Publications by authors named "Li Xingchen"
As the most common and lethal cancer of the female gonads, ovarian cancer (OC) has a grave impact on people's health. OC is asymptomatic, insidious in onset, difficult to diagnose and treat, fast-growing, and easy to metastasize and has poor prognosis and high mortality. How to detect OC as early as possible and treat it without side effects has become a challenging medical problem.
View Article and Find Full Text PDFTongue squamous cell carcinoma (TSCC) is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion. Accurate diagnosis and effective treatment are essential for enhancing the quality of life and the survival rates of TSCC patients. The current treatment modalities for TSCC frequently suffer from a lack of specificity and efficacy.
View Article and Find Full Text PDFSubsidence lakes, formed due to extensive underground coal mining activities, present both ecological challenges and opportunities for alternative land use practices, such as photovoltaic power generation and aquaculture. However, the ecological consequences of these anthropogenic activities on bacterial communities within subsidence lakes remain largely unexplored. To address this knowledge gap, we conducted a comprehensive investigation of bacterial communities in two typical subsidence lake districts located in Huainan, Anhui Province, China.
View Article and Find Full Text PDFArticle Synopsis
- - The CuO@Au nanozyme is developed as a "tumor energy homeostasis disruptor" for lung cancer treatment, effectively blocking the tumor's energy supply while enhancing chemodynamic therapy (CDT) by continuously producing reactive oxygen species (ROS) and lowering pH.
- - This nanozyme not only depletes glucose at the tumor site but also reduces the uptake of cysteine in cancer cells, leading to increased ROS production and ultimately causing cancer cell death through lipid peroxidation (ferroptosis).
- - Additionally, CuO@Au offers photothermal capabilities and imaging features, making it a multifunctional tool that synergizes starvation therapy, CDT, and photothermal therapy (PTT) for more
Article Synopsis
- Endometrial cancer (EC) is the most prevalent gynecologic cancer, but its poor prognosis is largely due to inadequate screening and treatment options.
- A study involving 834 EC patients identified significant predictive factors for overall and recurrence-free survival using specific immunohistochemical (IHC) indicators and a range of clinicopathological variables.
- The study developed two predictive models, showing improved accuracy in forecasting patients' survival rates, which can help inform treatment plans and follow-up care to potentially increase long-term survival rates.
Article Synopsis
- A study evaluated the performance of large language models (LLMs), specifically ChatGPT and Bard, in pathology by comparing their scores on multiple-choice questions against those of 16 pathology trainees from two hospitals.
- ChatGPT outperformed both Bard and the trainees, scoring an average of 82.2%, while Bard scored 49.5% and junior and senior trainees scored 45.1% and 56.0%, respectively.
- The consistency of ChatGPT's responses was notably high (80%-85%), while Bard showed more variability (54%-61%), indicating the potential of LLMs in pathology education but emphasizing the need for further development and human input.
Nanozymes as Glucose Scavengers and Oxygenerators for Enhancing Tumor Radiotherapy.
ACS Appl Mater Interfaces
November 2024
Insufficient accumulation of reactive oxygen species (ROS) due to tumor hypoxia significantly contributes to increased radiation resistance and the failure of radiotherapy (RT). Therefore, developing methods to alleviate hypoxia and boost ROS levels represents a promising strategy for enhanced radiosensitivity. This study introduced a self-cascade catalytic Pt@Au nanozymes as a radiosensitizer, using glucose oxidase (GOx)-, catalase (CAT)-, and peroxidase (POD)-like activities to improve hypoxia and increase ROS accumulation, thereby affecting glucose metabolism and enhancing the effects of RT.
View Article and Find Full Text PDFOral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck region, and its treatment is limited by hypoxia and inadequate oxygen supply. Continuous oxygen delivery combined with photodynamic therapy (PDT) is the key to addressing this issue. Here, a dual-enzyme activity sea urchin-like Au@Pt-Ce6-HN-1 nanoplatform was designed to serve as an "oxygen pump" to alleviate tumor hypoxia for synergistic photodynamic/photothermal therapy (PTT).
View Article and Find Full Text PDF"All-in-one" tea polyphenol-modified injectable hyaluronic acid-based hydrogel for diabetic wound healing.
Int J Biol Macromol
November 2024
Article Synopsis
- * A new multifunctional supramolecular hyaluronic acid hydrogel dressing (GHPM) has been developed, showcasing properties like excellent tissue adhesion, antibacterial action, conductivity, and antioxidant capabilities, while also maintaining injectable and self-healing functions.
- * Treatment with the GHPM hydrogel accelerates wound healing by preventing infections and promoting collagen deposition, especially when combined with electrical stimulation, which enhances angiogenesis and neurogenesis for better overall recovery.
Article Synopsis
- The study examines the impact of lymph-vascular space invasion (LVSI) on the prognosis of early-stage low-grade endometrioid endometrial cancer (EEC) in a Chinese patient cohort from 2006 to 2020.
- Researchers analyzed data from 702 patients, finding that those with LVSI had higher recurrence rates and lower 5-year disease-free and overall survival rates compared to LVSI-negative patients.
- LVSI was identified as an independent risk factor for poor prognosis in this cancer type, supporting its inclusion in risk assessment guidelines.
Article Synopsis
- Light significantly affects photosynthesis, bud flush timing, and growth in tea plants, specifically in the albino cultivar 'HuangKui'.
- This study explores various photoperiods and light ratios (red and blue) to determine their impact on germination, growth indicators, and chlorophyll content in 'HuangKui'.
- Results show that a 16L/8D photoperiod with a red/blue light ratio of 2:1 promotes earlier germination and increased growth compared to other light treatments.
Article Synopsis
- Reactive oxygen species (ROS) are crucial for tissue repair, but an imbalance in redox homeostasis can hinder bone healing, necessitating better bone scaffold materials.
- The study developed a 3D-printed biodegradable bio-scaffold (FPBS) using mussel-inspired polydopamine and nanoparticles that effectively scavenges ROS while promoting bone formation in a stressed environment.
- FPBS demonstrated strong biocompatibility, enhanced stem cell osteogenesis, and significantly improved bone regeneration in a rat model, indicating its potential for effective bone defect repair.
Unraveling the efficacy of verbascoside in thwarting MRSA pathogenicity by targeting sortase A.
Appl Microbiol Biotechnol
June 2024
Article Synopsis
- * The study demonstrated that verbascoside has protective effects against MRSA infections in various in vivo models.
- * Targeting key virulence factors like SrtA with compounds like verbascoside presents new strategies to combat antibiotic resistance.
Article Synopsis
- * Researchers developed a mineralized hydrogel (PVA-Ag-PHA) that incorporates green-synthesized silver nanoparticles, which provides strong antibacterial effects while promoting bone growth and healing.
- * The PVA-Ag-PHA hydrogel not only eliminates harmful bacteria but also enhances the local release of calcium and phosphate ions, creating a bioactive environment that supports cell adhesion and accelerates bone regeneration in a rat model.
Aiming to address the problem of robot path planning in environments containing narrow passages, this paper proposes a novel global path planning method: the DSR (Dual-source Light Continuous Reflection Exploration) algorithm. This algorithm, inspired by the natural reflection of light, employs the concept of continuous reflection for path planning. It can efficiently generate an asymptotically optimal path on the map containing narrow passages.
View Article and Find Full Text PDFAdvancing Spinal Cord Injury Bioimaging and Repair with Multifunctional Gold Nanodots Tracking.
ACS Appl Mater Interfaces
April 2024
Article Synopsis
- - High levels of reactive oxygen species (ROS) contribute significantly to the damage following spinal cord injury (SCI), making ROS scavenging a possible treatment strategy to improve recovery.
- - Ultra-small gold nanodots (AuNDs) were developed as a biomaterial that both reduces ROS and enhances imaging for identifying SCI locations, facilitating better diagnosis and treatment.
- - The AuNDs not only protect against oxidative stress and inflammation but also provide clear imaging contrast between injured and healthy spinal cord areas, offering a new avenue for effective SCI management.
Article Synopsis
- The study examines the role of Hepatitis B virus (HBV) integrations in causing liver cancer (hepatocellular carcinoma, or HCC) by exploring their genomic structures in 124 samples.
- It identifies complex integration patterns and mechanisms that lead to various genetic changes associated with tumor development, with a focus on specific chromosome alterations.
- The findings suggest that HBV integrations significantly influence genomic rearrangement, which is linked to factors like age and HBV DNA levels, enhancing understanding of how HBV contributes to cancer.
Article Synopsis
- Fertility preservation is crucial for patients with apical endometrial hyperplasia (AEH) and early endometrial cancer (EEC), with complete regression (CR) being the main treatment goal.
- A study of 193 patients analyzed 24 clinical factors using LASSO regression to create a nomogram for predicting CR after fertility treatment, resulting in a strong predictive model called GLOBAL.
- The GLOBAL model, which includes eight key risk factors, showed high accuracy (AUC of 0.907) in predicting CR and indicated varied cumulative CR rates among different patient groups.
Article Synopsis
- This study investigates how the metabolic risk score (MRS) influences the time it takes for patients with atypical endometrial hyperplasia (AEH) and early endometrial cancer (EC) to reach complete remission (CR) after fertility-sparing treatments.
- Researchers used various statistical analyses to identify independent risk factors affecting CR and found that MRS significantly improved the accuracy of predicting time to CR.
- The findings suggest that MRS is a valuable tool for assessing patients' outcomes, helping to predict remission times more effectively in those seeking to preserve fertility.
Targeting CD24/Siglec-10 signal pathway for cancer immunotherapy: recent advances and future directions.
Cancer Immunol Immunother
January 2024
Article Synopsis
- CD24 is a heavily glycosylated protein found in immune cells and cancer cells, serving as a crucial cancer biomarker and interacting with Siglec-10 to modulate inflammation in diseases.
- The binding of CD24 to Siglec-10 helps inhibit inflammation linked to SHP-1/2 phosphatases and reduces macrophage activity, which can impact the immune response to cancer.
- The study highlights recent advances in CD24/Siglec-10-targeted immunotherapy, suggesting it as a promising approach in cancer treatment and discussing potential future research directions based on recent trial outcomes.
Article Synopsis
- Decision-makers often struggle with numerical evaluations when they feel hesitant, and hesitant fuzzy linguistic term sets offer a way to express that hesitancy effectively.
- In multi-attribute group decision-making, differing preferences among decision makers can lead to losses in important information if their varying assessments are not properly considered.
- The proposed three-way decision-making model addresses these challenges by using D-S evidence theory for better information fusion and incorporates cost functions for alternatives, demonstrating its effectiveness through examples and experiments, making it suitable for intelligent classification and recommendation systems.
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- Curcuma wenyujin is a significant Daodi herb from Zhejiang province, known for its traditional uses in promoting Qi flow, activating blood circulation, and alleviating depression.* -
- Modern research highlights its various health benefits, including anti-tumor and anti-inflammatory properties, attributed to its rich composition of sesquiterpenoids and curcumins.* -
- The paper reviews recent studies on its chemical makeup and medicinal uses, while proposing quality markers (Q-markers) to improve quality evaluation and support further research and application of this herb.*
Article Synopsis
- - The study investigates how PIK3CA mutations in luminal breast cancer contribute to an immunosuppressive tumor microenvironment by recruiting myeloid-derived suppressor cells (MDSCs) and reducing cytotoxic T cells, linked to the arachidonic acid metabolism pathway.
- - Through various advanced techniques, the research identifies that PIK3CA activates the 5-LOX enzyme in a STAT3-dependent manner, leading to increased levels of LTB4, which promotes MDSC infiltration into tumors.
- - The findings suggest that targeting the PI3K/5-LOX/LTB4 axis alongside immune checkpoint blockade therapies may effectively convert "cold" tumors, which resist immunotherapy, into "hot"
Article Synopsis
- Surgery, radiotherapy (RT), and brachytherapy are important methods for treating localized tumors, but inaccuracies in tumor location can lead to complications like damaged healthy tissue and ineffective treatment.
- The new theranostic platform using Au/Ag nanodots (Au/AgNDs) offers real-time guidance for these treatments, increasing the precision of RT and improving outcomes in brachytherapy.
- Au/AgNDs enhance tumor targeting through dual-mode imaging, which boosts radiation efficacy, distinguishes tumors from normal tissue, and assists surgeons during operations, collectively improving cancer treatment strategies.