The characteristics of patients with multiple myeloma surviving over 10 years.

Objective: To explore the characteristics of patients with multiple myeloma (MM) who have achieved long-term survival of over 10 years in the context where novel agents and autologous stem cell transplantation (ASCT) serve as the primary therapeutic modalities.

Methods: A retrospective analysis was conducted on 168 MM patients diagnosed and treated in our institution from January 2004 to January 2014. 44 patients with a survival period exceeding 10 years were categorized into the long-term survival group, while 124 patients with a survival period of less than 10 years were categorized into the non-long-term survival group.

High precision single-photon object detection via deep neural networks.

Single-photon imaging is an emerging technology in sensing that is capable of imaging and identifying remote objects under extreme conditions. However, it faces several challenges, such as low resolution and high noise, to do the task of object detection. In this work, we propose an enhanced You Only Look Once network to identify and localize objects within images generated by single-photon sensing.

Clinical characteristics and risk factors of infection in initially treated patients with multiple myeloma during the induction period.

Background: Multiple myeloma (MM) is a common hematologic malignancy and immune dysfunction is a hallmark of the disease. It leads to an increased infection risk, which is still a major cause of mortality. The infection spectrum and characteristics have evolved with the introduction of novel agents.

The identification and correction of pseudohypercalcemia.

Background: We found that a subset of patients with monoclonal gammopathy exhibited hypercalcemia without apparent causes or clinical manifestations In a cohort of 289 monoclonal gammopathy patients, 2.4% presented with such atypical hypercalcemia, with one notable case exhibiting normal ionized calcium levels, suggesting the presence of pseudohypercalcemia.

Objective: The aim of this study is to elucidate the factors contributing to pseudohypercalcemia in monoclonal gammopathy and to develop a novel globulin-corrected calcium formula for clinical application.

Foreign waste ban and green development of Chinese manufacturing industry: Comprehensive evidence based on provincial data.

Since the reform and opening up, imported solid wastes have pushed China's economic growth while also bringing about serious environmental problems. In this context, China has introduced a ban on "foreign waste" for imported solid waste. Based on the provincial panel data from 2010 to 2020, this paper calculates the Green Total Factor Productivity (GTFP) of the manufacturing industry to measure the level of green development of the manufacturing sector, and evaluates the comprehensive impact of the "foreign waste" ban on the green development of the manufacturing industry by using the continuous Difference-in-Differences method.

Brain targeted biomimetic siRNA nanoparticles for drug resistance glioblastoma treatment.

Glioblastoma multiforme (GBM), the most aggressive intracranial neoplasm, remains incurable at present, primarily due to drug resistance, which significantly contributes to elevated recurrence rates and dismal prognosis. Signal transducer and activator of transcription 3 (STAT3) is a critical gene closely associated with GBM drug resistance and the progression of GBM stem cells (GSCs), making it a promising therapeutic target. In this study, we developed cancer cell membrane-cloaked biomimetic nanoparticles to deliver STAT3 siRNA to reverse drug resistance in homologous GBM.

Effects of SpGSH1 and SpPCS1 overexpression or co-overexpression on cadmium accumulation in yeast and Spirodela polyrhiza.

Cadmium (Cd) is one of the most toxic elements to all organisms. Glutathione (GSH)-dependent phytochelatin (PC) synthesis pathway is considered an extremely important mechanism in Cd detoxification in plants. However, few studies have focused on the roles of glutamate-cysteine ligase (GSH1) and phytochelatin synthase (PCS1) in Cd accumulation and detoxification in plants.

Chiral Phonons: Prediction, Verification, and Application.

Chirality as an asymmetric property is prevalent in nature. In physics, the chirality of the elementary particles that make up matter has been widely studied and discussed, and nowadays, the concept has developed into the field of phonons. As an important fundamental excitation in condensed matter physics, phonons are traditionally considered to be linearly polarized and nonchiral.

An improved technology for monitoring groundwater flow velocity and direction in fractured rock system based on colloidal particles motion.

The colloidal borescope, using colloidal particle motion, is used to monitor the flow velocities and directions of groundwater. It integrates advanced techniques such as microscopy, high-speed photography, and big data computing and enjoys high sensitivity at the micron level. However, In the same well, the groundwater flow velocity monitored by colloidal hole mirror is varies greatly from that obtained by conventional hydrogeological monitoring, such as pumping test.

YOLOH: You Only Look One Hourglass for Real-Time Object Detection.

Multi-scale detection based on Feature Pyramid Networks (FPN) has been a popular approach in object detection to improve accuracy. However, using multi-layer features in the decoder of FPN methods entails performing many convolution operations on high-resolution feature maps, which consumes significant computational resources. In this paper, we propose a novel perspective for FPN in which we directly use fused single-layer features for regression and classification.

Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults.

Background: Little is known about the association of longitudinal dynamics between cognitive function and frailty in Chinese older adults. The temporal sequences between cognitive function and frailty remains unclear. Our study investigates this directionality association using longitudinal data.

GIS model for geothermal advantageous target selection.

As the particularly popular green energy, geothermal resources are gradually favored by countries around the world, and the development model centered on geothermal dew point cannot meet the increasing geothermal demand. In this paper, a GIS model combining PCA and AHP is proposed, aiming to select the advantages of geothermal resources at the regional scale and analyze the main influencing indicators. Through the combination of the two methods, both data and empirical can be considered, then the geothermal advantage distribution on the area can be displayed through GIS software images.

RUNX2 promotes the suppression of osteoblast function and enhancement of osteoclast activity by multiple myeloma cells.

RUNX2 is a transcription factor that participates in osteoblast differentiation and chondrocyte maturation and plays an important role in the invasion and metastasis of cancers. With the deepening of research, evidence has indicated the correlation between RUNX2 and bone destruction in cancers. However, the mechanisms underlying its role in multiple myeloma remain unclear.

Visual field improvement after endoscopic transsphenoidal surgery in patients with pituitary adenoma.

Purpose: To analyze and predict the possibility of visual field (VF) recovery after endoscopic transsphenoidal surgery (ETSS) in patients with pituitary adenoma, we investigated the factors affecting the improvement of the visual field defect (VFD) and built a nomogram predictive model based on these risk factors. We further investigated specific recovery regions of VF associated with the improvement of VFD.

Methods: The clinical data of patients who underwent ETSS for pituitary adenomas at a single center between the January 2021 and April 2022 were retrospectively analyzed.

Development and validation of a chemotherapy tolerance prediction model for Chinese multiple myeloma patients: The TM frailty score.

Objective: The physical fitness of older individuals is heterogeneous, making it difficult to know their chemotherapy tolerance. The toxicities may offset the benefits of anti-myeloma therapy in frail patients. The accurate evaluation of frailty status before chemotherapy is essential.

Research of nuclide identification method based on background comparison method.

Radioactive material inspection in public is important to nuclear safety, and it is also the key security for holding large-scale events, while fast and efficient means of detecting radioactive materials are an important technical guarantee for nuclear safety. In this paper, energy and time distribution characteristics information of the natural background and target nuclide gamma particles are used to improve the sequential background comparison method. By using those energy and time distribution characteristics information, with the half-life and characteristic gamma-ray energy and branching ratio information of the nuclide, the response time and the identification accuracy of extremely low radioactive nuclides detected under natural-radiation background can be improved.

Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review.

Purpose: In the past few decades, acromegaly and colonic polyps have been associated with an increased risk of colorectal cancer. Previous studies highlighted the importance of serum biomarkers of colonic polyps in patients with acromegaly.

Methods: We reviewed studies on serum biomarkers of colonic polyps in patients with acromegaly, published on PubMed, Embase, Cochrane Library, Medline, and Chinese databases from January 1, 1966, to May 8, 2022.

Pyridoxine Is Effective for Preventing Hand-Foot Syndrome Induced by Pegylated Liposomal Doxorubicin for Multiple Myeloma: The Results of a Randomized Study.

Purpose: Pegylated liposomal doxorubicin (PLD) is highly effective for treating multiple myeloma (MM). Hand-foot syndrome (HFS) is a dose-limiting adverse event of PLD that may reduce a patient's quality of life or prevent certain patients from receiving PLD. Several researchers have discovered that pyridoxine, an activated form of vitamin B6, may prevent PLD-associated HFS.

Genome-Wide Analysis of the Growth-Regulating Factor (GRF) Family in Aquatic Plants and Their Roles in the ABA-Induced Turion Formation of .

Growth-regulating factors (GRFs) are plant-specific transcription factors that play essential roles in regulating plant growth and stress response. The gene families have been described in several terrestrial plants, but a comprehensive analysis of these genes in diverse aquatic species has not been reported yet. In this study, we identified 130 genes in 13 aquatic plants, including floating plants (, , , , and ), floating-leaved plants ( and ), submersed plants (, , , and ), an emergent plant (), and an amphibious plant ().

A fast gamma-ray source localization method for mobile robots.

A method for fast estimation of radioactive source parameters is presented. Full use was made of multiple continuous count values, combined with triangulation with four-point sampling method to solve high-dimensional optimization to obtain initialized estimates, which converge to maximum likelihood estimation using an improved hill-climbing algorithm. Cobalt-60 search experiments were conducted in the laboratory using a mobile robot carrying a NaI(TI) detector.

Identification and expression analysis of GARP superfamily genes in response to nitrogen and phosphorus stress in Spirodela polyrhiza.

Background: GARP transcription factors perform critical roles in plant development and response to environmental stimulus, especially in the phosphorus (P) and nitrogen (N) sensing and uptake. Spirodela polyrhiza (giant duckweed) is widely used for phytoremediation and biomass production due to its rapid growth and efficient N and P removal capacities. However, there has not yet been a comprehensive analysis of the GRAP gene family in S.

Prognostic Significance of the Stage at Which an MRD-Negative Status Is Achieved for Patients With Multiple Myeloma Who Received ASCT.

Objective: To explore the prognostic significance of the stage at which a minimal residual disease (MRD)-negative status is achieved for patients with newly diagnosed multiple myeloma (NDMM) who received autologous hematopoietic stem cell transplantation (ASCT).

Cases And Methods: A retrospective analysis of 186 NDMM patients who received "induction therapy-ASCT-maintenance therapy" in our center and achieved an MRD-negative status was performed. Patients were divided into three groups, A (induction therapy), B (3 months after ASCT), and C (maintenance therapy), according to the stage at which an MRD-negative status was achieved.

Identification, Structural, and Expression Analyses of Genes in Giant Duckweed () Reveals Its Role in Response to Low Phosphorus and Nitrogen Stresses.

genes play important roles in the coordinated utilization of nitrogen (N) and phosphorus (P) in plants. However, a genome-wide analysis of the family is still lacking. In this study, the gene structure and phylogenetic relationship of 160 genes were systematically analyzed at the genome-wide level.

Brain-Targeted Codelivery of Bcl-2/Bcl-xl and Mcl-1 Inhibitors by Biomimetic Nanoparticles for Orthotopic Glioblastoma Therapy.

Glioblastoma (GBM) is among the most treatment-resistant solid tumors and often recurrs after resection. One of the mechanisms through which GBM escapes various treatment modalities is the overexpression of anti-apoptotic Bcl-2 family proteins (., Bcl-2, Bcl-xl, and Mcl-1) in tumor cells.