Background: This study aimed to compare the efficacy and safety of PD-1/L1 inhibitors combined with anlotinib versus PD-1/L1 inhibitors combined with bevacizumab as second-line treatments for advanced NSCLC patients.
Methods: A retrospective analysis was carried out on data from advanced NSCLC patients who received either PD-1/L1 inhibitors combined with anlotinib or PD-1/L1 inhibitors combined with bevacizumab as second-line therapy. Clinical outcomes, including Overall Survival (OS), Progression-Free Survival (PFS), Objective Response Rate (ORR), Disease Control Rate (DCR), and Adverse Events (AEs), were compared between the two treatment groups.
Reactive oxygen species (ROS) play essential roles in both physiological and pathological processes. Under physiological conditions, appropriate amounts of ROS play an important role in signaling and regulation in cells. However, too much ROS can lead to many health problems, including inflammation, cancer, delayed wound healing, neurodegenerative diseases (such as Parkinson's disease and Alzheimer's disease), and autoimmune diseases, and oxidative stress from excess ROS is also one of the most critical factors in the pathogenesis of cardiovascular and metabolic diseases such as atherosclerosis.
View Article and Find Full Text PDFHigher alkanes are a major class of intermediate volatile organic compounds (IVOCs) emitted by vehicles, which have been considered as important precursors of secondary organic aerosol (SOA) in urban area. Dynamometer experiments were conducted to characterize emissions from gasoline and diesel vehicles in China. Three types of higher alkanes, namely acyclic, cyclic, and bicyclic alkanes, were explicitly quantified through the novel proton transfer reaction time-of-flight mass spectrometer with NO ionization (NO PTR-ToF-MS) with time response of 1 second.
View Article and Find Full Text PDFThe aim of the present study was to investigate the efficacy and safety of anlotinib combined with vinorelbine (NVB) as a second-line treatment for elderly patients with advanced squamous cell lung carcinoma (SqCLC). The present retrospective analysis included 48 elderly patients (aged ≥65 years) diagnosed with advanced SqCLC who received anlotinib in combination with NVB as a second-line therapy between January 2021 and December 2023. The primary endpoints assessed were overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR) and safety profile.
View Article and Find Full Text PDFObjective: This study aims to evaluate the clinical utility and effectiveness of a nomogram model in predicting outcomes for patients with benign esophagogastric anastomotic stenosis (BES) undergoing fluoroscopic balloon dilation (FBD).
Methods: The clinical data of 428 patients with BES who received FBD treatment at our hospital between January 2013 and June 2023 were retrospectively analyzed. The patients were divided into training and validation cohorts in a 7:3 ratio.
Int J Surg Case Rep
January 2025
Introduction And Importance: Calcific tendinitis occurring in the popliteal tendon is extremely rare and has rarely been reported in the past. This case describes a patient who underwent arthroscopic surgery to remove the calcification of the popliteal tendon and achieved satisfactory results after surgery, providing valuable evidence for the feasibility of arthroscopic treatment of calcific tendinitis of the popliteal tendon.
Case Presentation: The patient was a 55-year-old female who was admitted to the hospital due to right knee pain and limited mobility.
Prep Biochem Biotechnol
January 2025
Doramectin, a 16-membered macrocyclic lactone that is widely used in the treatment of mammalian parasitic diseases. Doramectin was produced by mutant using cyclohexanecarboxylic acid as a precursor. As a semi-synthetic insecticidal agent produced, the production of doramectin was low, which could not be satisfy the demands of industrial fermentation.
View Article and Find Full Text PDFTo investigate the influence of cations on the microstructural characteristics of electrochemical reinforcement in soft clay, a study was conducted using three different cationic salt solutions-NaCl, CaCl₂, and FeCl₃-for grouting treatment. Four sets of indoor experiments were performed to examine the reinforcement mechanism of the electrochemical method. The findings indicate that increasing the valence of injected cations significantly affects the electrochemical reinforcement effect and the soil's microstructural properties.
View Article and Find Full Text PDFBackground: Liuweizhiji Gegen-Sangshen oral liquid (LGS), as a Chinese medicinal preparation, is developed from a Traditional Chinese medicinal formula consisting of six Chinese medicinal herbs, including Puerariae lobatae radix, Hoveniae semen, Imperatae rhizoma, Crataegi fructus, Mori fructus and Canarli fructus, and has been extensively utilized in the prevention and treatment of alcoholic liver disease (ALD) clinically. Previous study has demonstrated that LGS dose-dependently mitigated ALD in rat models. However, whether and how the main characteristic constituents of LGS (the flavonoid and polysaccharide fractions, LGSF and LGSP) contribute to the anti-ALD effect remains unclear.
View Article and Find Full Text PDFObjectives: Extensive-stage small cell lung cancer (ES-SCLC) suffering from brain metastases (BM) has a poor prognosis and lacks effective treatment selection. In this study, we explored the efficacy and safety of combination treatment of albumin-bound paclitaxel (nab-ptx), anlotinib, and PD-1/L1 inhibitors for such special population.
Methods: A total of 55 patients diagnosed with ES-SCLC and BM were enrolled in this retrospective study.
Background: Rosavin (RSV) is a naturally occurring compound isolated from Rhodiola species. While RSV has been reported with pharmacological activities of anti-oxidation, anti-inflammation, anti-stress and immunomodulation, its effect on colitis and the underlying mechanisms remain unclear.
Purpose: This study aims to investigate whether and how RSV alleviated colitis in mice.
Objective: We aimed to quantitatively analyze the perfusion characteristics of pancreatic neuroendocrine tumors (pNETs) utilizing dual-source CT imaging.
Methods: Dual-source CT perfusion scans were obtained from patients with pNETs confirmed by surgical or biopsy pathology. Perfusion parameters, including blood flow (BF), blood volume (BV), capillary permeability surface (PS), mean transit time (MTT), contrast transit time to the start (TTS), and contrast transit time to the peak (TTP), were statistically analyzed and compared with nearby healthy tissue.
Effective treatment strategies for second-line therapy in extensive-stage small cell lung cancer (ES-SCLC) are currently lacking. For this reason, we collected and recorded efficacy and safety data from patients with ES-SCLC who had disease progression after first-line treatment and received albumin-bound paclitaxel, anlotinib, and immunotherapy. Preliminary data showed an objective response rate of 37.
View Article and Find Full Text PDFFuture Oncol
November 2024
Prostate cancer (PCa) has become a common disease among middle-aged and elderly men. The lipoxygenase (LOX) pathway plays a crucial role in the occurrence, development, invasion and metastasis of PCa and is therefore considered a new target for the prevention and treatment of PCa. 5-LOX and 12-LOX have a promoting effect on the occurrence, development, invasion and metastasis of PCa.
View Article and Find Full Text PDFDysregulation of SMAD4 (i.e. somatic mutation) is strongly associated with poor pancreatic ductal adenocarcinoma (PDAC) prognosis, yet the molecular mechanisms remain underlying this relationship obscure.
View Article and Find Full Text PDFMed Rev (2021)
October 2024
Cell Commun Signal
October 2024
As the role of RNA modification in gene expression regulation and human diseases, the "epitranscriptome" has been shown to be an important player in regulating many physiological and pathological processes. Meanwhile, the phenomenon of cancer drug resistance is becoming more and more frequent, especially in the case of cancer chemotherapy resistance. In recent years, research on relationship between post-transcriptional modification and cancer including drug resistance has become a hot topic, especially the methylation of the sixth nitrogen site of RNA adenosine-mA (N6-methyladenosine).
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma (HCC) is a malignant tumor characterized by a high mortality rate. The occurrence and progression of HCC are linked to oxidative stress. Glyoxalase-1 (GLO1) plays an important role in regulating oxidative stress, yet the underlying mechanism remains unclear.
View Article and Find Full Text PDFCell Biochem Biophys
September 2024
The integrin α (ITGA) subfamily genes play a fundamental role in various cancers. However, the potential mechanism and application values of ITGA genes in adipogenic differentiation of human adipose-derived stem cells (hADSCs) remain elusive. This study confirmed that ITGA2/3/5 mRNA expressions were repressed during adipogenesis.
View Article and Find Full Text PDFNitrogen oxides (NO) are crucial in tropospheric photochemical ozone (O) production and oxidation capacity. Currently, the widely used NO measurement technique is chemiluminescence (CL) (CL-NO), which tends to overestimate NO due to atmospheric oxidation products of NO (i.e.
View Article and Find Full Text PDFMatching the supply and demand of related ecosystem services can be an effective way to realize long-term sustainable management of the food-energy-water nexus (FEW Nexus) in drylands. However, few studies have focused on the matching of supply and demand for ecosystem services associated with advancing the sustainability of FEW-Nexus, there is limited research in this domain, which lacks systematic and quantitative analysis of the relationship between them and FEW Nexus sustainability. Here, this research takes the West Liaohe River Basin in the arid region of China as a case study.
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