CT-based nomogram predicts esophageal gastric variceal bleeding in noncirrhotic portal hypertension caused by hepatic schistosomiasis.

Background: To construct a nomogram combining CT varices vein evaluation and clinical laboratory tests for predicting the risk of esophageal gastric variceal bleeding (EGVB) in patients with noncirrhotic portal hypertension (NCPH).

Methods: A total of 315 NCPH patients with non-EGVB and EGVB were retrospectively enrolled and randomly divided into training and testing cohorts. Thirteen collateral vessels were identified and evaluated after CT portal vein system reconstruction.

GYY4137 ameliorates blood brain barrier damage by inhibiting autophagy mediated occludin degradation in cardiac arrest and resuscitation.

Cardiopulmonary resuscitation (CPR) after cardiac arrest (CA) is an important cause of neurological impairment and leads to considerable morbidity and mortality. The stability of the blood-brain barrier (BBB) is crucial for minimizing secondary neurological damage and improving long-term prognosis. However, the precise mechanisms and regulatory pathways that contribute to BBB dysfunction after CPR remain elusive.

Prediction models for sarcopenia risk in dialysis patients: a systematic review and critical appraisal.

Background: Many studies have developed or validated predictive models to estimate the risk of sarcopenia in dialysis patients, but the quality of model development and the applicability of the models remain unclear.

Objective: To systematically review and critically evaluate currently available predictive models for sarcopenia in dialysis patients.

Methods: We systematically searched five databases until March 2024.

NK Cell Exosomes Alleviate PD-L1 Expression and Facilitate Tumor Immunity by Repressing PI3K-AKT-mTOR Signaling.

Background: Liver cancer (LC) is a deadly malignancy with limited therapeutic options in recent years. Natural killer cell-derived exosomes (NK-exo), as an important bridge of information transmission between cells, also have a certain killing effect on tumor cells. On this basis, this study investigated the specific regulatory mechanism of NK-exo on LC cells.

Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: implications for metabolic and transport interactions.

Wogonin is a flavonoid with efficacy in ulcerative colitis (UC), while the mechanism of its action remains to be fully elucidated. Previous research has indicated that the activation of the triple recycling pathway significantly enhances the bioavailability of flavonoids. The efflux transporters, BCRP and MRP2 are critical regulatory molecules within the enterohepatic triple recycling pathways.

Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment.

Cardiovascular diseases (CVDs) are the leading cause of mortality among individuals with noncommunicable diseases worldwide. Obesity is associated with an increased risk of developing cardiovascular disease (CVD). Mitochondria are integral to the cardiovascular system, and it has been reported that mitochondrial transfer is associated with the pathogenesis of multiple CVDs and obesity.

Deciphering the N-substituent effects on biodegradation of sulfonamides: Novel insights revealed from molecular biology and computational chemistry approaches.

Elucidating biodegradation mechanisms and predicting pollutant reactivities are essential for advancing the application of biodegradation engineering to address the challenge of thousands of emerging contaminants. Molecular biology and computational chemistry are powerful tools for this purpose, enabling the investigation of biochemical reactions at both the gene and atomic levels. This study employs the biodegradation of ten sulfonamide antibiotics as a case study to demonstrate the integration of genomics and quantum chemistry approaches in exploring the biodegradation behavior of emerging contaminants.

Development of a set of indicators for the quality of chronic pain management in Chinese community-dwelling older adults: a Delphi study.

Background: Standardized and systematic quality assessments of chronic pain management, particularly among older adult populations, are lacking in resource-limited community settings. A specific set of indicators to evaluate the quality of chronic pain management in this population has yet to be developed. Therefore, the present study constructed a set of indicators to assess the quality of chronic pain management in Chinese community-dwelling older adults, providing a standardized reference and guidance for community health centers to manage chronic pain in this population.

Chinese translation, cross-cultural adaptation, and psychometric validation of patient-reported outcome measurement- questionnaire about gynecological and pelvic pain symptoms (ENDOPAIN-4D).

Objectives: The aim of this study was to cross-culturally translate a questionnaire about gynecological and pelvic pain symptoms (ENDOPAIN-4D) patient-reported outcome measurement (PROM) into Chinese and evaluate its reliability and validity.

Methods: The questionnaire was translated according to Brislin's classic back-translation model. We conducted cultural debugging through cognitive interviews with Chinese-speaking women who had experienced pelvic pain (n = 24).

Hemorrhage risk after coblation tonsillectomy in Chinese pediatric: a multicenter, prospective, observational cohort study.

Objectives: The study aimed to assess the incidence of post-coblation tonsillectomy hemorrhage (PCTH) and identify associated risk factors in a pediatric Chinese population.

Methods: This prospective, multicenter cohort study, conducted over 17 months, included 8854 pediatric patients who underwent coblation tonsillectomy across 15 research centers in China. Patient data were collected through an Electronic Data Capture (EDC) system.

Establishment of a survival rabbit model for laryngotracheal stenosis: A prospective randomized study.

Objective: To develop a reproducible survival rabbit model for laryngotracheal stenosis (LTS).

Methods: Seventy New Zealand white (NZW) rabbits were randomly divided into experimental groups ( = 30) and a control group ( = 40). In experimental groups, a nylon brush was inserted retrograde from the tracheotomy through the subglottis and rotated until a full layer circumferential mucosal injury to cartilage exposure, assisted by fiberoptic laryngoscopy (FOL) visualization.

Molecular investigation of an epidemic dissemination of vancomycin-resistant Enterococcus faecium sequence type 80 in Guangdong Province, China.

Objectives: The detection rate of vancomycin-resistant Enterococcus faecium (VREfm) displayed a dramatically increase in Guangdong, China from 2021 to 2023, for which the molecular epidemiology and genomic characteristics remain largely unexplored. In this study, we investigated the genetic features and epidemiology of VREfm isolates in Guangdong.

Methods: A total of 54 Guangdong VREfm isolates were collected from three tertiary hospitals in Guangdong.

Molecular Epidemiology, Transmission, and Evolution of Rubella Virus Circulating in Tianjin, China, Between 2009 and 2020.

Rubella is listed as a disease that needs to be eliminated worldwide by the World Health Organization. This study aimed to investigate rubella epidemiology and genetic characteristics based on data from 12 years of laboratory-based surveillance (2009-2020) in Tianjin and to provide baseline genotype data for monitoring future rubella control efforts. We collected RV-positive throat swab samples from confirmed rubella cases during 2009-2020 in Tianjin to isolate RV, amplify and sequence target gene fragments, construct phylogenetic trees, and analyze nucleotide homologies.

CD69 Expression is Negatively Associated With T-Cell Immunity and Predicts Antiviral Therapy Response in Chronic Hepatitis B.

Background: The function of CD69 expressed on T cells in chronic hepatitis B (CHB) remains unclear. We aimed to elucidate the roles of CD69 on T cells in the disease process and in antiviral therapy for CHB.

Methods: We enrolled 335 treatment-naive patients with CHB and 93 patients with CHB on antiviral therapy.

The Role of P-Wave Variables in Enhancing Prediction of New-Onset Atrial Fibrillation in Patients With Acute Myocardial Infarction.

Background: After acute myocardial infarction (AMI), it is common to observe new-onset atrial fibrillation (NOAF), which is often related to a negative prognosis. Some P-wave variables (P-wave duration [PWD], P-wave amplitude, and interatrial block [IAB]), reflecting the process of electrical and structural remodeling, could predict the risk of atrial fibrillation (AF). This study aimed to assess the predictive value of P-wave variables for post-AMI NOAF.

cGAS-like receptors drive a systemic STING-dependent host response in Drosophila.

cGAS-like receptor (cGLR)-stimulator of interferon genes (STING) recently emerged as an important pathway controlling viral infections in invertebrates. However, its exact contribution at the organismal level remains uncharacterized. Here, we use STING::GFP knockin reporter Drosophila flies to document activation of the pathway in vivo.

Non-Conjugated Gridized Nanopolymers as an Efficient Hole-Transport Material for Blue Perovskite Light-Emitting Diodes.

Despite the remarkable advancements in perovskite light-emitting diode (PeLED) technology, the development of blue PeLEDs has lagged. The primary bottleneck lies in the difficulty of finding hole transport materials (HTMs) that can both match the energy levels of blue perovskite materials and exhibit efficient hole transport performance. Herein, a novel non-conjugated polyethylene carbazole-based polymer (P-AGCz) is developed that has excellent solution processability and serves as an efficient dopant-free HTM for PeLEDs.

UGCG promotes chemoresistance and breast cancer progression via NF-κB and Wnt/β-catenin pathway activation.

Background: Taxane-based chemotherapy is the primary treatment for triple-negative breast cancer (TNBC), yet clinical outcomes remain unsatisfactory due to the persistence of chemoresistance. Identifying key factors that contribute to chemoresistance and understanding the associated molecular mechanisms is therefore essential.

Method: The GEO databases were utilized to pinpoint factors related to chemoresistance, which were subsequently validated using clinical tissue samples.

Influence of Noncovalent Interaction on the Nucleophilicity and Electrophilicity of Metal Centers in [M(SCNEt)] (M = Ni, Pd, Pt).

A systematic theoretical study was performed on the electrophilic and nucleophilic properties of Group 10 square-planar metal compounds [M(SCNEt)] (M = Ni , Pd , and Pt ) and their complexes. The nucleophilic metal center and coordinated sulfur atom in [M(SCNEt)] facilitate the formation of metal-involving and conventional noncovalent bonds. The presence a heavier metal center results in a more negative electrostatic potential and a larger nucleophilicity, which in turn leads to the formation of stronger metal-involving noncovalent bonds than those formed by a lighter metal center.

The eye movement and gait variability analysis in Chinese patients with Huntington's disease.

Background: Huntington's disease disease (HD) is characterized by motor, cognitive, and neuropsychiatric symptoms. Oculomotor impairments and gait variability have been independently considered as potential markers in HD. But there lacks an integration analysis of eye movement and gait.

Clinical Classification and Management Outcomes of Anterior Segment-Dominated Persistent Fetal Vasculature: The CCPMOH Report.

Purpose: To describe clinical features, management, and outcomes of anterior segment-dominated persistent fetal vasculature (aPFV).

Design: A secondary analysis of aPFV data from a longitudinal cohort study.

Methods: The age and gender of each participant upon initial presentation, along with biological parameters, best-corrected visual acuity, and biomicroscopic assessments were collected.

Spatial microenvironment enhanced photocatalytic reduction of uranyl ions under solar light irradiation.

Photocatalytic reduction of uranyl ions (UO) is an environmentally friendly, energy efficient, and highly effective method for uranium-containing wastewater treatment and uranium recovery. Herein, a novel photocatalytic material CH-8 @NNFO-4 with abundant oxygen vacancies was synthesize by growing Ca(OH) on the surface of Fe doped NaNbO in situ. The Ca(OH) synergizes with the oxygen vacancies, creating a microenvironment that narrows the bandgap and extends the light response range.

Three new species of the genus Oedichirus Erichson, 1839 (Coleoptera: Staphylinidae: Paederinae: Pinophilini) from China.

Three new species of Oedichirus Erichson, 1839 are described: Oedichirus haishengensis Duan, Yue & Li sp. nov. from Guangxi Province, O.

Preparation and properties of β-carotene-loaded sanxan emulsion gel microcapsules.

Sanxan has important application value in the field of bioactive substance delivery. However, the current sanxan emulsion gel method has certain limitations in delivering heat-sensitive lipophilic bioactive substances. In this study, the acid-gelling properties of sanxan were utilized to prepare sanxan emulsion gel microcapsules (SEGMs) by extrusion dripping method.