Identification of the Microbial Transformation Products of Secoisolariciresinol Using an Untargeted Metabolomics Approach and Evaluation of the Osteogenic Activities of the Metabolites.

Secoisolariciresinol (SECO) is one of the major lignans occurring in various grains, seeds, fruits, and vegetables. The gut microbiota plays an important role in the biotransformation of dietary lignans into enterolignans, which might exhibit more potent bioactivities than the precursor lignans. This study aimed to identify, synthesize, and evaluate the microbial metabolites of SECO and to develop efficient lead compounds from the metabolites for the treatment of osteoporosis.

Efficacy and safety of percutaneous endoscopic decompression via transforaminal and interlaminar approaches for lumbar spine stenosis: Protocol for a systematic review and meta-analysis.

Background: Lumbar spinal stenosis (LSS) is a common and frequently-occurring disease in the elderly. Percutaneous endoscopic decompression (PED) has become the first choice for the treatment of LSS because of its small wound, mild pain and rapid recovery. The surgical approaches are mainly divided into percutaneous interlaminar approach and transforaminal approach.

[Preliminary investigation of acaroid mites breeding in commercial food in Hsinchu City, Taiwan Province, China].

Objective: To investigate the breeding of acaroid mites in the stored food in Taiwan Province, China.

Methods: The breeding mites from samples selected from the markets in Hsinchu City, Taiwan Province were separated under a microscope. The isolations were used for slide preparation, then observed and identified under a microscope.

[Knowledge, attitude and practice related to schistosomiasis control among rural residents in Wanjiang River region after a flood].

Objective: To investigate the status of knowledge, attitude and behavior of schistosomiasis control of rural residents in Wanjiang River region after a flood, so as to provide the reference for targeted health education.

Methods: The multistage sampling was applied to select the respondents in rural residents in Wanjiang River region, and the self-designed questionnaire was used to investigate the current situation of knowledge, attitude and behavior of schistosomiasis prevention and control of the rural residents.

Results: The total awareness rate of knowledge about the prevention and control of schistosomiasis was 47.

N-Heterocyclic carbene-catalyzed formal cross-coupling reaction of α-haloenals with thiols: organocatalytic construction of sp2 carbon-sulfur bonds.

A novel N-heterocyclic carbene (NHC)-catalyzed formal cross-coupling reaction between α-haloenals and thiols was developed. In the presence of 5 mol% NHC precursors and 1.6 equiv.

[Effect of inhibiting the expression of hSMG-1 on chemosensitivity of human non-small cell lung cancer H1299 cells].

Objective: To investigate the effect of inhibiting the expression of human suppressor of morphogenesis in genitalia-1 (hSMG-1) on chemosensitivity in human lung cancer H1299 cells.

Methods: Specialized small interference RNAs (siRNAs) of hSMG-1 were transfected into H1299 cells. The knockdown effect was evaluated by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) and immunofluorescence.