Dental caries and associated factors among Chinese children and adolescents: A protocol for systematic review and meta-analysis.

Background: Dental caries is a common disease under the action of many factors. Dental caries may occur in all age groups, among which children and adolescents are at high risk of dental caries. Early identification of the risk factors of dental caries is very important for clinical staff to prevent and intervene as soon as possible and reduce the incidence of dental caries.

Oral administration co-delivery nanoparticles of docetaxel and bevacizumab for improving intestinal absorption and enhancing anticancer activity.

In this study, to improve the intestinal absorption of small molecule chemotherapeutic drug docetaxel (DTX) and macromolecular monoclonal antibody drug bevacizumab (BVZ), we designed and prepared a type of co-delivery nanoparticles for the oral administration of DTX and BVZ. Carboxymethyl chitosan (CMC) and poly(lactic-co-glycolic acid) (PLGA) were used as the carrier of DTX nanoparticles (CPNP), and methoxy polyethylene glycol-poly (β-amino ester) (mPEG-PAE) was used as the carrier of BVZ nanoparticles (PPNP). Then, the two nanoparticles were physically mixed in mass ratios to form mixed co-delivery nanoparticles, which was named as CPNP&PPNP.

Enhanced photothermal signal detection by graphene oxide integrated long period fiber grating for on-site quantification of sodium copper chlorophyllin.

An enhanced photothermal signal detection method based on graphene oxide (GO) integrated long period fiber grating (LPFG) for on-site sodium copper chlorophyllin (SCC) quantification is proposed. SCC, as a porphyrin compound, can be photonically excited to induce a stronger photothermal effect. GO offers superior molecular adsorption and thermal conductivity properties; depositing it on the LPFG surface significantly improves the sensitivity and detection efficiency of the SCC photothermal signal, when irradiated with a 405 nm laser.

Validation of the Hedonic and Eudaimonic Motives for Activities-Revised Scale in Chinese Adults.

The Hedonic and Eudaimonic Motives for Activities-Revised scale (HEMA-R) is one of the most extensively used instruments to assess how people pursue well-being. The main aims of the present research were to translate HEMA-R into Chinese and test its construct and predictive validity as well as measurement invariance across gender. In Study 1, we conducted confirmatory factor analysis with data containing 1090 Chinese undergraduates, and replicated the two-factor model which has been found in other studies.

Associations of spicy food flavour and intake frequency with blood lipid levels and risk of abnormal serum lipid levels in Chinese rural population: a cross-sectional study.

Objective: The purpose of the current study was to investigate associations between spicy food intake and serum lipids levels in Chinese rural population.

Design: Information on spicy food flavour and intake frequency was obtained using a two-item questionnaire survey. Dietary data were collected using a validated thirteen-item FFQ.

Genome-wide analysis of SET-domain group histone methyltransferases in apple reveals their role in development and stress responses.

Background: Histone lysine methylation plays an important role in plant development and stress responses by activating or repressing gene expression. Histone lysine methylation is catalyzed by a class of SET-domain group proteins (SDGs). Although an increasing number of studies have shown that SDGs play important regulatory roles in development and stress responses, the functions of SDGs in apple remain unclear.

miR-6858 plays a key role in the process of melatonin inhibition of the malignant biological behavior of glioma.

MicroRNAs (miRNAs), small non-coding RNA molecules with a length of 18-25 nucleotides, have been shown to be involved in mediating various malignant properties of GBM, including growth, invasion and angiogenesis. Here, we investigated whether miRNAs might be involved in mediating the suppression of malignant properties of GBM by melatonin (MEL), an amine hormone secreted by the pineal gland. Sequencing was performed to screen specifically for miRNAs induced by MEL in U87 and an orthotopically xenografted primary GBM cell line, GBM#P3.

Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.

Objective: Parkinson's disease (PD) is a degenerative disorder characterized by steady motor function loss. PD pathogenesis remains inconclusive, but aberrant immune responses might play important roles. We hypothesized that imbalance between T helper (Th) 1 and regulatory T (Treg) cells was essential in experimental PD.

Exceptional Mechanical Properties and Heat Resistance of Photocurable Bismaleimide Ink for 3D Printing.

Photosensitive resins used in three-dimensional (3D) printing are characterized by high forming precision and fast processing speed; however, they often possess poor mechanical properties and heat resistance. In this study, we report a photocurable bismaleimide ink with excellent comprehensive performance for stereolithography (SLA) 3D printing. First, the main chain of bismaleimide with an amino group (BDM) was synthesized, and then, the glycidyl methacrylate was grafted to the amino group to obtain the bismaleimide oligomer with an unsaturated double bond.

α Promoter Methylation May Modify the Association Between Lipid Metabolism and Type 2 Diabetes in Chinese Farmers.

This study is aimed to explore the potential association among the estrogen receptor alpha (α) promoter methylation, lipid metabolism and the risk of type 2 diabetes mellitus (T2DM). A total of 1143 rural residents were recruited randomly from Henan Province, China. The circulating methylation levels in α promoter region were determined by quantitative methylation-specific polymerase chain reaction.

Long-term exposure to PM and PM is associated with serum cortisone level and meat intake plays a moderation role.

Background: Although short-term exposure to particulate matter (PM) was associated with increased glucocorticoids (GCs) levels, available evidence on associations of long-term exposure to PM and GCs levels is still scant. Previous studies has showed that meat intake is associated with sex hormones levels, but it is unknown whether meat intake is associated with GCs levels. Furthermore, the role of meat intake in the associations between PM and GCs levels remains unclear.

Four-channel toroidal crystal x-ray imager for laser-produced plasmas.

The motion law of complex fluids under extreme conditions is an important aspect of high energy density physics research. It has been demonstrated that using multi-channel curved crystals and a framing camera to observe the laser-produced target pellets doped with tracer elements is an appropriate method for investigating this law. This paper presents a feasible design scheme for a multi-channel toroidal imager, with the ray trace model used to verify the rationality of the evaluation method and the aberration of single toroidal crystal imaging.

Effects of Apoptin-Induced Endoplasmic Reticulum Stress on Lipid Metabolism, Migration, and Invasion of HepG-2 Cells.

In this study, we investigated the effects of Apoptin-induced endoplasmic reticulum (ER) stress on lipid metabolism, migration and invasion of HepG-2 cells, and preliminarily explored the relationship between endoplasmic reticulum stress, lipid metabolism, migration, and invasion. The effects of Apoptin on ER function and structure in HepG-2 cells were determined by flow cytometry, fluorescence staining and western blotting by assessing the expression levels of ER stress related proteins. The effects of Apoptin on HepG-2 cells' lipid metabolism were determined by western blot analysis of the expression levels of triglyceride, cholesterol, and lipid metabolism related enzymes.

Effects of Apigenin Treatment on Random Skin Flap Survival in Rats.

Random skin flaps are often used in plastic surgery, but the complications of marginal flap ischemia and necrosis often limit their wider clinical application. Apigenin (Api) is a flavonoid found in various fruits and vegetables. Api has been shown to promote angiogenesis, as well as reduce oxidative stress, membrane damage, and inflammation.

Strategy of Dimercaptothiol as Self-assembled Monolayers Enhance the Sensitivity of SPR Immunosensor for Detection of Salbutamol.

The formation of self-assembled monolayers (SAMs) is a normal method for the immobilization of biorecognition elements immobilized on SPR sensors. With this method, mercaptopropionic acid (MPA) with carboxylic and thiol group is the most commonly used. Dimercaptosuccinic acid (DMSA) having two carboxylics and two thiol groups is a classical antidote for heavy metal ions.

Semaphorin 3A contributes to sepsis‑induced immunosuppression by impairing CD4 T cell anergy.

Semaphorin 3A (Sema3A), a member of the Sema family of proteins, appears to serve an important role in sepsis and sepsis‑induced immunosuppression and has been regarded as a crucial regulator involved in cellular immune response. However, the role of Sema3A in CD4 T cell anergy during sepsis remains to be elucidated. In the present study, the cecal ligation and perforation model and lipopolysaccharide (LPS) were used to simulate sepsis and the role of Sema3A in sepsis‑induced CD4 T cell anergy was investigated and .

Quantification of crustacean tropomyosin in foods using high-performance liquid chromatography-tandem mass spectrometry method.

Background: Allergic reactions to crustacean products have been increasing owing to the rising consumption. Tropomyosin (TM) is the main crustacean allergen; it has a coiled-coil structure, which shows stability to various food processing methods. Crustacean processed products have been used in several food products, thereby causing greater difficulties in detecting TM in these products.

Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway.

Background And Aim: Furin is a proprotein convertase reported to have protective effects in several autoimmune diseases. However, the role of furin in ulcerative colitis (UC) remains unclear. We aimed to clarify this role.

Generation of active Co(III) and peroxodiphosphate by synergistic electrocatalytic system with phosphate and the mediator cobalt(II) and its degradation performance.

The promising synergistic electrocatalytic system of phosphate (PO) with the mediator cobalt(II) (for short E-Co(II)-PO) was employed to degrade cationic dye methylene blue (MB). The exploration in the electrocatalytic process revealed that the main intermediate active oxidation products were Co(III), accompanied with hydroxyl radicals and peroxodiphosphates (PO). Their synergistic electrocatalytic degradation rate to MB and total organic carbon (TOC) was up to 100 and 60% in 40 min, respectively, which was 5 times and 2.

Influencing Factors of Psychological Well-Being of the Non-designated Hospital Staff in China During the COVID-19 Pandemic.

Recent studies report that hospital staff at the forefront of caring for COVID-19 patients experience increased psychological distress. To effectively manage the outbreak of COVID-19, China established COVID-19 designated and non-designated hospitals. To date, few studies have examined the impacts of COVID-19 on psychological health of staff working at non-designated hospitals.

Regulating Lithium Electrodeposition with Laser-Structured Current Collectors for Stable Lithium Metal Batteries.

Lithium-metal batteries (LMBs) are promising electrochemical energy storage devices with high energy densities. However, the extreme reactivity of metallic lithium, the large volumetric change of the electrode during cycling, and the notorious dendrite formation issues lead to low cyclic stability and safety concerns, hindering the practical application of LMBs. In particular, the intrinsic tendency of uneven lithium deposition and the large internal electrode stress lead to the piecing of solid electrolyte interphases (SEIs), thereby resulting in fast decay of the anode.

The mediation role of SOCS3 methylation in the effect of serum testosterone on type 2 diabetes.

Background: Previous studies reported that testosterone and DNA methylation of suppressor of cytokine signaling-3 (SOCS3) were associated with type 2 diabetes (T2D). Testosterone affects SOCS3 gene expression. Therefore, we aimed to investigate how the SOCS3 methylation mediates the relationship between testosterone and T2D among Chinese rural adults.

Identification of a prognostic and therapeutic immune signature associated with hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is one of the most prevalent and inflammation-associated cancers. The tumor microenvironment (TME) plays an essential role in HCC development and metastasis, leading to poor prognosis. The overall TME immune cells infiltration characterizations mediated by immune-related genes (IRGs) remain unclear.

Colonization characteristics of bacterial communities on plastic debris: The localization of immigrant bacterial communities.

The unique characteristics of bacterial communities on plastic debris and microplastics in the environment have been widely studied in recent years. However, due to the randomness of sampling, it is hard to identify whether the unique characteristics of bacterial communities on plastic debris is due to the plastics as substrate itself, or the accumulation and transportation by plastics. Therefore, the ecological effects of bacterial communities on plastic debris, including the species invasion, are still not clear.