Healthcare-seeking delays and associated factors among immigrant patients with acute ischaemic stroke in Shenzhen: a retrospective observational study.

Objective: To examine healthcare-seeking delays among immigrant patients with acute ischaemic stroke (AIS), identifying key factors contributing to these delays and proposing evidence-based interventions for policy formulation and research.

Design: A retrospective observational study analysing healthcare-seeking behaviours and delay times among immigrant patients with AIS treated at the Department of Neurology, Longhua District People's Hospital, Shenzhen, from December 2021 to October 2023. The study included 1356 patients with AIS, all part of the immigrant population as defined by Shenzhen Statistical Yearbook criteria.

Efficacy of Hongjing I granule, an herbal medicine, in patients with mild to moderate erectile dysfunction in a randomized controlled trial.

Background: HJIG is a potential treatment for erectile dysfunction (ED) that has been used in China for over 20 years. We conducted a multi-center, double-blind, randomized, placebo-controlled trial to evaluate the effectiveness and safety of the Chinese Herbal Medicine, Hongjing I granule (HJIG), in patients with mild to moderate erectile dysfunction (ED).

Methods: This study is structured as a randomized, double-blind, placebo-controlled trial, executed across multiple centers.

Labeling and isolating cell specific neuronal mitochondria and their functional analysis in mice post stroke.

Dendritic and axonal plasticity, which mediates neurobiological recovery after a stroke, critically depends on the mitochondrial function of neurons. To investigate, in vivo, neuronal mitochondrial function at the stroke recovery stage, we employed Mito-tag mice combined with cerebral cortical infection of AAV9 produced from plasmids carrying Cre-recombinase controlled by two neuronal promoters, synapsin-I (SYN1) and calmodulin-kinase IIa to induce expression of a hemagglutinin (HA)-tagged enhanced green fluorescence protein (EGFP) that localizes to mitochondrial outer membranes of SYN1 positive (SYN) and CaMKIIa positive (CaMKIIa) neurons. These mice were then subjected to permanent middle cerebral artery occlusion (MCAO) and sacrificed 14 days post stroke.

Natural potential difference induced functional optimization mechanism for Zn-based multimetal bone implants.

Zn-based biodegradable metals (BMs) are regarded as revolutionary biomaterials for bone implants. However, their clinical application is limited by insufficient mechanical properties, delayed degradation, and overdose-induced Zn toxicity. Herein, innovative multi-material additive manufacturing (MMAM) is deployed to construct a Zn/titanium (Ti) hetero-structured composite.

Automatic Detection and Classification of Natural Weld Defects Using Alternating Magneto-Optical Imaging and ResNet50.

It is difficult to detect and identify natural defects in welded components. To solve this problem, according to the Faraday magneto-optical (MO) effect, a nondestructive testing system for MO imaging, excited by an alternating magnetic field, is established. For the acquired MO images of crack, pit, lack of penetration, gas pore, and no defect, Gaussian filtering, bilateral filtering, and median filtering are applied for image preprocessing.

Targeting mechanistic target of rapamycin complex 2 attenuates immunopathology in Systemic Lupus Erythematosus.

Objective: We aim to explore the role of mechanistic target of rapamycin complex (mTORC) 2 in systemic lupus erythematosus (SLE) development, the in vivo regulation of mTORC2 by type I interferon (IFN) signaling in autoimmunity, and to use mTORC2 targeting therapy to ameliorate lupus-like symptoms in an in vivo lupus mouse model and an in vitro coculture model using human PBMCs.

Method: We first induced lupus-like disease in T cell specific Rictor, a key component of mTORC2, deficient mice by topical application of imiquimod (IMQ) and monitored disease development. Next, we investigated the changes of mTORC2 signaling and immunological phenotypes in type I IFNAR deficient Lpr mice.

Application of task-autonomous dental robot for lateral window preparation in the maxillary sinus.

The study aimed to investigate the feasibility and accuracy of task-autonomous dental robots for lateral window preparation in the maxillary sinus, as well as to propose 3 indexes for assessing the accuracy of lateral window preparation. Twenty 1:1 resin maxilla models were fabricated, all of which underwent preoperative CBCT and utilized the data to design 40 lateral windows. A task-autonomous dental robot was used to autonomously perform the preparation of 20 lateral windows according to the design under supervision, while another 20 lateral windows were prepared with freehand as control.

Boosted Meat Flavor by the Metabolomic Effects of Nile Tilapia Dietary Inclusion of Larval Meal.

Background: larval meal (ZLM) is a high-quality feed supplement with potential activities that can improve fish growth performance and promote meat quality. However, there have been limited recent studies investigating the metabolic effects of ZLM. Therefore, this study aims to uncover the metabolomic mechanism through which ZLM improves tilapia meat flavor using metabolomic strategies.

Accelerated Hydrothermal Aging and Degradation Mechanism of PE100 Butt-Fusion Welded Joint.

High-density polyethylene (HDPE) pipelines are extensively utilized in energy transportation in the ocean. However, long-term exposure to water can alter the performance of HDPE, potentially leading to pipeline accidents. This study focuses on simulating the aging characteristics of PE100 polyethylene pipeline butt-fusion welded joints (B-FWJs) in water using hydrothermal accelerated aging experiments at various temperature gradients.

MAZ regulates ferroptosis, apoptosis and differentiation of oligodendrocyte precursor cells.

Oligodendrocyte precursor cells (OPCs) respond rapidly to demyelination injury. However, the rescuing effects may be hindered by cell death of OPCs, leading to incomplete remyelination. This study aimed to explore the expression of MYC-associated zinc finger protein (MAZ) in demyelinated mice and the effects of MAZ on cell death form and differentiation of OPCs.

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.

Germinal center (GC) formation, which is an integrant part of humoral immunity, involves energy-consuming metabolic reprogramming. Rag-GTPases are known to signal amino acid availability to cellular pathways that regulate nutrient distribution such as the mechanistic target of rapamycin complex 1 (mTORC1) pathway and the transcription factors TFEB and TFE3. However, the contribution of these factors to humoral immunity remains undefined.

Optimal human respiratory simulation for exhaled gas based on CFD method.

Human breathing is crucial for studying indoor environments and human health. Computational Fluid Dynamics (CFD) is a key tool for simulating human respiration. To enhance the accuracy of CFD simulations and reduce computation time, a new simulation strategy for human respiration is proposed in this paper.

Research on Target Image Classification in Low-Light Night Vision.

In extremely dark conditions, low-light imaging may offer spectators a rich visual experience, which is important for both military and civic applications. However, the images taken in ultra-micro light environments usually have inherent defects such as extremely low brightness and contrast, a high noise level, and serious loss of scene details and colors, which leads to great challenges in the research of low-light image and object detection and classification. The low-light night vision image used as the study object in this work has an excessively dim overall picture and very little information about the screen's features.

DyGraphformer: Transformer combining dynamic spatio-temporal graph network for multivariate time series forecasting.

Transformer-based models demonstrate tremendous potential for Multivariate Time Series (MTS) forecasting due to their ability to capture long-term temporal dependencies by using the self-attention mechanism. However, effectively modeling the spatial correlation cross series for MTS is a challenge for Transformer. Although Graph Neural Networks (GNN) are competent for modeling spatial dependencies across series, existing methods are based on the assumption of static relationships between variables, which do not align with the time-varying spatial dependencies in real-world series.

Insights into ubiquitinome dynamics in the host‒pathogen interplay during Francisella novicida infection.

Ubiquitination functions as an important posttranslational modification for orchestrating inflammatory immune responses and cell death during pathogenic infection. The ubiquitination machinery is a major target hijacked by pathogenic bacteria to promote their survival and proliferation. Type I interferon (IFN-I) plays detrimental roles in host defense against Francisella novicida (F.

Framework for Nursing Quality Assessment in Tracheotomy Dysphagia Following Craniocerebral Trauma Using the Structure-Process-Outcome Model.

Aim: This study aimed to establish a comprehensive set of nursing-sensitive quality indicators (NSQIs) for patients with dysphagia following tracheotomy due to acquired brain injury (ABI), based on the 'structure-process-outcome' model.

Design: A Delphi survey.

Methods: The research utilised a mixed-methods approach, including systematic literature reviews, qualitative interviews and two rounds of Delphi expert consultations.

Mitigating Social Isolation Among Peritoneal Dialysis Patients: The Impact of Educational Level, Physical Activity, and Familial Support.

Objective: This study investigates the prevalence and determinants of social isolation in peritoneal dialysis (PD) patients, focusing on the influence of environmental systems and individual behaviors on their social well-being.

Methods: We conducted a cross-sectional study from December 2023 to February 2024 at Shenzhen Traditional Chinese Medicine Hospital. A total of 259 PD patients were enrolled using a consecutive sampling method.

Digital Dental Biometrics for Human Identification Based on Automated 3D Point Cloud Feature Extraction and Registration.

Background: Intraoral scans (IOS) provide precise 3D data of dental crowns and gingival structures. This paper explores an application of IOS in human identification.

Methods: We propose a dental biometrics framework for human identification using 3D dental point clouds based on machine learning-related algorithms, encompassing three stages: data preprocessing, feature extraction, and registration-based identification.

Flexible AIE/PCM composite fiber with biosensing of alcohol, fluorescent anti-counterfeiting and body thermal management functions.

Alcohol sensing plays a critical role in medical detection and personal health management. AIE materials with high sensitivity, selectivity and fast response have been widely used in biosensing, but their application in the field of alcohol sensing still needs further research and development. Furthermore, developing flexible phase change materials (PCMs) is significant for the research of human-body thermal management.