Publications by authors named "Li Yan-Chun"

This study aimed to analyze the impact of single nucleotide polymorphism (SNP) of (encoding adenylate cyclase 3) on the outcome of high-intensity interval training (HIIT) on body composition and screen genetic markers sensitive to HIIT in Chinese Han youth. A total of 237 non-regular exercise Han college students were recruited in a 12-week HIIT program, attending sessions 3 times a week. Before and after the HIIT program, their body composition was measured.

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In this study, diglycidylether of bisphenol A (DGEBA)/expanded graphite (EG)/copper (Cu) powder composites with high thermal conductivity were prepared for use as thermal interface materials. To construct an excellent thermally conductive network, the Cu surface was modified using the ionic liquid 1-ethyl-3-methyl imidazolium dicyanamide. In addition, the effect of the Cu content on the thermal conductivity, thermal stability, flexural properties, impact strength, and morphologies of the DGEBA/EG/Cu composites was investigated.

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Species of the genus (Thelephorales, Thelephoraceae) are ectomycorrhizal symbionts of coniferous and broad-leaved plants, and some of them are well-known edible mushrooms, making it an exceptionally important group ecologically and economically. However, the diversity of the species from China has not been fully elucidated. In this study, we conducted a phylogenetic analysis based on the internal transcribed spacer (ITS) regions, using Maximum Likelihood and Bayesian analyses, along with morphological observations of this genus.

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The application of liquid crystal technology typically relies on the precise control of molecular orientation at a surface or interface. This control can be achieved through a combination of morphological and chemical methods. Consequently, variations in constrained boundary flexibility can result in a diverse range of phase behaviors.

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In this study, to improve the electrical properties and impact strength of phenolic formaldehyde (PF) resin, PF-based composites were prepared by mixing graphene and the ionic liquid 3-decyl-bis(1-vinyl-1-imidazole-3-ium-bromide) (C[VImBr]) via hot blending and compression-curing processes. The graphene surface was modified using a silane coupling agent. The synergistic effect of graphene and C[VImBr] on the electrical properties, electromagnetic shielding efficiency, thermal stability, impact strength, and morphology of PF/graphene and PF/graphene/C[VImBr] composites was then investigated.

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We demonstrated direct conversion of benzene into pyridine and aniline, assisted through exact mass measurements (/ 80.0494, 93.0574, and 94.

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Recent advancements in ultra-sensitive detection, particularly the Aggregation Induced Emission (AIE) materials, have demonstrated a promising detection method due to their low cost, real-time detection, and simplicity of operation. Here, coumarin functionalized pillar[5]arene (P5C) and bis-bromohexyl pillar[5]arene (DP5) were successfully combined to create a linear AIE supramolecular pseudorotaxane polymer (PCDP-G). The use of PCDP-G as a supramolecular AIE polymer material for recyclable ultra-sensitive Fe and F detection is an interesting application of the materials.

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Background: High serum uric acid (SUA) levels increase the risk of overall cancer morbidity and mortality, particularly for digestive malignancies. Nevertheless, the correlation between SUA level and clinical outcomes of the postoperative patients with colorectal cancer (CRC) treated by chemotherapy is unclear. This study aimed at exploring the relationship between baseline SUA level and progression-free survival (PFS), disease control rate (DCR), and safety in postoperative CRC patients receiving chemotherapy.

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Article Synopsis
  • Gut stem cells help keep our intestines healthy, but when a specific protein called Mettl14 was removed from mouse gut cells, it caused serious problems like inflammation and stunted growth.
  • This loss of Mettl14 made some important stem cells die off, leading to even more issues in the gut.
  • Adding back a protein called GSDMC helped save the gut cells and prevent the mice from dying too soon, showing how important these proteins are for healthy intestines.
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Here, we report on the abundant formation of phenol and molecular hydrogen when benzene vapor was exposed to gas plasma generated by +5.5 kV corona discharge of water vapor in argon in the absence of oxygen. Systematic analysis using a series of isotopic standards (-benzene, DO, and HO) and benzene derivatives (mono-, di-, trichlorobenzene, and ,-dimethylaniline) indicated that the formation of phenol occurred through the reaction between neutral benzene and the radical cation of water dimer, (HO).

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  • Macrophages are important cells in our body's immune system that help fight diseases and infections.
  • Researchers often use a special method to remove these cells from mice to study how they work.
  • This study explains a new way to take out macrophages and then replace them with modified ones to help understand what happens during infections like sepsis.
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Social memory is the ability to discriminate familiar conspecific from the unknown ones. Prefrontal neurons are essentially required for social memory, but the mechanism associated with this regulation remains unknown. It is also unclear to what extent the neuronal representations of social memory formation and retrieval events overlap in the prefrontal cortex (PFC) and which event drives social memory strength.

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Background: Currently, there are few studies on the correlation between platelet counts (PLT), plateletcrit (PCT), and platelet-to-lymphocyte ratio (PLR) in small cell lung carcinoma (SCLC) with and without pleural effusion. This study is to investigate their likely correlation and to evaluate the potential diagnostic or prognostic applications of these platelet parameters.

Methods: A total of 218 each of patients with primary SCLC and healthy controls were included.

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is one of the most important groups of boletes. Most species in this genus are ectomycorrhizal symbionts of various plants, and some of them are well-known edible mushrooms, making it an exceptionally important group ecologically and economically. The scientific problems related to this genus include that the identification of species in this genus from China need to be verified, especially those referring to European or North American species, and knowledge of the phylogeny and diversity of the species from China is limited.

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  • Idiopathic pulmonary fibrosis (IPF) is a serious lung disease that causes breathing problems and can't be reversed.
  • In a study with mice, researchers found that a type of vitamin D called paricalcitol helps protect against lung damage caused by a harmful substance called bleomycin.
  • The study showed that vitamin D helps reduce harmful proteins in the lungs and prevents weight loss, suggesting that it may be important for people with lung diseases.
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species with cyanescent oxidation reactions were investigated, based on morphology and phylogenetic analysis of DNA sequences from the nuclear ribosomal large subunit (nrLSU), the nuclear ribosomal internal transcribed spacer (ITS) and the mitochondrial adenosine triphosphate ATP synthase subunit 6 (). Three species, including two new species, namely and and one previously-described species, namely , are revealed from China. Collections formerly reported from China as "" are either or .

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  • - The study investigates the prevalence and characteristics of Mycoplasma pneumonia (MP) septicemia in children hospitalized for MP pneumonia, finding a moderate occurrence rate.
  • - Researchers analyzed 61 children with MP pneumonia and 30 healthy controls using qPCR tests on blood samples, with 50.8% of infected children testing positive for MP.
  • - Results suggest that while MP septicemia is present in affected children, the clinical usefulness of detecting MP in blood for treatment decisions may be limited.
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Background: Liver cancer is one of the most common malignant tumors, and ranks as the fourth leading cause of cancer death worldwide. Microvascular invasion (MVI) is considered one of the most important factors for recurrence and poor prognosis of liver cancer. Thus, accurately identifying MVI before surgery is of great importance in making treatment strategies and predicting the prognosis of patients with hepatocellular carcinoma (HCC).

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Background: Our previous studies showed that vitamin D receptor (VDR) depletion promotes lipopolysaccharide (LPS)-induced acute kidney injury (AKI) in mice, and renal VDR is down-regulated in AKI, but the mechanism of VDR down-regulation is unclear.

Methods: Nutritional vitamin D deficiency was induced by feeding mice a vitamin D-deficient (VD-D) diet. Mice were injected intraperitoneally with LPS (20 mg/kg) to establish LPS-induced AKI.

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  • The study explores the link between vitamin D deficiency and the renin-angiotensin system (RAS) in the context of inflammatory bowel disease (IBD) using a mouse model.
  • Mice on a vitamin D-deficient diet showed worse colitis symptoms and more inflammation compared to those with sufficient vitamin D, as indicated by increased cytokines and RAS activation.
  • Treatment with an angiotensin II receptor blocker, losartan, reduced the severity of colitis in vitamin D-deficient mice, suggesting that RAS plays a role in the inflammation process related to vitamin D levels.
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Because ADAM17 promotes colonic tumorigenesis, we investigated potential miRNAs regulating ADAM17; and examined effects of diet and tumorigenesis on these miRNAs. We also examined pre-miRNA processing and tumour suppressor roles of several of these miRNAs in experimental colon cancer. Using TargetScan, miR-145, miR-148a, and miR-152 were predicted to regulate ADAM17.

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Bacterial infection triggers a cytokine storm that needs to be resolved to maintain the host's wellbeing. Here, we report that ablation of mA methyltransferase subunit METTL14 in myeloid cells exacerbates macrophage responses to acute bacterial infection in mice, leading to high mortality due to sustained production of pro-inflammatory cytokines. METTL14 depletion blunts Socs1 mA methylation and reduces YTHDF1 binding to the mA sites, which diminishes SOCS1 induction leading to the overactivation of TLR4/NF-κB signaling.

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Background: The medial prefrontal cortex (mPFC) is essential for social behaviors, yet whether and how it encodes social memory remains unclear.

Methods: We combined whole-cell patch recording, morphological analysis, optogenetic/chemogenetic manipulation, and the TRAP (targeted recombination in active populations) transgenic mouse tool to study the social-associated neural populations in the mPFC.

Results: Fos-TRAPed prefrontal social-associated neurons are excitatory pyramidal neurons with relatively small soma sizes and thin-tufted apical dendrite.

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  • Obesity increases the risk of chronic kidney disease, and this study looked at how a high-fat diet (HFD) affects the kidneys of mice.
  • Mice that ate an HFD for 16 weeks became obese and showed signs of kidney damage, like high protein in urine and bad kidney function.
  • The researchers found that the high-fat diet caused too much fat buildup, increased stress in kidney cells, and led to more cell death, which all hurt kidney health.
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