathogens is crucial for timely treatment. This study established a detection method based on multiplex PCR combined with capillary electrophoresis, capable of simultaneously detecting 28 common respiratory pathogens.