Publications by authors named "Li Xia Hu"
The aim of this study was to conduct experiments using laser speckle contrast imaging (LSCI) technology to investigate the effects of high salt diet on renal vascular reactivity in mice. LSCI is a technology for monitoring blood flow based on the laser speckle principle. It has been widely used to detect microcirculatory functions in tissues such as the skin and brain.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create a standardized white light gastroscopy (WLG) procedure for screening gastric issues, including early gastric cancer, in China, and evaluate its clinical effectiveness.
- A total of 3,207 patients underwent both conventional and standardized WLG procedures across multiple hospitals, revealing that the standardized approach took longer but resulted in a higher detection rate of gastric lesions (52.5% vs 38.4%).
- Participants and endoscopists reported greater satisfaction with the standardized procedure, indicating it is a more effective and feasible option for clinical practice despite the increased time required.
Article Synopsis
- - This study explores the antioxidant properties of Inula nervosa Wall flowers (BINW) using various standard assays, including DPPH, ABTS, and FRAP methodologies.
- - Researchers identified 46 chemical compounds and highlighted nine prominent ones through advanced techniques like UHPLC-QTOF-MS and photodiode array detection, as well as statistical analyses like PCA.
- - The findings suggest that BINW from Yunnan has superior antioxidant abilities compared to those from other regions, contributing to a better understanding of its traditional medicinal quality and establishing standards for different BINW sources.
Article Synopsis
- The study aimed to evaluate the effects of medicated thread moxibustion, a traditional Zhuang Minority medical practice, on the Th17/IL-17F signaling pathway in rats with ulcerative colitis (UC) to understand its beneficial mechanisms.
- Forty male rats were divided into four groups: normal control, model, medication (treated with salazosulfapyridine), and medicated thread moxibustion (MTM), observing various health indicators after UC was induced.
- Results showed increased levels of Th17 cells and IL-17F in the UC model group, but these levels decreased after treatment in both the medication and MTM groups, indicating effective intervention with no significant differences between the two treatment methods.
Article Synopsis
- A previous study identified that tumor-specific hepatic stellate cells (tHSCs) enhance the expression of dendritic cell-derived immunoglobulin receptor 2 (DIgR2) in bone marrow-derived dendritic cells (mDCs), which inhibits T cell activation in the spleen.
- The current research investigates how tHSCs stimulate DIgR2 expression through Nrf2 signaling, showing that co-culture with tHSCs activates Nrf2 in mDCs, leading to increased expression of Nrf2-dependent genes and DIgR2.
- Additionally, it was found that reactive oxygen species (ROS) production plays a role in this process, as blocking ROS inhibited Nrf2 activation and
Article Synopsis
- The study evaluates the safety of a new contraceptive device, the nano-Cu/LDPE IUD, by testing its toxicity in mice and rats through acute and subchronic administration.
- Acute toxicity tests showed no significant adverse effects or changes in body weight, while the 13-week subchronic study also indicated no signs of toxicity or mortality in either the treatment or control groups.
- Histological examinations confirmed that the inserted nano-Cu/LDPE material did not cause harmful changes in organ structure, suggesting the device is safe for use.
Article Synopsis
- Tumor-specific hepatic stellate cells (tHSCs) play a role in the progression of hepatocellular carcinoma (HCC) by influencing dendritic cells (DCs).
- Co-culture with tHSCs increases DIgR2 expression in bone marrow-derived DCs, which depends on the activation of the MEK-ERK signaling pathway.
- tHSCs also reduce cytokine production and induce T-cell hypo-responsiveness, leading to decreased activity of cytotoxic T lymphocytes, effects that can be reversed by silencing DIgR2 in DCs.
Article Synopsis
- Tumor-specific hepatic stellate cells (tHSCs) play a supportive role in the development and progression of hepatocellular carcinoma (HCC).
- Previous research indicated that tHSCs promote the expression of DIgR2, a receptor that hinders immune responses initiated by dendritic cells (DCs).
- The new study found that silencing DIgR2 with siRNA significantly reduced HCC growth in rats and enhanced the effectiveness of the chemotherapy drug 5-FU, while also increasing the activity of tumor-derived DCs (tDCs) by boosting their expression of key immune activation markers.
Article Synopsis
- The study investigated how different emulsifier systems (APG, Span-Tween, A6/25) impact the transdermal absorption of several Chinese herbal compounds (baicalin, matrine, glycyrrhetinic acid, and emodin) using excised mice skin and Franz diffusion cells.
- Results showed that matrine had the highest cumulative permeation amount, followed by baicalin, glycyrrhetinic acid, and emodin.
- Additionally, the Span-Tween emulsifier system consistently yielded better cumulative permeation amounts and rates compared to other emulsifiers, but there was no clear pattern in how different emulsifier systems affected the absorption of the same herbal ingredients.
Article Synopsis
- Researchers developed a nanocomposite material made of copper and low-density polyethylene (nano-Cu/LDPE) for possible use in intrauterine devices (IUDs).
- The study evaluated how this material affects certain proteins (PAI-1, SP, and SP-R) in the uterine lining of different animal models over time, and compared its effects to those of bulk copper and LDPE.
- Findings showed that nano-Cu/LDPE caused less damage to the endometrium compared to bulk copper, suggesting it could be a safer alternative for future IUD materials.
Article Synopsis
- The article discusses the evaluation of a new copper/low-density polyethylene nanocomposite intrauterine device (nano-Cu/LDPE IUD) for its biocompatibility and safety for clinical use.
- Various tests were conducted, including cytotoxicity assays on L929 mouse fibroblasts and irritation tests on rabbits and guinea pigs, which showed the material to be non-toxic or mildly cytotoxic.
- Results indicate that the nano-Cu/LDPE IUD has good biocompatibility with no significant irritation or sensitization observed, suggesting it is suitable for future clinical applications as a contraceptive device.
Synergistic effects of exemestane and aspirin on MCF-7 human breast cancer cells.
Asian Pac J Cancer Prev
July 2013
Article Synopsis
- * Using methods like the MTT assay and flow cytometry, results showed that the drug combination significantly reduced cell viability and caused a synergistic effect on cell proliferation.
- * The findings suggest that using exemestane and aspirin together could be a promising treatment strategy for hormone-dependent breast cancer, outperforming each drug used individually.
Article Synopsis
- Recent studies on IL-8 polymorphism and its link to colorectal cancer have shown mixed results, prompting a thorough meta-analysis to evaluate the relationship.
- The meta-analysis included nine case-control studies with a total of 7,003 individuals but found no significant associations between IL-8 polymorphism and colorectal cancer risk across various genetic models.
- The conclusion indicates that the IL-8-251T>A polymorphism does not appear to influence colorectal cancer susceptibility, but further research is needed due to the limitations of the analysis.