An Anticancer Bioactive Peptide Combined with Oxaliplatin Inhibited Gastric Cancer Cells and .

Background: Gastric cancer has become one of the major diseases threatening human health. This study aimed to investigate the mechanism of an anticancer bioactive peptide (ACBP) combined with oxaliplatin (OXA) on MKN-45, SGC7901, and NCI-N87 differentiated human gastric cancer cells and GES-1 immortalized human gastric mucosal epithelial cells. The therapeutic effect and action mechanism of short-term intermittent ACBP combined with OXA on nude mice with human gastric cancer were also investigated.

A randomized comparison of bencycloquidium bromide, mometasone furoate and a combination for persistent allergic rhinitis.

Background: Moderate to severe persistent allergic rhinitis (AR) poses a substantial socioeconomic burden.

Objectives: We aimed to establish the superiority of bencycloquidium bromide (BCQB) nasal spray and BCQB combined with mometasone furoate nasal spray (MFNS) over MFNS alone in adults with moderate-to-severe persistent AR.

Methods: In this multicentre, randomised controlled clinical trial (NCT05038202), adults with moderate-to-severe persistent AR were randomly assigned to receive the BCQB, MFNS, or a combination treatment, for 4-week periods.

Oxygen adsorption and activation control the photochemical activity of common iron oxyhydroxide polymorphs in mediating oxytetracycline degradation under visible light.

The natural minerals with semiconducting properties possess photochemical activity through generating reactive oxygen species (ROSs) and affect the fate of adsorbed organic pollutants. Iron oxyhydroxides occur in different polymorphic structures under various geological and climatic conditions in natural environment. However, the difference in their photoactivity has not been well understood.

Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease models.

T cells have a remarkable capacity to clonally expand, a process that is intricately linked to their effector activities. As vigorously proliferating T cell also incur substantial DNA lesions, how the dividing T cells safeguard their genomic integrity to allow the generation of T effector cells remains largely unknown. Here we report the identification of the apurinic/apyrimidinic endonuclease-1 (Apex1) as an indispensable molecule for the induction of cytopathic T effectors in mouse models.

Early Lung Adenocarcinoma Manifesting as Irregular Subsolid Nodules: Clinical and CT Characteristics.

Rationale And Objectives: To explore the clinical and computed tomography (CT) characteristics of early-stage lung adenocarcinoma (LADC) that presents with an irregular shape.

Materials And Methods: The CT data of 575 patients with stage IA LADC and 295 with persistent inflammatory lesion (PIL) manifesting as subsolid nodules (SSNs) were analyzed retrospectively. Among these patients, we selected 233 patients with LADC and 140 patients with PIL, who showed irregular SSNs, hereinafter referred to as irregular LADC (I-LADC) and irregular PIL (I-PIL), respectively.

Differential Expression Spectrum of circRNA in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure.

Dilated cardiomyopathy (DCM), a form of non-ischaemic myocardial disease, is characterised by structural and functional cardiac abnormalities. As defined by the World Health Organisation, DCM constitutes a significant cardiac pathology, leading to increased morbidity and mortality due to complications such as heart failure and arrhythmias. The diagnostic process for DCM predominantly employs echocardiography and MRI, with biomarkers like NT-pro BNP and troponin providing supportive, yet non-specific, evidence.

Thyroid-associated ophthalmopathy and ferroptosis: a review of pathological mechanisms and therapeutic strategies.

Thyroid-associated ophthalmopathy (TAO) is an inflammatory orbital disease associated with autoimmune thyroid disorders. Owing to the ambiguous nature of the pathogenesis, contemporary pharmacological treatment strategies predominantly involve the use of glucocorticoids and immunosuppressants. However, the adverse effects associated with these agents in clinical practice necessitate further investigation into the disease's pathogenesis and the identification of novel therapeutic targets and pharmacological interventions.

Human platelet lysate enhances small lipid droplet accumulation of human MSCs through MAPK phosphorylation.

Background: Human platelet lysate (hPL) has emerged as a promising serum substitute to enhance the self-renewal and multipotency of human mesenchymal stem cells (MSCs). Despite its potential, the specific biological mechanisms by which hPL influences MSC phenotypes remain inadequately understood.

Methods: We investigated the biological signaling activated by hPL in two common types of human MSCs: bone marrow-derived MSCs (BMSCs) and adipose-derived MSCs (ASCs).

An Efficient Biosynthetic System for Developing Functional Silk Fibroin-Based Biomaterials.

Long historical evolution and domestication endow silkworms with the super ability to synthesize and secrete massive silk proteins using silk glands. The major component of this secretion consists of silk fibroin, considered a promising biomaterial for tissue repairs and engineering. To further expand the utility of this unique protein, there is a continuing need for silk fibroin functionalization.

Clinical characteristics and early identification of augmented renal clearance in PICU patients with severe sepsis associated with MRSA infection.

Objectives: To investigate the epidemiological characteristics of Augmented Renal Clearance (ARC) in severe sepsis children with MRSA infection and find risk factors to establish a model predicting ARC onset in PICU.

Design: Retrospective study, in which ARC was defined by estimated glomerular filtration rate (eGFR) measured by the modified Schwartz formula above 130 ml/min/1.73 m.

Efficient and Ultralong Room Temperature Phosphorescence from Isolated Molecules under Visible Light Excitation.

Visible-light-excited ultralong organic phosphorescence (UOP) materials hold significant potential for various practical applications. Red-shifted excitation wavelength can be achieved by introducing large π-conjugation structures into organic molecules, thereby increasing intermolecular interactions and coupling. However, generating visible-light-excited UOP from isolated molecules poses a great challenge.

The biological macromolecules constructed Matrigel for cultured organoids in biomedical and tissue engineering.

Matrigel is the most commonly used matrix for 3D organoid cultures. Research on the biomaterial basis of Matrigel for organoid cultures is a highly challenging field. Currently, many studies focus on Matrigel-based biological macromolecules or combinations to construct natural Matrigel and synthetic hydrogel scaffolds based on collagen, peptides, polysaccharides, microbial transglutaminase, DNA supramolecules, and polymers for organoid culture.

Repressor MrERF4 and Activator MrERF34 Synergistically Regulate High Flavonol Accumulation Under UV-B Irradiation in Morella rubra Leaves.

Flavonols are important plant photoprotectants to defence UV-B irradiation, however, the underlying transcriptional regulatory mechanism of rapid flavonol accumulation in response to UV-B remains unknown. In this study, content of flavonols was significantly induced from 0.11 to 3.

Performance and Reaction Mechanism of a Novel Coking Binder Obtained from Low-Grade Coal.

Under the premise of ensuring the quality of coke, reducing coking/fat coal utilization is an urgent problem in the coking industry. This study prepared an extract with softening and bonding characteristics from noncaking low-grade coal by a degradative solvent extraction method. The substitution effect of coking/fat coal by the extract for coking was studied, and the effect mechanism was analyzed in detail.

Transcriptome-based analysis of the molecular mechanism of recombinant protein expression in Periplaneta americana cells.

The Insect Cell-Baculovirus Expression Vector System (IC-BEVS) is widely used for the generation of a variety of gene products, including proteins, vaccines, and gene therapy vectors; however, it has some limitations, including a constrained host range and low protein yields. In a previous study, we established the RIRI-PA1 cell line, which was derived from Periplaneta americana. This cell line is susceptible to Autographa californica multiple nucleopolyhedrovirus (AcMNPV) infection, which results in a higher yield production of recombinant protein within a short post-infection period of 24-48 h compared to the commonly used engineered cell line Sf21.

Efficacy of integrated traditional Chinese and western medicine in managing mild-moderate acute pancreatitis: a real-world clinical perspective analysis.

Background: Given the prevalent utilization of integrated traditional Chinese and western medicine (ITCWM) in the management of acute pancreatitis, the majority of studies have concentrated on severe cases, lacking robust evidence-based medical research. Real-world investigations can provide an objective assessment of the clinical effectiveness of combining traditional Chinese medicine with western medicine. Consequently, relying on real-world research, we intend to evaluate the clinical efficacy and safety of the combined approach in treating mild to moderate acute pancreatitis.

Gastrodin ameliorates diabetic nephropathy by activating the AMPK/Nrf2 pathway.

Diabetic nephropathy (DN) is a leading cause of end-stage kidney failure, contributing to elevated morbidity and mortality rates in individuals with diabetes. Despite its potential renoprotective effects, the molecular mechanism by which gastrodin (GSTD) impacts DN remains unclear. To investigate this, mice were initially induced with DN via intraperitoneal streptozotocin (STZ) injection (50 mg/kg) and subsequently treated with varying doses of GSTD (5, 10, 20 mg/kg).

Cu-mediated telomeric dimeric G-quadruplex DNAzyme for highly sensitive colorimetric detection of deferasirox.

Deferasirox (DEF) is an important iron chelator for treatment of iron overload-related diseases. Monitoring DEF concentration in human serum will provide some valuable information for clinical diagnosis and therapy of such diseases. In this study, we developed a peroxidase-mimicking colorimetric sensor for the detection of DEF by simple assembly of a telomeric dimeric G-quadruplex DNAzyme with Cu.

Persistent chemiluminescence-based nanosensor for portable point-of-care testing of HO.

A novel glow-type chemiluminescence (CL)-based nanosensing system was developed for sensitive and rapid point-of-care testing (POCT) of HO in food. CuSe nanoparticles (CuSe) have excellent peroxidase-like activity. After being modified with thiols of 4-mercaptophenylboronic acid (MBA) (CuSe@MBA), luminol can be catalyzed to produce long-lasting CL in the presence of HO.

Experimental Investigation on the Performance of SBS-Modified Asphalt Waterproofing Membrane by Thermo-Oxidative Aging and Freeze-Thaw Cycle.

With global warming in recent years, extreme weather conditions have increased in frequency and intensity, exacerbating the challenges for waterproofing materials. The current stages of SBS asphalt waterproofing membrane aging research mainly focus on the raw materials and modifiers in a single factor; multifactor-coupled aging research is less studied. This study focused on the coupled aging characteristics of SBS-modified asphalt waterproofing membranes, aiming to reveal the mechanism of its influence on the material's performance under the environmental effects of high temperature and freeze-thaw.