Cyclodextrin induces synergistic cryoprotection with carrageenan oligosaccharide against myofibrillar protein denaturation during fluctuated frozen storage.

High-performance saccharide-based cryoprotectants are gaining increasing attention for their application in frozen meat products. While various physiochemical and/or enzymatic approaches have been employed to enhance the cryoprotective efficacy of saccharides, potential synergistic effects between different saccharide candidates remain largely unexplored. This study, for the first time, demonstrates that the combinational use of β-cyclodextrin (CD) and carrageenan oligosaccharide (CGO) exhibit significant synergistic cryoprotective effects on surimi myofibrillar proteins (MP) during freeze-thaw cycles.

Comprehensive review of chickpea (Cicer arietinum): Nutritional significance, health benefits, techno-functionalities, and food applications.

Chickpeas (Cicer arietinum L.) are globally valued legume known for their affordability, nutritional significance, and health benefits. They are rich in protein, fiber, vitamins, and minerals such as iron, zinc, folate, and magnesium.

FusionESP: Improved Enzyme-Substrate Pair Prediction by Fusing Protein and Chemical Knowledge.

To reduce the cost of the experimental characterization of the potential substrates for enzymes, machine learning prediction models offer an alternative solution. Pretrained language models, as powerful approaches for protein and molecule representation, have been employed in the development of enzyme-substrate prediction models, achieving promising performance. In addition to continuing improvements in language models, effectively fusing encoders to handle multimodal prediction tasks is critical for further enhancing model performance by using available representation methods.

Metabolome and transcriptome analyses for explore heat stress responses and adaptation mechanisms in Rhododendron henanense subsp. lingbaoense.

In this study, we aimed to investigate the heat tolerance mechanism in Rhododendron henanense subsp. lingbaoense (Rhl). Rhl seedlings were treated at 40℃ (RLH), 32℃ (RLM), and 24℃ (RLC), and the changes in transcriptome and metabolome were compared.

Associations between vascular endothelial growth factor polymorphisms and response to 5-FU-based pharmaceutical therapy in esophageal squamous cell carcinoma: A meta-analysis.

Background And Aims: Vascular endothelial growth factor () gene polymorphisms are associated with the response to pharmaceutical therapy in many cancers. This study aimed to investigate the effects of gene polymorphisms in esophageal squamous cell carcinoma patients receiving pharmaceutical therapy.

Methods: This literature-based meta-analysis was performed with keywords related to gene polymorphisms and clinical response in esophageal squamous carcinoma patients receiving pharmaceutical therapy (including 5-FU, cisplatin, oxaliplatin, and calcium folinate).

Revealing key aroma compounds and the potential metabolic pathways in sea buckthorn berries.

To clarify the aromatic compounds of sea buckthorn and their formation pathways, the key aroma compounds in Hippophae rhamnoides subsp. sinensis were determined first. There were 21 compounds identified as the key aroma components (e.

Unveiling novel antioxidant peptides from silk fibroin proteins: An integrated in silico and in vitro study.

Antioxidant peptides exhibit significant potential in combating degenerative diseases by effectively mitigating oxidative stress. In this study, we developed a machine-learning model for screening antioxidant peptides, achieving a Matthews correlation coefficient of 0.892 ± 0.

The impact of emotional abuse on Internet addiction in Chinese children: the sequential mediation roles of emotional dysregulation and regulatory emotional self-efficacy.

Background: In China, emotional abuse and Internet addiction are increasingly prevalent among children, with significant negative effects on their development. Previous research has identified childhood emotional abuse as a major risk factor for Internet addiction in both adolescents and adults. However, the immediate impact of emotional abuse on children's Internet addiction within Chinese culture remains unclear.

Functional Properties and Potential Applications of Wheat Bran Extracts in Food and Cosmetics: A Review of Antioxidant, Enzyme-Inhibitory, and Anti-Aging Benefits.

This review examines existing studies on wheat bran extracts (WBEs) to provide an overview of their functional properties, including antioxidant and enzyme-inhibitory activities, highlighting their potential as natural alternatives for applications in both the food and cosmetic industries. Despite variations in extraction techniques, WBEs consistently demonstrated a significant presence of phenolic compounds and antioxidant activity. In the food industry, WBEs are valued for their nutritional richness, including dietary fiber, proteins, and bioactive compounds such as arabinoxylans.

pLM4CPPs: Protein Language Model-Based Predictor for Cell Penetrating Peptides.

Cell-penetrating peptides (CPPs) are short peptides capable of penetrating cell membranes, making them valuable for drug delivery and intracellular targeting. Accurate prediction of CPPs can streamline experimental validation in the lab. This study aims to assess pretrained protein language models (pLMs) for their effectiveness in representing CPPs and develop a reliable model for CPP classification.

Changes of digestive stability and potential allergenicity of high hydrostatic pressure-treated ovalbumin during in vitro digestion.

Food allergens are defined by their stability during digestion, with allergenicity largely influenced by resistance to enzymatic hydrolysis. Ovalbumin (OVA), a major egg protein, is a significant contributor to food allergies, particularly in children. Our previous work demonstrated that high hydrostatic pressure (HHP) treatment reduces OVA allergenicity by disrupting conformational epitopes and altering its structure.

Octa-Cationic Porphyrin-Functionalized Biocompatible Nanocomposite: A Promising Candidate for Enhanced Combinatorial Photodynamic and Photothermal Tumor Therapy.

The integration of photodynamic therapy (PDT) and photothermal therapy (PTT) offers a promising strategy for enhancing phototherapy efficiency. Herein, we present a dual-functional, biocompatible nanocomposite system for combination PDT/PTT therapy. The system utilizes a highly biocompatible nanoparticle assembled by an amphiphilic short peptide with the assistance of Zn as a carrier.

Inhibition of the basolateral amygdala to prelimbic cortex pathway enhances risk-taking during risky decision-making shock task in rats.

Many animal studies have explored decision-making under risk and punishment, particularly regarding potential rewards, but less focus has been placed on contexts involving net losses. Understanding decision-making under net loss conditions can shed light on the neural mechanisms involved. The basolateral amygdala to prelimbic cortex (BLA→PL) pathway is crucial for risky decision-making.

A Comparative Review: Biological Safety and Sustainability of Metal Nanomaterials Without and with Machine Learning Assistance.

In recent years, metal nanomaterials and nanoproducts have been developed intensively, and they are now widely applied across various sectors, including energy, aerospace, agriculture, industry, and biomedicine. However, nanomaterials have been identified as potentially toxic, with the toxicity of metal nanoparticles posing significant risks to both human health and the environment. Therefore, the toxicological risk assessment of metal nanomaterials is essential to identify and mitigate potential adverse effects.

A kidney protection nanoparticle based on Alpinia oxyphylla fructus polysaccharide by modulating macrophage polarization.

The use of natural polysaccharides from traditional Chinese medicine as carrier materials has great potentiality in drug delivery. Nootkatone (NKT) demonstrated good pharmacological activity in treating kidney injury, but its solubility and bioavailability are not very good which may affect the effectiveness of its therapeutic effect. Alpinia oxyphylla fructus polysaccharide (AOP), as a plant polysaccharide, has multiple pharmacological activities and may help to provide synergy for NKT.

Effects of soy flour formulation and pretreatment on the properties of gluten-free cookies: A comprehensive study from flour, dough, to baked products.

Grain-based gluten-free cookies are often nutritionally inferior owing to their low protein content. This study aimed to enhance the nutritional value of gluten-free cookies by incorporating soy flour and to investigate the effects of different types of modified soy flour on the properties of gluten-free dough and cookies. Results indicate that all types of modified soy flour significantly decreased water absorption capacity (p < 0.

Pea-Protein-Stabilized Emulsion as a High-Performance Cryoprotectant in Frozen Dough: Effects on the Storage Stability and Baking Performance.

The use of oil-in-water (O/W) emulsion has drawn increasing attention in the baking industry. Compared with some of the well-recognized functionalities, such as textural improvers and flavor carriers, its cryoprotective behavior in frozen dough has not been extensively investigated. Herein, this study reported a pea-protein (PP)-stabilized O/W emulsion with good freeze-thaw stability and evaluated its effectiveness as a high-performance dough cryoprotectant.

Antimicrobial Activities of Grape Seed, Green Tea, and Rosemary Phenolic Extracts Against Liver Abscess Causing Bacterial Pathogens in Cattle.

Liver abscesses, which occur in finishing cattle, are of significant economic concern to the feedlot industry. The causative agents include both subspecies ( and . ), (), and serotype Lubbock (S.

Enzymatic production and physicochemical and functional properties of sorghum protein isolates.

Grain sorghum has emerged as a promising source for producing alternative proteins, yet current extraction methods lack efficiency. In this study, a novel enzymatic approach using α-amylase and cellulase on sorghum materials was developed to address this challenge. Comparisons were made among the proteins isolated from dry-milled sorghum flours, wet-milled sorghum gluten meals, and sorghum dried distiller's grains (DDG).

ESMR4FBP: A pLM-based regression prediction model for specific properties of food-derived peptides optimized multiple bionic metaheuristic algorithms.

Due to the growing emphasis on food safety, peptide research is increasingly focusing on food sources. Traditional methods for determining peptide properties are expensive. While artificial intelligence (AI) models can reduce cost, existing peptide models often lack accuracy.

Research Progress on Food-Derived Bioactive Peptides: An Overview of the 3rd International Symposium on Bioactive Peptides.

Interest in food-derived bioactive peptides is on the rise. In 2023, the 3rd International Symposium on Bioactive Peptides (ISBP) was held in Niagara Falls, Canada, to provide a platform for knowledge exchange, networking, and collaboration among researchers in this field. This article aims to provide a high-level overview of the key progress and emerging trends in bioactive peptides based on the 3rd ISBP.