Hepatic arterial infusion chemotherapy enhances the efficacy of lenvatinib and PD-1 inhibitors for advanced hepatocellular carcinoma: A meta-analysis and trial sequential analysis.

Background: Hepatic arterial infusion chemotherapy (HAIC) was an effective treatment for advanced hepatocellular carcinoma (HCC), and its effectiveness in combination with targeted immunotherapy regimens was controversial. This meta-analysis was performed to evaluate the efficacy of adding HAIC to lenvatinib in combination with programmed death-1 (PD-1) inhibitors.

Methods: Literature related to the efficacy of HAIC in combination with lenvatinib plus PD-1 inhibitors in the treatment of advanced HCC was searched through PubMed, Cochrane Library, Embase, and Web of Science databases.

A Review on Branched-Chain Amino Acid Aminotransferase (BCAT) Inhibitors: Current Status, Challenges and Perspectives.

Branched-chain amino acids (BCAAs) are essential amino acids for humans and play an indispensable role in many physiological and pathological processes. Branched-chain amino acid aminotransferase (BCAT) is a key enzyme that catalyzes the metabolism of BCAAs. BCAT is upregulated in many cancers and implicated in the development and progress of some other diseases, such as metabolic and neurological diseases; and therefore, targeting BCAT might be a potential therapeutic approach for these diseases.

Portable dual-function ratio-type triple-emission molecularly imprinted fluorescence sensor for the simultaneous visual detection of hepatitis A and B viruses.

Background: Viral epidemics have long endangered human health and had dramatic impacts on environment and society. The currently known viruses and the rapid emergence of previously unknown viruses lead to an urgent need for effective virus detection strategies. It is important to develop methods that can detect multiple related viruses simultaneously in order to improve detection efficiency and to avoid treatment delays due to misdiagnoses.

Ultrahigh Energy Storage Performance in BiFeO-Based Lead-Free Ceramics via Tuning Structural Homogeneity and Domain Engineering Strategies.

Lead-free ceramic-based dielectric capacitors are critical in electronics and environmental safety. Nevertheless, developing ideal lead-free ceramics with excellent energy storage properties remains a challenging task for practical applications. Herein, the enhanced relaxation behavior and increased breakdown electric field are utilized to realize the high energy storage behavior of (0.

Size-dependent phase change in energy storage materials: Comparing the impact of solid-state wetting and of coherency stress.

Coherent phase transformations in interstitial solid solutions or intercalation compounds with a miscibility gap are of practical relevance for energy storage materials and specifically for metal hydride or lithium-ion compound nanoparticles. Different conclusions on the size-dependence of the transformation conditions are reached by modeling or theory focusing on the impact of either one (internal, solid-state-) critical-point wetting of the nanoparticle surface or coherency constraints from solute-saturated surface layers. We report a hybrid numerical approach, combining atomistic grand canonical Monte Carlo simulation with a continuum mechanics analysis of coherency stress and modeling simultaneously wetting and mechanical constraints.

Gonadotropin-releasing hormone agonist protocols for pituitary suppression in assisted reproduction.

Background: Gonadotropin-releasing hormone agonists (GnRHa) are commonly used in assisted reproduction technology (ART) cycles to prevent a luteinising hormone (LH) surge during controlled ovarian hyperstimulation (COH) prior to planned oocyte retrieval, thus optimising the chances of live birth. We compared the benefits and risks of the different GnRHa protocols used.

Objectives: To evaluate the effectiveness and safety of different GnRHa protocols used as adjuncts to COH in women undergoing ART.

AIE-active Circularly Polarized Thermally Activated Delayed Fluorescence Emitters for Stable Solution-Processed Circularly Polarized Electroluminescence.

Circularly polarized organic light-emitting diodes (CP-OLEDs) have significant promise for naked-eye 3D displays. However, most devices are fabricated using vacuum deposition technology, and development of efficient solution-processed CP-OLEDs, particularly those exhibiting low efficiency roll-off, remains a formidable challenge. This research successfully designed and synthesized two pairs of thermally activated delayed fluorescence (TADF) enantiomers through isomer engineering, namely (R/S)-N-5-TPA and (R/S)-N-4-TPA, which features fifth and fourth substitution sites of phthalimide (acceptor) by tri-phenylamine (donor), respectively.

Self-service aptamer-free molecularly imprinted paper-based sensor for high-sensitivity visual detection of influenza H5N1.

Developing low-cost self-service portable sensors to detect viruses is an important step in combating the spread of viral outbreaks. Here, we describe the development of an aptamer-free paper-based molecularly imprinted sensor for the instrument-free detection of influenza virus A (H5N1). In this sensor, Whatman paper loaded with FeO nanoparticles (WP@FeO) was prepared as a substrate upon which silicon imprinting occurred in the presence of the template virus H5N1.

Development of Composite Microbial Products for Managing Pine Wilt Disease in Infected Wood Stumps.

Wood-decay fungi, including white- and brown-decay fungi, are well known for their ability to degrade lignin and cellulose, respectively. The combined use of these fungi can increase the decomposition of woody substrates. Research has indicated that these fungi also exhibit inhibitory effects against , the causative agent of pine wilt disease (PWD).

Synergistic Effects Between Mixed Plastics and Their Impact on Pyrolysis Behavior and Pyrolysis Products.

Pyrolysis is recognized as a promising technology for waste plastics management. Although there have been many studies on pyrolysis of waste plastics, there is still a lack of in-depth research on the mechanism of synergistic effect between mixed plastics and the mechanism of product formation. In this paper, based on the pyrolysis characteristics of Polystyrene, Polyethylene, and mixed plastics (Polystyrene/Polyethylene), it is demonstrated that a synergistic effect exists in the co-pyrolysis of Polystyrene/Polyethylene and affects the pyrolysis behavior and pyrolysis products.

Cost-Reference Particle Filter-Based Method for Constructing Effective Brain Networks: Application in Optically Pumped Magnetometer Magnetoencephalography.

Optically pumped magnetometer magnetoencephalography (OPM-MEG) represents a novel method for recording neural signals in the brain, offering the potential to measure critical neuroimaging characteristics such as effective brain networks. Effective brain networks describe the causal relationships and information flow between brain regions. In constructing effective brain networks using Granger causality, the noise in the multivariate autoregressive model (MVAR) is typically assumed to follow a Gaussian distribution.

Physiological and Transcriptomic Dynamics in Mulberry: Insights into Species-Specific Responses to Midday Depression.

The midday depression of photosynthesis, a physiological phenomenon driven by environmental stress, impacts plant productivity. This study aims to elucidate the molecular and physiological responses underlying midday depression in two mulberry species, Ewu No. 1 (Ew1) and Husan No.

A Deep Evolution Policy-Based Approach for RIS-Enhanced Communication System.

This paper investigates the design of active and passive beamforming in a reconfigurable intelligent surface (RIS)-aided multi-user multiple-input single-output (MU-MISO) system with the objective of maximizing the sum rate. We propose a deep evolution policy (DEP)-based algorithm to derive the optimal beamforming strategy by generating multiple agents, each utilizing distinct deep neural networks (DNNs). Additionally, a random subspace selection (RSS) strategy is incorporated to effectively balance exploitation and exploration.

Building a teaching method for "clinical molecular biology testing technology" guided by the cultivation of thinking skills.

The knowledge of "clinical molecular biology testing technology" is complex, conceptual expressions are abstract and difficult to understand, and the student's interest in learning is low. This study aimed to evaluate the effectiveness of a cyclic teaching method based on case analysis combined with an exploratory teaching method using mind mapping as an assignment. Students from the 2019 cohort of medical laboratory technology at Hunan University of Chinese Medicine served as the control group and received conventional lecture-based teaching methods.

Chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage.

The SNF2 family chromatin remodeler HELLS has emerged as an important regulator of cell proliferation, genome stability, and several cancer pathways. Significant upregulation of HELLS has been reported in 33 human cancer types. While HELLS has been implicated in DNA damage response, its function in DNA repair is poorly understood.

GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy.

Background: Immunotherapy that targets immune checkpoints has achieved revolutionary success, but its application in solid tumors remains limited, highlighting the need for reliable enhancement of the efficacy of immunotherapy. Golgi protein 73 (GP73), a Golgi membrane protein, has been implicated in various cellular processes, including immune regulation. Recent studies suggested that GP73 may play a role in modulating the immune response in patients with cancer.

m6A RNA modification pathway: orchestrating fibrotic mechanisms across multiple organs.

Organ fibrosis, a common consequence of chronic tissue injury, presents a significant health challenge. Recent research has revealed the regulatory role of N6-methyladenosine (m6A) RNA modification in fibrosis of various organs, including the lung, liver, kidney, and heart. In this comprehensive review, we summarize the latest findings on the mechanisms and functions of m6A modification in organ fibrosis.

Composite bioreactor for synergistic Modulation of tumor microenvironment and endogenous Regulation of ROS generation to enhance chemodynamic therapy for lung cancer.

The tumor microenvironment (TME) is characterized by several key features, including hypoxia, elevated levels of hydrogen peroxide (HO), high concentrations of glutathione (GSH), and an acidic pH. Recent research has increasingly focused on harnessing or targeting these characteristics for effective cancer therapy. In this study, we developed an innovative composite bio-reactor that integrates genetically engineered bacteria with upconversion nanoparticles (UCNPs) and nano-copper manganese materials for lung cancer treatment.

Development of a robust and efficient virus-induced gene silencing system for reverse genetics in recalcitrant Camellia drupifera capsules.

Background: Virus-induced gene silencing (VIGS) is a rapid and powerful method for gene functional analysis in plants that pose challenges in stable transformation. Numerous VIGS systems based on Agrobacterium infiltration has been widely developed for tender tissues of various plant species, yet none is available for recalcitrant perennial woody plants with firmly lignified capsules, such as tea oil camellia. Therefore, there is an urgent need for an efficient, robust, and cost-effective VIGS system for recalcitrant tissues.

Epidemiological Features of Sinonasal Adenocarcinoma and Prognostic Nomogram: A Study Based on the SEER Database.

Objective: Our study aimed to update demographic profiles of sinonasal adenocarcinoma (SNAC) between 2000 and 2020, identify independent prognostic risk factors, and devise a predictive nomogram for overall survival (OS).

Methods: Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, cases of SNAC from 2000 to 2020 were analyzed for incidence trends. Univariate and multivariate Cox regression models helped pinpoint factors impacting patient survival.

NK Cell Exosomes Alleviate PD-L1 Expression and Facilitate Tumor Immunity by Repressing PI3K-AKT-mTOR Signaling.

Background: Liver cancer (LC) is a deadly malignancy with limited therapeutic options in recent years. Natural killer cell-derived exosomes (NK-exo), as an important bridge of information transmission between cells, also have a certain killing effect on tumor cells. On this basis, this study investigated the specific regulatory mechanism of NK-exo on LC cells.