Publications by authors named "Li Ya Wang"
Article Synopsis
- Delayed healing of infected wounds is due to excessive reactive oxygen species (ROS), leading to tissue damage and a lack of oxygen, which fuels inflammation.
- Existing treatments like hyperbaric oxygen therapy and antibiotics do not sustain oxygen delivery or prevent infections effectively.
- This study introduces a new hydrogel dressing that scavenges ROS and releases oxygen, enhancing cell survival, promoting healing, and providing drug-free infection resistance by modulating the immune response in wounds.
The development of facile tailoring approach to adjust the intrinsic activity and stability of atomically-precise metal nanoclusters catalysts is of great interest but remians challenging. Herein, the well-defined Au nanoclusters modified by single-atom sites are rationally synthesized via a co-eletropolymerization strategy, in which uniformly dispersed metal nanocluster and single-atom co-entrenched on the poly-carbazole matrix. Systematic characterization and theoretical modeling reveal that functionalizing single-atoms enable altering the electronic structures of Au clusters, which amplifies their electrocatalytic reduction of CO to CO activity by ~18.
View Article and Find Full Text PDFCurrent approaches to treating inflammatory bowel disease focus on the suppression of overactive immune responses, the removal of reactive intestinal oxygen species, and regulation of the intestinal flora. However, owing to the complex structure of the gastrointestinal tract and the influence of mucus, current small-molecule and biologic-based drugs for treating colitis cannot effectively act at the site of colon inflammation, and as a result, they tend to exhibit low efficacies and toxic side effects. In this study, nanogel-based multistage NO delivery microcapsules are developed to achieve NO release at the inflammation site by targeting the inflammatory tissues using the nanogel.
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- Lanthanide metal-organic frameworks (Ln-MOFs) are used in LEDs for better solid-state lighting and displays, but they often face challenges like low absorption rates of lanthanide ions.* -
- This study introduces a new design for an energy transfer molecule that enhances energy transfer efficiency due to its rigid, conjugated structure, which helps in the construction of more effective Ln-MOFs.* -
- The resulting Ln-MOFs (Eu-MOF and Tb-MOF) show impressive luminescence properties, with long-lived emissions and high quantum yields, and can be combined with blue phosphors to create a white LED with a strong color rendering index.*
Macrophages are highly heterogeneous and exhibit a diversity of functions and phenotypes. They can be divided into pro-inflammatory macrophages (M1) and anti-inflammatory macrophages (M2). Diabetic wounds are characterized by a prolonged inflammatory phase and difficulty in healing due to the accumulation of pro-inflammatory (M1) macrophages in the wound.
View Article and Find Full Text PDF[Effects of family dignity intervention on male infertility patients and their spouses].
Zhonghua Nan Ke Xue
March 2023
Objective: To investigate the effects of family dignity intervention (FDI) on anxiety, depression, hope level and quality of life (QOL) of male infertility patients and their spouses.
Methods: Using quasi-experimental design, we selected male infertility patients and their spouses undergoing human-assisted reproductive technology (ART) in our Center of Reproductive Medicine from June to December 2022 and divided them into an intervention group (38 couples) and a control group (40 couples). The former underwent a four-stage FDI, including ovulation promotion cycle assessment, family sharing, pre-transplantation interview and post-transplantation follow-up, while the latter received routine nursing.
Article Synopsis
- Endogenous bacterial infections from damaged gastrointestinal (GI) organs can lead to severe systemic inflammatory responses and potentially fatal sepsis, making effective treatment a challenge.
- Current methods like antibiotics and surgery often fail to prevent bacteria from spreading and causing further infection.
- The study introduces a wireless piezo implant that, when combined with ultrasound (US) treatment, disrupts bacterial biofilms around GI wounds, showcasing promising results in both experimental models and theoretical studies for reducing infections.
Article Synopsis
- Photocatalytic degradation using metal-organic frameworks (MOFs) is a promising method for purifying the environment, but their effectiveness is limited by issues like poor electrical conductivity and light absorption.
- Researchers developed three types of Cu-based MOFs with different structures (1D, 2D, and 3D) by varying ligands and their ratios, aiming to enhance performance.
- The 1D chain structure showed significant advantages in charge-separation efficiency and catalytic activity, achieving reaction rates that were 3.2 times and 2.0 times higher than the 2D and 3D structures, respectively.
Article Synopsis
- - Two isomorphic lanthanide compounds, Eu and Gd complexes, were synthesized, showing high stability under acidic and thermal conditions.
- - The complexes demonstrated the ability to detect quinolone antibiotics in water at very low concentrations, with their ratiometric sensing linked to the properties of the Eu ion.
- - The compounds also effectively degraded tetracycline when exposed to visible light, with the underlying mechanisms analyzed using advanced spectroscopy and theoretical calculations.
Article Synopsis
- Landscape morphology research focuses on analyzing the shapes and forms of landscapes, using quantitative analysis and computational models.
- This article explores the polder landscape by selecting five morphology indexes to describe its features and employs a self-organizing map (SOM) to classify these features.
- The results demonstrate that the SOM model effectively categorizes polder morphology and provides a method for analyzing the distribution of different landscape units, contributing valuable insights to landscape architecture.
Article Synopsis
- Luminescent metal-organic frameworks (LMOFs) are recognized for their exceptional photoluminescence and effectiveness in chemical sensing, but their water instability limits practical applications.
- A novel complex called {[Zn(L)]·CHCN} has been developed, which shows better photophysical properties and enhanced water stability through doping with Cu ions.
- The Cu/Zn-MOF exhibits excellent detection capabilities for various metal ions and antibiotics, demonstrating high sensitivity, fast response times, and long-term reliability in water-based environments.
Article Synopsis
- Acute kidney injury (AKI) is a serious condition linked to oxidative stress, often needing only supportive treatments like rehydration and dialysis, especially during diseases like COVID-19.
- Current treatments using enzyme-mimicking nanoantioxidants face issues like poor compatibility and undesirable effects due to non-specific regulation of reactive oxygen species (ROS).
- The study introduces ultrathin Ti C -PVP nanosheets (TPNS) as a new non-enzymatic antioxidant therapy for AKI, showcasing their effective ROS scavenging, biocompatibility, and potential to reduce inflammation through specific signaling pathway inhibition.
An increasing utilization of flexible healthcare electronics and biomedicine-related therapeutic materials urges the development of multifunctional wearable/flexible smart fabrics for personal therapy and health management. However, it is currently a challenge to fabricate multifunctional and on-body healthcare electronic devices with reliable mechanical flexibility, excellent breathability, and self-controllable joule heating effects. Here, we fabricate a multifunctional MXene-based smart fabric by depositing 2D TiCT nanosheets onto cellulose fiber nonwoven fabric special MXene-cellulose fiber interactions.
View Article and Find Full Text PDFClear cell renal cell carcinoma(ccRCC) is the most common type of renal cell carcinoma. While it is curable when detected at an early stage, some patients presented with advanced disease have poor prognosis. We aimed to identify key genes and miRNAs associated with clinical prognosis in ccRCC.
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- - A novel 2D zinc(ii) metal-organic framework (MOF), labeled [Zn(L)(H2O)]·H2O, was created using solvothermal methods and shows strong potential for degrading organic dyes without additional catalysts.
- - The MOF demonstrated impressive degradation rates of 98.5% for rhodamine B and 83.8% for methyl orange in just 120 minutes, achieving higher efficiency than most other MOFs due to its ability to generate effective oxidants.
- - It maintains its catalytic effectiveness even after five uses, suggesting that this MOF could be a viable option for environmental cleaning solutions.
Article Synopsis
- Highly porous luminescent metal-organic frameworks (MOFs) can be used as fluorescent probes for detecting nitro compounds and as containers for host-guest systems.
- Two new 3D MOFs were created using a specific ligand (tppe), showing particularly high sensitivity and selectivity for detecting nitro-antibiotics like furazolidone (FZD).
- The research also demonstrates that these MOFs can emit white light when sulforhodamine 101 (SR101) is encapsulated within their structure, enhancing their versatility.
Article Synopsis
- Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) stem from mutations in the DMD gene, and this study focuses on identifying these mutations to minimize recurrence risk in affected families.
- Researchers examined 100 unrelated DMD/BMD patients and identified pathogenic variants, including 11 novel ones, with the majority being intragenic deletions.
- The study highlights the importance of genetic testing methods like MLPA, NGS, and HMSA and emphasizes that early genetic diagnosis can aid in prenatal options, including the termination of affected pregnancies and the successful birth of healthy children through preimplantation genetic diagnosis (PGD).
Inequality of health services for different specialty categories not only occurs in different areas in the world, but also happens in the online service platform. In the online health community (OHC), health services often display inequality for different specialty categories, including both online views and medical consultations for offline registered services. Moreover, how the city-level factors impact the inequality of health services in OHC is still unknown.
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- Molecule-based solid-state materials with long lifetimes can improve exciton migration distances, which is useful in optoelectronics.
- A hexanuclear zinc cluster-based metal-organic framework (MOF) shows significantly enhanced phosphorescence compared to the original phosphor ligand, improving performance by about 100 times.
- The study demonstrates that the zinc cluster helps optimize the molecular structure and properties of the organic ligands, leading to a cost-effective MOF with potential for various optoelectronic applications, including efficient hydrogen evolution under light.
Article Synopsis
- Recent technology called semiconductor sequencing platform (SSP) can help check for genetic problems before a baby is implanted in a mother's womb.
- Scientists tested this method using DNA from IVF embryos and found it worked well with different DNA amplification tools.
- The SSP method showed it could quickly and accurately identify genetic issues, matching results from an older method, making it a better choice for future genetic testing.
Article Synopsis
- Most children conceived through assisted reproductive technology (ART) are healthy, but there are concerns about potential long-term health effects associated with ART.
- Research using mouse models shows that certain gene alterations linked to heart and metabolic issues are present in mice conceived through ART methods like ICSI and IVM.
- Findings indicate that older mice conceived by ICSI or IVM have higher blood pressure and abnormal lipid levels, suggesting a risk for cholesterol metabolism problems later in life due to ART.
Article Synopsis
- The study examined how graphene nanoplatelets and reduced graphene oxide affect the performance of valve-regulated lead-acid batteries used in electric bikes.
- Results indicated that batteries with graphene additives showed significantly better low-temperature performance, charge acceptance, and large-current discharge performance, with a cycle life improvement of more than 52%, increasing from 250 to 380 cycles.
- The addition of graphene did not notably increase water loss in the batteries, likely because graphene aids in improving charge/discharge processes and prevents lead sulfate crystal growth.
Article Synopsis
- cfDNA screening is a reliable and safe method for detecting fetal chromosome abnormalities, including sub-chromosomal copy number variations (CNVs), in pregnant women.
- In a study involving over 11,000 pregnant women, 137 tested positive for aneuploidies, with a significant portion confirmed through further testing, revealing common trisomies and sex-chromosomal abnormalities.
- The findings suggest that cfDNA screening can indicate potential parental balanced chromosome translocations, highlighting the importance of follow-up diagnostic testing.
Article Synopsis
- A stainless steel fiber was coated with a metal-organic framework called ZIF-7 using a sol-gel method, enabling it to effectively extract aldehydes from the breath of lung cancer patients.
- The optimized extraction conditions resulted in high enrichment factors (300 to 10,000), low detection limits (0.61-0.84 μg L), and wide linear ranges for various aldehydes.
- The modified fiber showed excellent thermal stability and reproducibility, allowing it to be reused more than 150 times, with recovery rates from samples between 84-113%.
Article Synopsis
- This study explores the use of chromosomal microarray analysis (CMA) on products of conception (POC) to identify parental balanced translocations that could contribute to infertility.
- Over a five-year period, 1294 POC samples were analyzed, detecting subchromosomal copy number variations (CNVs) in 16 cases indicative of unbalanced translocation derivatives, all confirmed through parental genetic testing.
- The findings highlight CMA's effectiveness in diagnosing CNVs, particularly for couples where one partner has a hidden balanced translocation without obvious chromosomal abnormalities.