Divergent Photoperiodic Responses in Hypothalamic Expression and Gonadal Activity Between Offspring and Paternal Brandt's Voles.

The postnatal development of gonadal glands in seasonal breeders, particularly small rodent species, is influenced by photoperiodic patterns. However, little research has been conducted on the effects of pattern similarity and age differentiation especially in molecular features. This study compares the postnatal development of gonadal glands and the expression of hypothalamic genes related to reproductive regulation in male offspring of Brandt's voles () born under three types of changing photoperiodic patterns: increasing long photoperiod (ILP, 12 h + 3 min/day), natural increasing long photoperiods (NLPs), and decreasing short photoperiods (DSPs, 12 h - 3 min/day), as well as in their paternal voles exposed to these patterns at the same period.

CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT1 axis and mitophagy.

Background: The microenvironment of intervertebral disc degeneration (IVDD) is characterized by oxidative stress, leading to the senescence of nucleus pulposus-derived mesenchymal stem cells (NPMSCs). The purpose of this study was to investigate the competitive endogenous RNA mechanism involved in the senescence of NPMSCs induced by tert-butyl hydroperoxide (TBHP).

Methods: Bioinformatic analysis identified differentially expressed circRNAs.

Efficacy and safety of KN026 and docetaxel for HER2-positive breast cancer: a phase II clinical trial.

Background: The standard first-line treatment for human epidermal growth factor receptor 2 (HER2)-positive recurrent/metastatic breast cancer currently includes pertuzumab plus trastuzumab and docetaxel. This study aimed to evaluate the effectiveness of KN026, an anti-HER2 bispecific antibody, plus docetaxel in first-line treatment of HER2-positive recurrent/metastatic breast cancer.

Methods: This open-label, single-arm, phase II study enrolled patients with HER2-positive recurrent/metastatic breast cancer in 19 centers across China from December 30, 2019 to May 27, 2021.

Fluorescent Polymers via Coordination of -Terpyridine Ligands with Transition Metals and Their pH Response Properties.

Stimulus-responsive luminescent materials are pivotal in the field of sensing. Fluorescent transition metal complexes with a charge transfer excited state, especially terpyridine-coordinated polymers, are of particular interest due to their tunable emission. In this paper, a novel bis-terpyridine ligand was synthesized and assembled into a coordination polymer, which showed intense visible light absorption and fluorescence emission in the solid state that could be regulated by an acidic or basic pH.

Non-noble Metal Single-Molecule Photocatalysts for the Overall Photosynthesis of Hydrogen Peroxide.

Despite the great progress in molecule photocatalytic solar energy conversion, it is particularly challenging to realize a photocatalytic overall reaction in a non-noble metal complex, which represents a new paradigm for photosynthesis. In this study, a class of novel non-noble metal complexes with head-to-tail geometry were designed and readily synthesized via the coordination of triphenylamine-modified 2,2': 6',2″-terpyridine ligands with Zn. As expected, these complexes exhibited the desired through-space charge-transfer transition, generating both long-lived excited states (on the order of microseconds) and separate redox centers under visible-light irradiation.

Efficacy and Safety of Suxiao Jiuxin Pills in the Treatment of Chronic Coronary Syndrome with Intolerance to Adverse Effects of Long-acting Nitrates: A Multicenter, Randomized, Double-blind, Placebo-controlled Study.

Background: This study aims to investigate the short-term effects and safety of adjunct Suxiao Jiuxin Pills (SJPs) on conventional therapy in chronic coronary syndrome (CCS) patients who are intolerant to the adverse effects of long-acting nitrates.

Methods: This was a multicenter, randomized, double-blind, placebo-controlled trial. A total of 174 CCS participants from eight clinical study centers in China were included in the modified intention-to-treat analyses.

A study on calibration methods of noise annoyance data from listening tests.

In listening tests of noise annoyance, subjects act as "measuring instruments". Noise annoyance of different subjects induced by a same noise sample, or noise annoyance of a same subject induced by a same noise sample in different experimental groups, are different due to the varying psychological scale of subjects. To unify subjects' psychological scale and accurately determine perceived annoyance, it is necessary to investigate the optimal noise annoyance data calibration method.

GA-BP-Based Low-Noise FBG Hydroacoustic Monitoring System with Reference Sensor.

To address the issue of harsh marine background noise impacting the monitoring signal of fiber-optic hydrophones, we propose a low-noise fiber Bragg grating (FBG) hydroacoustic monitoring system with a reference sensor based on genetic algorithm backpropagation (GA-BP). Through theoretical analysis, we deduce the noise suppression steps of the GA-BP algorithm based on the reference sensor and construct train and test sets based on the data from the reference sensor and monitoring sensor at different times, optimizing the GA-BP algorithm to find the best fitting results and thereby obtaining the low-noise monitoring signal. Experimental results from the anechoic tank show that the proposed method can suppress background noise interference on effective signals and that the suppression effect improves as the background noise increases.

Metabolomics study of Shenling Baizhu Powder in the treatment of multiple organ dysfunction syndrome in the elderly (MODSE) with malnutrition.

Malnutrition is an important risk factor for multiple organ dysfunction syndrome in the elderly (MODSE) and seriously affects the occurrence, progression and prognosis of MODSE. Shenling Baizhu Power (SBP), a classic formula from traditional Chinese medicine (TCM), when integrated with enteral nutrition, has been proven to be an effective clinical strategy for treating the patients of MODSE with malnutrition. This study aimed to investigate the metabolic changes during disease occurrence and SBP treatment, and to discover potential metabolic biomarkers for the diagnosis and efficacy evaluation.

Heterometallic-Organic Cages with Customized Cavities: Constructed by Bottom-Up Step-Wise Coordination-Driven Self-Assembly.

Accurately synthesizing coordination-driven metal-organic cages with customized shape and cavity remains a great challenge for chemists. In this work, a bottom-up step-wise coordination-driven self-assembly approach was put forward. Employing this strategy, three terpyridyl heterometallic-organic truncated tetrahedral cages with different sizes and cavity were precisely synthesized.

Fatigue Behavior of the FGH96 Superalloy under High-Temperature Cyclic Loading.

Strain-controlled low-cycle fatigue (LCF) tests and stress-controlled creep-fatigue interaction (CFI) tests on the FGH96 superalloy were carried out at 550 °C to obtain the cyclic softening/hardening characteristics at different strain amplitudes and ratcheting strain characteristics under different hold time. The failure mechanism of the FGH96 superalloy under different loading conditions was analyzed through fracture observations. The results show that the FGH96 superalloy exhibits different cyclic softening/hardening characteristics at different strain amplitudes, and the introduction of the hold time at peak stress exacerbates the ratcheting strain of the FGH96 superalloy under asymmetric stress cycles.

Multi-functionalized Metallo-Supramolecular Spoked Wheels: Their Emission-Tunable Hierarchically Assembled System with Dye Molecules.

Supramolecular architectures with multiple emissive units are especially appealing due to their desired properties, such as artificial light harvesting and white-light emission. But fully achieving multi-wavelength photoluminescence in a single supramolecular architecture remains a challenge. In this paper, functionalized supramolecular architectures containing twelve metal centers and six pyrene moieties were nearly quantitatively synthesized by multi-component self-assembly and fully characterized by 1D and 2D nuclear magnetic resonance, dynamic light scattering, electrospray ionization mass spectrometry, traveling-wave ion mobility mass spectrometry, and transmission electron microscopy.

Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer.

Background: Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs) play crucial role in tumor metastasis and drug-resistance. Disheveled3 (DVL3) is involved in malignant behaviors of cancer. However, the role and potential mechanism of DVL3 remain elusive in EMT and CSLCs of colorectal cancer (CRC).

Steric Hindrance Effect as a Decisive Factor for the Self-Assembly of Metallocages.

In the past decades, many supramolecular cages with different sizes and shapes have been achieved through coordination-driven self-assembly. However, the strategy of topology adjustment by using a steric hindrance effect has not been fully developed. In this Article, we report the synthesis of ligand with rotatable arms, ligand with restricted arms, and their precisely controlled self-assembly to tetramer cage and dimer cage , respectively, under the same conditions.

A 5.3 nm giant metal-organic cage and its supramolecular gel for the formation of dye molecular ionic pairs.

A terpyridine-based supramolecular cage was successfully synthesized by the self-assembly of a hexapodal metal-organic ligand with Zn. This metallo-cage exhibited two large parallel planes on the top and bottom with diameters close to 6 nm and a face-to-face distance close to 3.5 nm, thus possessing a large cavity.

Business Strategy and Environmental Information Disclosure Quality: Empirical Evidence from Chinese Heavy Pollution Listed Firms.

Using the data of listed firms in China's A-share heavy pollution industry between 2008 and 2020, based on organizational theory, this study examines the impact of prospector-type firms and defender-type firms on environmental information disclosure quality. Empirical evidence shows that prospector-type firms reduce environmental information disclosure quality, compared with defender-type firms. After a series of robustness tests, the conclusion is still valid.

Monitoring or Colluding? Institutional Investors' Heterogeneity and Environmental Information Disclosure Behavior.

High-quality environmental information disclosure is not only an effective way for the firm to fulfill its environmental responsibility and promote green development, but also an important governance mechanism to reduce the degree of information asymmetry between the firm's management and shareholders and alleviate the agency conflict. As an important shareholder of a firm, there are two different hypotheses about the influence of institutional investors on firm decision-making and behavior: monitor and collusion. Institutional investors are not homogeneous, and there are significant differences in the impact of different types of institutional investors on firm decision-making and behavior.

TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-α pathway.

Background: Inflammation is a complex physiological and pathological process. Although many types of inflammation are well characterized, their physiological functions are largely unknown. tRNA aspartic acid methyltransferase 1 (TRDMT1) has been implicated as a stress-related protein, but its intrinsic biological role is unclear.

Psychoacoustic modelling of rotor noise.

The aviation sector is rapidly evolving with more electric propulsion systems and a variety of new technologies of vertical take-off and landing manned and unmanned aerial vehicles. Community noise impact is one of the main barriers for the wider adoption of these new vehicles. Within the framework of a perception-driven engineering approach, this paper investigates the relationship between sound quality and first order physical parameters in rotor systems to aid design.

Probiotic LF11 Protects Intestinal Epithelium Against Infection.

Enteric diseases caused by are prevalent in poultry farming. With the forbiddance of antibiotics in feedstuff industry, () preparation as antibiotic alternatives against infection has gained increasing attention recently. However, the protection modes of against infection in broilers are strain-specific.