TFAP2A Activates ADAM8 to Promote Lung Adenocarcinoma Angiogenesis Through the JAK/STAT Signaling Pathway.

As the most prevalent subtype of lung cancer, lung adenocarcinoma (LUAD) is closely associated with angiogenesis, which is fundamental to its progression. ADAM8 (A disintegrin and metalloproteinase 8) is an enzyme associated with tumor invasion, while its implications in LUAD angiogenesis are a field that awaits exploration. A thorough investigation into the impacts of ADAM8 on LUAD angiogenesis could contribute to the development of therapeutic drugs for LUAD.

Reversible Isomerization of Stiff-Stilbene by an Oriented External Electric Field.

Understanding and effectively controlling molecular conformational changes are essential for developing responsive and dynamic molecular systems. Here, we report that an oriented external electric field (OEEF) is an effective catalyst for the cis-trans isomerization of stiff-stilbene, a key component of overcrowded alkene-based rotary motors. This reversible isomerization occurs under ambient conditions, is free from side reactions, and has been verified using ultraperformance liquid chromatography and UV-vis absorption spectroscopy.

Exploring the interdependencies of ecosystem services and social-ecological factors on the Loess Plateau through network analysis.

Ecosystem services arise from and are shaped by interactions within social-ecological systems. While network approaches hold promise for conceptualizing and managing ecosystem services, their practical application remains underexplored. This study introduces a novel application of the partial correlation network approach to ecosystem service research, using China's Loess Plateau as a case study to analyze ecosystem services and social-ecological factors within a network framework.

Unveiling the Role of SLC6A17 in Lung Adenocarcinoma: Prognosis, Pathways, and Therapeutic Implications.

Background: The role of solute carrier family 6 member 17 (SLC6A17) in lung adenocarcinoma (LUAD) is unclear.

Objectives: To address this gap in knowledge, we employed bioinformatics analysis and experimental validation.

Methods: This research aimed to scrutinize the expression patterns of the SLC6A17 gene across a spectrum of cancers and specifically within LUAD, utilizing data extracted from The Cancer Genome Atlas (TCGA).

Dual-frequency ultrasonic-assisted enzymolysis for synthesis of microstructure regulated biomass-derived porous carbon for high-performance supercapacitors.

Biomass-derived porous carbon (PC) has emerged as a promising candidate for electrode materials in energy storage applications, effective pretreatment of the precursor is a key strategy for enhancing the electrochemical performance of PC. However, challenges remain in achieving this goal through environmentally friendly, simple, and efficient methods. In this paper, a dual-frequency ultrasonic-assisted enzymolysis strategy combined with carbonization-activation method was proposed to prepare high-performance garlic peel-derived PC (DUGPC) for supercapacitors.

Constructing two bifunctional tooth-targeting antimicrobial peptides for caries management: an in vitro study.

Objectives: Caries is a significant public health challenge. Herein, novel tooth-targeting antimicrobial peptides (HABPs@AMPs) were developed by combining the antimicrobial peptide DJK-5 with hydroxyapatite (HA) binding peptides, providing a potential new strategy for caries management.

Materials And Methods: The minimal inhibitory concentration (MIC) and minimal biofilm inhibitory concentration (MBIC) values of HABPs@AMPs were determined via micro-broth dilution and crystal violet staining.

Effects of transglutaminase on the gelation properties and digestibility of pea protein isolate with resonance acoustic mixing pretreatment.

Our previous research confirmed that resonance acoustic mixing (RAM) pretreatment effectively improved the emulsification and water retention of commercial pea protein isolate (PPI), but significantly reduced its gel performance. This study aimed to investigate the effect of transglutaminase (TGase, 0.1 %, 0.

Establishment and clinical application of a prognostic index for inflammatory status in triple-negative breast cancer patients undergoing neoadjuvant therapy using machine learning.

Objective: This study aims to establish a new prognostic index using machine learning models to predict the clinical outcomes of triple-negative breast cancer (TNBC) patients receiving neoadjuvant therapy.

Methods: In this study, we collected data from the electronic medical records system of Harbin Medical University Cancer Hospital to establish a training set of 501 breast cancer patients who received neoadjuvant therapy from January 2017 to December 2021. Additionally, we collected data from Harbin Medical University Affiliated Cancer Hospital, Harbin Medical University Affiliated Second Hospital, and Harbin Medical University Affiliated Sixth Hospital to establish a validation set of 1533 patients during the same period.

N-doped porous carbon derived from different lignocellulosic biomass models for high-performance supercapacitors: the role of lignin, cellulose and hemicellulose.

Biomass-derived porous carbon (PC) has been widely studied in the field of supercapacitors due to its low cost, sustainability and developed pore structure, but how to screen the precursors of high-performance PC is still a major difficulty. Herein, six lignocellulosic biomass models based on different compositions were innovatively constructed and prepared into high-performance PC by a synergistic activation-doping strategy. The results show that the synergistic activation-doping strategy has a certain universality for biomass models.

A processable and recyclable gelatin/carboxymethyl chitosan hydrogel electrolyte for high performance flexible zinc-ion batteries.

Hydrogels are currently under extensive research as flexible quasi-solid electrolytes for zinc-ion batteries. However, the non-degradability and non-recyclability of hydrogel electrolytes pose significant issues, leading to resource wastage and plastic pollution. Moreover, the increasing needs of hydrogel electrolyte with various shapes to meet individual requirements of next-generation flexible battery raise significant challenges.

Catalytic Intermolecular Asymmetric [2π + 2σ] Cycloadditions of Bicyclo[1.1.0]butanes: Practical Synthesis of Enantioenriched Highly Substituted Bicyclo[2.1.1]hexanes.

The high percentage of sp-hybridized carbons and the presence of chiral carbon centers could contribute to increased molecular complexity, enhancing the likelihood of clinical success of drug candidates. Three-dimensional (3D) bridged motifs have recently garnered significant interest in medicinal chemistry. Bicyclo[2.

Phenolic acid-containing compounds enhanced Fe/peroxides processes for efficient removal of sulfamethoxazole in surface waters.

Sulfamethoxazole (SMX) in surface waters has raised widespread concerns due to its potential environmental and biological hazards. In this study, the performance, mechanism, and environmental application of phenolic acid-containing compounds (PACCs) enhanced Fe/peroxides processes for SMX degradation were investigated. PACCs with two Ar-OH groups exhibited the lowest toxicity and the best enhancement performance (65%-66% of PDS, 47%-58% of PMS and 61%-63% of HO), which were attributed to the excellent chelating and reducing ability towards Fe.

Strong adsorption FeNC catalytic cathode for 50,000 cycles aqueous zinc-iodine batteries.

Aqueous zinc-iodine batteries have garnered increasing attention due to their low cost and high safety. However, their practical application is impeded by sluggish iodine redox reaction kinetics and the "shuttle effect" of polyiodides, which result in poor rate performance and limited cycled life. Here, we developed N-doped porous carbon fiber derived from Prussian blue and polyacrylonitrile (PAN) as a self-supporting cathode material for zinc-iodine batteries.

[Source Profiles of VOCs for Different Types of Industrial Boilers in Sichuan, China].

Seven different types of industrial boilers in Sichuan Province were selected to determine the VOC emission components and the source profiles of VOCs containing 115 components were established using Teflon sampling and GC-MS/FID analysis. The ozone formation potential （OFP） and emission factors of VOCs from different types of industrial boilers were analyzed. The results showed that the VOC components emitted from different types of industrial boilers were different.

Predicting plateau atmospheric ozone concentrations by a machine learning approach: A case study of a typical city on the southwestern plateau of China.

Atmospheric ozone (O) has been placed on the priority control pollutant list in China's 14th Five-Year Plan. Due to their unique meteorological conditions, plateau regions contain high concentrations of atmospheric O. However, traditional experimental methods for determining O concentrations using automatic monitoring stations cannot predict O trends.

Development of the TP53 mutation associated hypopharyngeal squamous cell carcinoma prognostic model through bulk multi-omics sequencing and single-cell sequencing.

Objective: The aim of this study was to construct a prognostic model based on the TP53 mutation to calculate prognostic risk scores of patients with HPSCC.

Methods: TP53 mutation and transcriptome data were downloaded from the TCGA databases. Gene expression data from GSE65858, GSE41613, GSE3292, GSE31056, GSE39366, and GSE227156 datasets were downloaded from the GEO database.

Risk prediction model for in-stent restenosis following PCI: a systematic review.

Introduction: The morbidity and mortality rates of coronary heart disease are significant, with PCI being the primary treatment. The high incidence of ISR following PCI poses a challenge to its effectiveness. Currently, there are numerous studies on ISR risk prediction models after PCI, but the quality varies and there is still a lack of systematic evaluation and analysis.

A self-powered and self-monitoring ultra-low frequency wave energy harvester for smart ocean ranches.

The ocean ranch environment contains ultra-low-frequency wave energy that can be utilized for powering low-power equipment. Therefore, this article proposes a smart ocean ranch self-powered and self-monitoring system (SOR-SSS) which consists of several key components: a mass pendulum ball (MPB), a commutation wheel system (CWS), an electromagnetic energy harvesting unit (EEHU), and four piezoelectric energy harvesting units (PEHU). Through six-degree-of-freedom vibration test bench experiments, the SOR-SSS achieved a maximum output power of 17.

Neoadjuvant Immunotherapy Alone for Patients With Locally Advanced and Resectable Metastatic Colorectal Cancer of dMMR/MSI-H Status.

Background: The use of programmed death-1 blockade has a significant therapeutic effect in patients with mismatch repair-deficient/microsatellite instability-high metastatic colorectal cancer. However, data on preoperative single-agent programmed death-1 blockade are rare.

Objective: This study aims to evaluate the effectiveness and safety of preoperative programmed death-1 blockade as a conversion strategy in patients with locally advanced and resectable metastatic mismatch repair-deficient/microsatellite instability-high colorectal cancer.

Photochemical activity of water-soluble organic compounds in motor vehicle exhaust particulate matter.

Particulate matter from motor vehicle exhaust is a type of important atmospheric particulates, which can absorb sunlight affecting its photochemical behavior. However, the photochemical activity of water-soluble organic compounds (WSOC) in motor vehicle exhaust particulate matter has not been explored. Here, we applied WSOC in particulate matter from motor vehicle exhaust to investigate the photogenerating ability of its reactive oxygen species (ROS) and its effect based on model phenol photodegradation with the comparison between WSOC in diesel particulate matter and in gasoline particulate matter.

Correlations among parameters of pentacam, iTrace, and LOCS III in assessing lens opacity.

Objectives: To investigate the diagnostic value of iTrace visual function analyzer, Pentacam 3D anterior segment analysis system and Lens Opacities Classification System III (LOCS III) in assessing lens opacity in patients with age-related cataract (ARC).

Methods: A total of 129 patients with ARC admitted to Anonymized from May 2019 to April 2021 were selected as the research objects. The degree of lens opacity was evaluated by LOCS III classification, iTrace and anterior segment analysis.