Exploring CX3CR1 as a prognostic biomarker and immunotherapeutic target in sarcoma.

Background: Sarcomas (SARC) are a diverse group of malignant tumors originating from mesenchymal tissues, characterized by poor prognosis under conventional therapies. CX3CR1, a chemokine receptor involved in immune cell migration, has emerged as a key player in SARC. Post-translational modifications (PTMs) such as phosphorylation and ubiquitination critically modulate CX3CR1, influencing cancer progression, immune responses, and treatment resistance.

Executive function is associated with behaviour problems in children and adolescents with cerebral palsy and intellectual disability.

Background: Children and adolescents with cerebral palsy (CP) commonly have behaviour problems. The present study aimed to determine which of the most common clinical features experienced by children and adolescents with CP and intellectual disability are associated with behaviour problems.

Method: We investigated 11 possible associated variables including epilepsy, visual and hearing impairments, motor difficulties, communication and speech difficulties, pain, sleep disturbance, executive function (EF) deficits, type of CP, and parent stress.

Wireless Sensor Network Coverage Optimization Using a Modified Marine Predator Algorithm.

To solve the coverage problem caused by the random deployment of wireless sensor network nodes in the forest fire-monitoring system, a modified marine predator algorithm (MMPA) is proposed. Four modifications have been made based on the standard marine predator algorithm (MPA). Firstly, tent mapping is integrated into the initialization step to improve the searching ability of the early stage.

Hyperprolactinemia complicated with peliosis hepatis: One case report and review of literature.

Rationale: Peliosis hepatis (PH) is a rare disease with few clinical reports and complex etiology. However, there have been no reports of hyperprolactinemia (HPRL) leading to PH at present. This paper, through case reports, expands the understanding of the etiology of PH and the pathological damage effect of prolactin (PRL).

EDNRB negatively regulates glycolysis to exhibit anti-tumor functions in prostate cancer by cGMP/PKG pathway.

Prostate cancer (PCa) is the most prevalent cancer in men and the leading cause of cancer-related mortality. Recent studies have highlighted the pivotal role of glycolysis in tumor progression. This study aimed to investigate the involvement of the EDNRB gene and its ligand endothelin 3 (EDN3) in glycolysis in PCa and to elucidate its underlying molecular mechanism.

Regulation of whey protein emulsion gel's structure with pullulan to enhance astaxanthin bioaccessibility.

In this study, the potential of using an emulsion gel based on whey protein concentrate (WPC) and pullulan (PUL) to encapsulate and deliver astaxanthin (AST) was investigated. PUL concentration was observed to affect the microstructure of WPC/PUL/AST emulsion gels, and the performance of emulsion gels was evaluated by encapsulation efficiency, simulated gastrointestinal digestion, storage stability, hardness, and water holding capacity tests. The WPC/PUL/AST emulsion gels had the highest encapsulation efficiency, gastrointestinal digestion retention, and bioaccessibility of (91.

Effects of exercise on bone mass and bone metabolism in adolescents: a systematic review and meta-analysis.

Objective: Meta-analysis was used to evaluate the effects of an exercise intervention on bone mineral content (BMC), bone mineral density (BMD), and bone metabolism in adolescents.

Methods: A systematic search of PubMed, Embase, Cochrane Library, and Web of Science for RCTs on "exercise, adolescents, BMD, bone metabolism" up to 10 September 2024. Included RCTs focused on effects of exercise on BMC, BMD, and bone metabolism in 10-19 years old, with physical activity as exercise group and daily living/primal exercise as control group.

A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor-specificity.

P-cadherin (pCAD) and LI-cadherin (CDH17) are cell-surface proteins belonging to the cadherin superfamily that are both highly expressed in colorectal cancer. This co-expression profile presents a novel and attractive opportunity for a dual targeting approach using an antibody-drug conjugate (ADC). In this study, we used a unique avidity-driven screening approach to generate pCAD x CDH17 bispecific antibodies that selectively target cells expressing both antigens over cells expressing only pCAD or only CDH17.

Emamectin·chlorfenapyr-induced fatal leukoencephalomyelopathy with delayed hyperthermia: insecticide endanger public safety.

Background: Emamectin·chlorfenapyr is a compound comprising chlorfenapyr and emamectin benzoate that is widely used in agriculture. Chlorfenapyr toxicity has been verified in animals; however, its true mechanism and progression in humans remain to be elucidated. Cases of emamectin·chlorfenapyr poisoning are seldom.

Biodiesel Production from Soybean Oil Using a Free-Enzyme and Whole-Cell Dual Lipase System as a Biocatalyst.

A dual lipase system has been developed to convert soybean oil into biodiesel through synergistic catalysis of Thermomyces lanuginosus lipase (TLL) and Yarrowia lipolytica lipase 2 (YLL) in this study. Pichia pastoris recombinant strains expressing lipases were successfully constructed, and the activities of TLL and YLL in the fermentation supernatant reached 23,142.71 ± 280.

Effectiveness and Safety of Shenxiong Huanglian Detoxification Granule Combined with Donepezil for the Treatment of Alzheimer's Disease: Study Protocol for a Multicenter, Pragmatic, Randomized Controlled Clinical Trial.

Background: Alzheimer's disease is a degenerative condition that causes patients to experience progressive memory decline and a significant decline in overall cognitive ability at any given moment. The increase in the elderly population has resulted in a notable surge in the prevalence of Alzheimer's disease, as has the global impact of the disease. Significant clinical efficacy of traditional Chinese medicine in combination with Western medicine for the treatment of Alzheimer's disease has been demonstrated in previous studies.

Oral bacteriophage therapy effectively prevent and control of Clostridium perfringens type c infections in newborn piglets.

Clostridium perfringens (C. perfringens) type C exhibits strong pathogenicity, often leading to swine dysentery, severely affecting the economic efficiency of the pig farming industry. Bacteriophages as bacterial viruses have many natural advantages and are potent candidates for controlling bacterial infections.

Biodiesel Production from Waste Oil Through Efficient Enzymatic Synthesis Using Yarrowia lipolytica Lipase 2 in the Presence of Glucose, β-Cyclodextrin, or G50.

In this study, the liquid lipase Yarrowia lipolytica lipase 2 (YLLip2) expressed by Pichia pastoris GS115 was used to produce biodiesel from waste oil. Four signal peptides were compared to express YLLip2 in P. pastoris, among which SP23 exhibited greater secretion performance.

Combined fermentation and ARTP mutagenesis to enhance lipase activity of Penicillium camembertii and its application for high-purity 1,3-diacylglycerol preparation.

Penicillium camembertii lipase (PCL) is a glycerol-biased enzyme isolated from P. camembertii, exhibiting high esterification activity. The PCL activity was enhanced by combining fermentation optimization with atmospheric and room temperature plasma (ARTP) mutagenesis.

Preparation, characterization, stability and functional properties of andrographolide loaded kafirin/carboxymethyl cellulose composite particles using antisolvent precipitation method.

Enhancing the oral bioavailability of hydrophobic nutraceuticals and protecting bioactive components through encapsulation systems has gained significant attention in food science. This study explored the preparation and characterization of kafirin (Kaf)/carboxymethyl cellulose (CMC) composite nanoparticles for encapsulating andrographolide (AG) using the antisolvent precipitation method. The optimal Kaf to CMC mass ratio was identified as 4:1, resulting in nanoparticles with an average diameter of 146.

PTD-FNK Alleviated LPS-Induced Oxidative Stress of Boar Testicular Sertoli Cells via Keap1-Nrf2 Pathway.

PTD-FNK, a synthetic anti-apoptotic protein, has been shown to potently alleviate cellular injuries. However, the effects of PTD-FNK on oxidative defense in boar testicular Sertoli cells (SCs) against oxidative injury has not been explored. In this study, we show that exposure of SCs to 100 mg/L lipopolysaccharide (LPS) for 12 h leads to decreased survival rate, superoxide dismutase (SOD) activity, and increased malondialdehyde (MDA).

Flexible Ge/Cu/ZnSe multilayer photonic structures for triple-band infrared camouflage, visible camouflage, and radiative cooling.

With the rapid advancement of multi-band detection technologies, military and civilian equipment face an increasing risk of being detected, posing significant challenges to traditional single-band camouflage designs. To address this issue, this study presents an innovative multilayer structure using Ge, Cu, and ZnSe materials to achieve triple-band infrared camouflage, visible camouflage, and radiative cooling. The structure exhibits low emissivity in the short-wave infrared (SWIR, 1.

3D coherent single shot lidar imaging beyond coherence length.

Advancements in remote sensing and autonomous vehicle technologies made lidars equally important for unmanned objects alongside cameras. Therefore, precise 3D lidar imaging and point cloud generation have become important subjects. Although existing coherent lidar technologies provide precise imaging results, the spectral linewidth of the laser sources becomes a key limitation over long distances as it defines the maximum detection range.

Robust and sensitive colorimetric detection of glutathione with double-triggering MOF-Fe(DTNB).

Glutathione (GSH) levels have been well validated to correlate with a variety of physiological and pathological conditions, such as malignancy, cardiovascular disease and aging, making the development of accurate, robust and sensitive GSH detection methods highly desirable. In this study, a novel metal-organic framework (MOF-Fe(DTNB))-based colorimetric method with a favorable dual-triggering function was proposed. MOF-Fe(DTNB) exhibits high peroxidase activity, which can catalyze the oxidation of colorless 3,3',5,5'-tetramethylbenzidine (TMB) to blue ox-TMB by hydrogen peroxide (HO).