Pan-cancer analysis shows that BCAP31 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types.

Background: B-cell receptor-associated protein 31 (BCAP31) is a widely expressed transmembrane protein primarily located in the endoplasmic reticulum (ER), including the ER-mitochondria associated membranes. Emerging evidence suggests that BCAP31 may play a role in cancer development and progression, although its specific effects across different cancer types remain incompletely understood.

Methods: The raw data on BCAP31 expression in tumor and adjacent non-tumor (paracancerous) samples were obtained from the Broad Institute Cancer Cell Line Encyclopedia (CCLE) and UCSC databases.

Multimodal Imaging Unveils the Impact of Nanotopography on Cellular Metabolic Activities.

Nanoscale surface topography is an effective approach in modulating cell-material interactions, significantly impacting cellular and nuclear morphologies, as well as their functionality. However, the adaptive changes in cellular metabolism induced by the mechanical and geometrical microenvironment of the nanotopography remain poorly understood. In this study, we investigated the metabolic activities in cells cultured on engineered nanopillar substrates by using a label-free multimodal optical imaging platform.

Liuweizhiji Gegen-Sangshen beverage protects against alcoholic liver disease in mice through the gut microbiota mediated SCFAs/GPR43/GLP-1 pathway.

Introduction: Alcoholic liver disease (ALD) is a pathological state of the liver caused by longterm alcohol consumption. Recent studies have shown that the modulation of the gut microbiota and its metabolic products, specifically the short-chain fatty acids (SCFAs), exert a critical role in the evolution and progression of ALD. The Liuweizhiji Gegen-Sangshen beverage (LGS), as a functional beverage in China, is derived from a traditional Chinese herbal formula and has been clinically applied for ALD treatment, demonstrating significant efficacy.

Current understanding of articular cartilage lesions in femoroacetabular impingement syndrome.

The concept of femoroacetabular impingement syndrome (FAIS) has received much attention over the past 20 years. Currently, it is believed that FAIS can lead to intra-articular pathologies such as labral tears and articular cartilage lesions, resulting in clinical symptoms and subsequent poor clinical outcomes. FAIS-related articular cartilage lesions are common but unique, and their natural course always leads to early osteoarthritis of the hip.

Constructing a green modifier by using glyoxal-urea resin and chitosan to obtain a modified soy protein adhesive with high bonding strength and excellent water resistance.

The manufacturing of soy-based adhesives with high bonding strength, excellent water resistance, and exceptional environmental performance still faces difficulties. In this work, using glyoxal-urea (GU) resin, chitosan (CS), and soy protein isolate (SPI) as the primary raw materials in order to effectively mitigate the release of free formaldehyde commonly found in traditional wood-based panels. Obtaining an adhesive with high strength, excellent water resistance, and a stable cross-linking structure of GU/CS/SPI (CS represents different mass fractions of chitosan solution).

Enhanced Thermal Safety of Hydrophobic SiO Aerogels Through Introduction of Layered Double Oxides.

This research enhances the thermal safety of hydrophobic silica aerogel (HSA) by integrating layered double oxides (LDOs). XRD and FTIR confirm that the introduction of LDOs does not affect the formation of SA. The LDO/SA composites demonstrate a low density (0.

Frequent variations and phylogenetic relationships within the genus identified by ND-FISH according to the genome-wide universal oligonucleotides chromosome probes.

Introduction: Rye ( L.) played a very important role in wheat genetic improvement and forage production worldwide. However, since rye is a kind of cross-pollinated plant, high levels of genetic heterozygosity and heterogeneity existed in the genome.

Removal of tetracycline by biochar synergistic with ferrate: Influencing mechanism on precursor biomass components.

Biochar can serve as an activator for potassium ferrate, significantly enhancing the treatment efficiency to antibiotics. However, the mechanism by which biochar activated potassium ferrate remained unclear, necessitating further investigation. Cellulose biochar (CBC) and lignin biochar (LBC) derived by two model compounds which were the highest proportion of content in biomass were adopted to be study object, to investigate the removal efficiency of tetracycline (TC) by ferrate synergetic with CBC and LBC, respectively for the first time, and thoroughly analyzed the adsorption and degradation processes within the reaction system.

Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4.

Background: Hepatocellular carcinoma (HCC) represents a major malignancy globally, characterized by high malignancy and intricate molecular mechanisms. This study aims to explore the role of the long non-coding RNA (lncRNA) lnc-EST885 in HCC development.

Methods: Cell experiments including FISH, western blot, flow cytometry and functional analysis were used to elucidate the effects of lnc-EST885 on cell proliferation, apoptosis, migration and EMT processes.

Hydrolysis of palm kernel meal fibre using a newly isolated Bacillus subtilis F6 with high mannanase activity.

Palm kernel meal (PKM) presents a challenge for non-ruminant livestock feeding due to its high fibre content predominantly in the form of mannan. Microbial fermentation offers a sustainable solution for fibre hydrolysis in lignocellulosic biomass. In this study, a Bacillus subtilis strain (F6), with high mannanase secretion capability, was isolated from the environment.

Reconfigurable Phototransistors Driven by Gate-Dependent Carrier Modulation in WSe/TaNiSe van der Waals Heterojunctions.

Reconfigurable field-effect transistors (RFETs) offer notable benefits on electronic and optoelectronic logic circuits, surpassing the integration, flexibility, and cost-efficiency of conventional complementary metal-oxide semiconductor transistors. The low on/off current ratio of these transistors remains a considerable impediment in the practical application of RFETs. To overcome these limitations, a van der Waals heterojunction (vdWH) transistor composed of WSe/TaNiSe has been proposed.

Gegen-Sangshen oral liquid and its active fractions mitigate alcoholic liver disease in mice through repairing intestinal epithelial injury and regulating gut microbiota.

Background: Liuweizhiji Gegen-Sangshen oral liquid (LGS), as a Chinese medicinal preparation, is developed from a Traditional Chinese medicinal formula consisting of six Chinese medicinal herbs, including Puerariae lobatae radix, Hoveniae semen, Imperatae rhizoma, Crataegi fructus, Mori fructus and Canarli fructus, and has been extensively utilized in the prevention and treatment of alcoholic liver disease (ALD) clinically. Previous study has demonstrated that LGS dose-dependently mitigated ALD in rat models. However, whether and how the main characteristic constituents of LGS (the flavonoid and polysaccharide fractions, LGSF and LGSP) contribute to the anti-ALD effect remains unclear.

4-Hydroxychalcone attenuates AngII-induced cardiac remodeling and dysfunction via regulating PI3K/AKT pathway.

Cardiac remodeling encompasses structural alterations such as hypertrophy, fibrosis, and dilatation, alongside numerous cellular and molecular functional aberrations, constituting a pivotal process in the advancement of heart failure (HF). 4-Hydroxychalcone (4-HCH) is a class of naturally occurring compounds with variable phenolic structures, and has demonstrated the preventive efficacy in hyperaldosteronism, inflammation and renal injury. However, the role of 4-HCH in the regulation of cardiac remodeling remains uncertain.

Associations between phthalate metabolites and body composition in children aged 8-19 years.

This study aimed to determine the relationship between individual and combined phthalate metabolites and body composition in children and adolescents using data from the 2015-2018 National Health and Nutrition Examination Survey. Single-exposure analysis indicated that most phthalate metabolites were negatively correlated with areal bone mineral density (aBMD). Quantile g-computation demonstrated a negative relationship between the mixture of phthalate metabolites and aBMD, which was confirmed by the Bayesian kernel machine regression model.

Development and validation of a radiomics-based nomogram for predicting pathological grade of upper urinary tract urothelial carcinoma.

Background: Upper urinary tract urothelial carcinoma (UTUC) is a rare and highly aggressive malignancy characterized by poor prognosis, making the accurate identification of high-grade (HG) UTUC essential for subsequent treatment strategies. This study aims to develop and validate a nomogram model using computed tomography urography (CTU) images to predict HG UTUC.

Methods: A retrospective cohort study was conducted to include patients with UTUC who underwent radical nephroureterectomy and received a CTU examination prior to surgery.

The physiological role of gamma-aminobutyric acid in relieving the effect of furfural inhibitor for improvement the production of lipid in D. intermedius Z.

In order to improve the production and quality of lipid of D. intermedius Z under the furfural stress environment, different exogenous γ-aminobutyric acid (GABA) addition strategies and their reasons for improving the fermentation performance were investigated. For this purpose, the effect of different concentrations of furfural on the production of biomass and lipid in D.

MST-G: Micro Suction Tape Gripper Climbing Robot with Active Detachment Capability.

Effective adaptive grasping capability is regarded as crucial for climbing robots. However, many dry adhesion legged climbing robots are primarily focused on mobility and load capacity to perform various climbing tasks, often overlooking their operational grasping abilities. Furthermore, flexible grippers designed for adaptive grasping are typically not capable of supporting autonomous climbing or perching motions; they must be rigidly integrated with legged climbing robots, which results in increased weight and reduced load capacity.

Metabolic nanoscopy enhanced by experimental and computational approaches.

The advances in microscopy techniques have led to new findings in biology. The recent advances in super-resolution microscopy technologies revealed precise molecular distribution. The techniques to visualize the distributions of multiple molecules in biological samples from experimental techniques to computational approaches are reviewed.

Emergency neurosurgical hybrid operating platform for acute intracranial hemorrhage (E-HOPE).

Background: Precise diagnosis and rapid treatment for acute complex intracranial hemorrhage (ICH) are crucial. The neurosurgical hybrid operating platform integrates traditional open neurosurgery operating room functionalities with endovascular therapy capabilities and is developing in the neurosurgical practice. However, its effect on the emergent complicated neurovascular cases needs pilot exploration.

Polycyclic aromatic hydrocarbons exposure in early pregnancy on child neurodevelopment.

The epidemiological evidence from studies on the impact of exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy on child neurodevelopment is inconclusive. This study aimed to assess the associations of PAHs exposure in early pregnancy and neurodevelopmental outcomes in children aged 6-12 months in a prospective cohort. In this study, we included 172 mother-child pairs with complete data in Tianjin City, China.

The Mediating Role of Resilience between Dyadic Perceived Social Support and Depression at the Older Adults with Disabilities and their Family Caregivers in China: an Actor-partner Interdependence Model Extended to Mediation.

Purpose: The goal of this study is to investigate the actor and partner effects of perceived social support and depression in older adults with disabilities and their family caregivers. Additionally, to investigate the mediating role of resilience in the actor and cross-partner effects of perceived social support on depression.

Methods: We selected 425 pairs of older adults with disabilities and their family caregiver.

Construction of Se-doped carbon encapsulated CuSe yolk-shell structure for long-life rechargeable aluminum batteries.

Rechargeable aluminum batteries (RABs) are promising alternatives to lithium-ion batteries in large-scale energy storage applications owing to the abundance of their raw materials and high safety. However, achieving high energy density and long cycling life simultaneously holds great challenges for RABs, especially for high capacity transition metal selenide (TMS)-based positive materials suffering from structural collapse and dissolution in acidic ionic liquid electrolyte. Herein, Se-doped carbon encapsulated CuSe with yolk-shell structure (YS/Se-C@CuSe) is rationally constructed to address such issues.

Two Birds With One Stone: A Novel Nanocomposite Combining Silicon Nanoparticles and Carbon-Doped Titania as the Fluorescence Probe and Visible Light Photocatalyst for Simultaneous Detection and Removal of Oxytetracycline.

The monitoring and removal of environmental pollutants are vital for the sustainable development of society. Herein, a novel nanocomposite combining silicon nanoparticles and carbon-doped titania, C-TiO/SiNPs, is designed as a fluorescence probe and visible-light photocatalyst to simultaneously monitor and degrade oxytetracycline (OTC). C-TiO/SiNPs emit blue fluorescence, which can be quenched by OTC through inner filter effect.